DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sirt1 and SIRT6

DIOPT Version :9

Sequence 1:	NP_477351.1	Gene:	Sirt1 / 34708	FlyBaseID:	FBgn0024291	Length:	823	Species:	Drosophila melanogaster
Sequence 2:	NP_057623.2	Gene:	SIRT6 / 51548	HGNCID:	14934	Length:	355	Species:	Homo sapiens

Alignment Length:	336	Identity:	76/336 - (22%)
Similarity:	132/336 - (39%)	Gaps:	83/336 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 ASIMPHFATGLAGDTDDSVLWDYLAHLLNEPKRRNKLASVNTFDDVISLVKKSQKIIVLTGAGVS 233
            |.:.|:...|..|          |..:.:.|:...:...     ::..||.:|..::..||||:|
Human     7 AGLSPYADKGKCG----------LPEIFDPPEELERKVW-----ELARLVWQSSSVVFHTGAGIS 56

  Fly   234 VSCGIPDFRSTNGIYAR----LAHDFPDLPDPQAMFDINYFKRDPRPFYKFAREIYPGEFQPSPC 294
            .:.||||||..:|::..    ||        |:  ||..         ::.||        |:..
Human    57 TASGIPDFRGPHGVWTMEERGLA--------PK--FDTT---------FESAR--------PTQT 94

  Fly   295 HRFIKMLETKGKLLRNYTQNIDTLERVAGIQR--VIECHGSFSTASCTKCRFKCNAD------AL 351
            |..:..||..|.|....:||:|.|...:|..|  :.|.||:.....|.||:.:...|      .|
Human    95 HMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGL 159

  Fly   352 RADIFAQRIPVCPQCQPNKEQSVDASVAVTEEELRQLVENGIMKPDIVFFGEGLPDEYHTVMATD 416
            :|   ..|:     |...|.:.:.|.             .|.::..|:.:.:.|||....:....
Human   160 KA---TGRL-----CTVAKARGLRAC-------------RGELRDTILDWEDSLPDRDLALADEA 203

  Fly   417 KDVCDLLIVIGSSLKVRPVAHIPSSIPATVPQ----ILINREQLHHLKF-DVELLGDSDVIINQI 476
            ....||.|.:|:||::||..::|.   ||..:    :::|.:...|.:. |:.:.|..|.::.::
Human   204 SRNADLSITLGTSLQIRPSGNLPL---ATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRL 265

  Fly   477 CHRLSDNDDCW 487
            ...|......|
Human   266 MKHLGLEIPAW 276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sirt1	NP_477351.1	DUF592	<202..228	CDD:282439	3/25 (12%)
Sirt1	NP_477351.1	SIRT1	222..476	CDD:238699	65/270 (24%)
SIRT6	NP_057623.2	SIRT7	45..257	CDD:238701	63/262 (24%)
SIRT6	NP_057623.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	284..355
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0846
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810