Protein Alignment Sirt1 and Sirt3

DIOPT Version :9

• Sequence 1: NP_477351.1
• Gene: Sirt1 / 34708
• FlyBaseID: FBgn0024291
• Length: 823
• Species: Drosophila melanogaster
• Sequence 2: NP_001171275.1
• Gene: Sirt3 / 64384
• MGIID: 1927665
• Length: 334
• Species: Mus musculus
• Alignment Length: 269
• Identity: 105/269 - (39%)
• Similarity: 160/269 - (59%)
• Gaps: 37/269 - (13%)

  Fly   210 TFDDVISLV--KKSQKIIVLTGAGVSVSCGIPDFRST-NGIYARLAHDFPDLPDPQAMFDINYFK 271
            :..||..|:  :...:::|:.|||:|...|||||||. :|:|:.|..  .|:|.|:|:|::.:|.
Mouse    59 SLQDVAELLRTRACSRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQ--YDIPYPEAIFELGFFF 121

  Fly   272 RDPRPFYKFAREIYPGEFQPSPCHRFIKMLETKGKLLRNYTQNIDTLERVAGI--QRVIECHGSF 334
            .:|:||:..|:|:|||.::|:..|.|:::|..|..|||.||||||.|||.:||  .:::|.||:|
Mouse   122 HNPKPFFMLAKELYPGHYRPNVTHYFLRLLHDKELLLRLYTQNIDGLERASGIPASKLVEAHGTF 186

  Fly   335 STASCTKCRFKCNADALRADIFAQRIPVCPQCQPNKEQSVDASVAVTEEELRQLVENGIMKPDIV 399
            .||:||.||.....:.:.||:.|.|:|.||.|                        .|::|||||
Mouse   187 VTATCTVCRRSFPGEDIWADVMADRVPRCPVC------------------------TGVVKPDIV 227

  Fly   400 FFGEGLPDEYHTVMATDKDVCDLLIVIGSSLKVRPVAHIPSSIPATVPQILINRE-----QLHHL 459
            ||||.||..:...|| |..:.|||:::|:||:|.|.|.:..::..:||::||||:     .|...
Mouse   228 FFGEQLPARFLLHMA-DFALADLLLILGTSLEVEPFASLSEAVQKSVPRLLINRDLVGPFVLSPR 291

  Fly   460 KFDVELLGD 468
            :.||..|||
Mouse   292 RKDVVQLGD 300

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt1	NP_477351.1	DUF592	<202..228	CDD:282439	4/19 (21%)
		SIRT1	222..476	CDD:238699	102/255 (40%)
Sirt3	NP_001171275.1	SIRT1	74..308	CDD:238699	102/254 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0846
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D512963at33208
OrthoFinder	1	1.000	-	-		FOG0000643
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R577
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850