DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sirt1 and Sirt2

DIOPT Version :9

Sequence 1:NP_477351.1 Gene:Sirt1 / 34708 FlyBaseID:FBgn0024291 Length:823 Species:Drosophila melanogaster
Sequence 2:NP_071877.3 Gene:Sirt2 / 64383 MGIID:1927664 Length:389 Species:Mus musculus


Alignment Length:500 Identity:155/500 - (31%)
Similarity:226/500 - (45%) Gaps:145/500 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   117 EEEEEDDEEGITGTSNEDEDSSSNCSSSVEPDWKLRWLQREFYTGRVPRQVIASIMPHFATGLAG 181
            |.:..|..|...|...|.:||.|:....                               |||  |
Mouse     3 EPDPSDPLETQAGKVQEAQDSDSDTEGG-------------------------------ATG--G 34

  Fly   182 DTDDSVLWDYLAHLLNEPKRRNKLASVNTFDDVISLV--KKSQKIIVLTGAGVSVSCGIPDFRS- 243
            :.:...|.:.....|....::.:|....|.:.|...:  ::.:|:|.|.|||:|.|.||||||| 
Mouse    35 EAEMDFLRNLFTQTLGLGSQKERLLDELTLEGVTRYMQSERCRKVICLVGAGISTSAGIPDFRSP 99

  Fly   244 TNGIYARLA--HDFPDLPDPQAMFDINYFKRDPRPFYKFAREIYPGEFQPSPCHRFIKMLETKGK 306
            :.|:||.|.  |    ||.|:|:|:|:|||:.|.||:..|:|:|||:|:|:.||.||::|:.||.
Mouse   100 STGLYANLEKYH----LPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFIRLLKEKGL 160

  Fly   307 LLRNYTQNIDTLERVAGI--QRVIECHGSFSTASC--TKCRFKCNADALRADIFAQRIPVCPQCQ 367
            |||.|||||||||||||:  |.::|.||:|.|:.|  |.||.:.....::..||::..|.|.|||
Mouse   161 LLRCYTQNIDTLERVAGLEPQDLVEAHGTFYTSHCVNTSCRKEYTMGWMKEKIFSEATPRCEQCQ 225

  Fly   368 PNKEQSVDASVAVTEEELRQLVENGIMKPDIVFFGEGLPDEYHTVMATDKDVCDLLIVIGSSLKV 432
                                    .::|||||||||.||..:.:.|.:|....||||::|:||:|
Mouse   226 ------------------------SVVKPDIVFFGENLPSRFFSCMQSDFSKVDLLIIMGTSLQV 266

  Fly   433 RPVAHIPSSIPATVPQILINREQLHH--------------LKF-------DVELLGDSDVIINQI 476
            :|.|.:.|..|...|::|||:|:...              :.|       ||..|||.|    |.
Mouse   267 QPFASLISKAPLATPRLLINKEKTGQTDPFLGMMMGLGGGMDFDSKKAYRDVAWLGDCD----QG 327

  Fly   477 CHRLSDNDDCWRQLCCDESVLTESKELMPPEHSNHHLHHHLLHHRHCSSESERQSQLDTDTQSIK 541
            |..|:|... |::         |.::|:..||:|                      :|..:.|..
Mouse   328 CLALADLLG-WKK---------ELEDLVRREHAN----------------------IDAQSGSQA 360

  Fly   542 SNSSADYILGSAGTCSDSGFESSTFSCGKRSTAAEAAAIERIKTD 586
            .|                  .|:|.|.||....|:.||..:.|.:
Mouse   361 PN------------------PSTTISPGKSPPPAKEAARTKEKEE 387

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sirt1NP_477351.1 DUF592 <202..228 CDD:282439 5/27 (19%)
SIRT1 222..476 CDD:238699 116/281 (41%)
Sirt2NP_071877.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..34 11/63 (17%)
Nuclear export signal. /evidence=ECO:0000250 41..51 2/9 (22%)
SIRT1 77..331 CDD:238699 118/285 (41%)
Peptide inhibitor binding. /evidence=ECO:0000250 116..120 1/3 (33%)
Peptide inhibitor binding. /evidence=ECO:0000250 232..301 27/68 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 350..389 13/77 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0846
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000643
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.810

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