Protein Alignment Sirt1 and SIRT6

DIOPT Version :10

• Sequence 1: NP_477351.1
• Gene: Sirt1 / 34708
• FlyBaseID: FBgn0024291
• Length: 823
• Species: Drosophila melanogaster
• Sequence 2: NP_057623.2
• Gene: SIRT6 / 51548
• HGNCID: 14934
• Length: 355
• Species: Homo sapiens
• Alignment Length: 109
• Identity: 23/109 - (21%)
• Similarity: 33/109 - (30%)
• Gaps: 50/109 - (45%)

  Fly    31 DVLLAYLCSRPGTTLS--IKD--ISQEMAIN--------------SYDIV-------STLQALGM 70
            |:.||.|....|....  .:|  |.||:.::              ::|:|       .||..||.
Human   101 DIRLAKLYGADGLVFGALTEDGHIDQELCLSLVALCRPLPVTFHRAFDMVQDPMAALETLLTLGF 165

  Fly    71 MKYWKGKHIILKKLDVLDEYEERVKRRGNMPKIDQSCLKWTPFV 114
                                 |||...|    .|.|.|:..|.:
Human   166 ---------------------ERVLTSG----CDSSALEGLPLI 184

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt1	NP_477351.1	SIRT1	222..476	CDD:238699
SIRT6	NP_057623.2	SIRT7	45..257	CDD:238701	23/109 (21%)
		Disordered. /evidence=ECO:0000269|PubMed:33067423	284..355