Protein Alignment Sirt1 and SIRT7

DIOPT Version :9

• Sequence 1: NP_477351.1
• Gene: Sirt1 / 34708
• FlyBaseID: FBgn0024291
• Length: 823
• Species: Drosophila melanogaster
• Sequence 2: XP_024306560.1
• Gene: SIRT7 / 51547
• HGNCID: 14935
• Length: 442
• Species: Homo sapiens
• Alignment Length: 291
• Identity: 71/291 - (24%)
• Similarity: 105/291 - (36%)
• Gaps: 93/291 - (31%)

  Fly   190 DYLAHLLNEPKRRN--KLASVNTFDD----------VISLVKKSQKIIVLTGAGVSVSCGIPDFR 242
            |.:..|....:||.  |.......||          :.|.|:.::.::|.||||:|.:..|||:|
Human    56 DLVTELQGRSRRREGLKRRQEEVCDDPEELRGKVRELASAVRNAKYLVVYTGAGISTAASIPDYR 120

  Fly   243 STNGIYARL----AHDFPDLPDPQAMFDINYFKRDPRPFYKFAREIYPGEFQPSPCHRFIKMLET 303
            ..||::..|    :....||                            .|.:|:..|..|..|..
Human   121 GPNGVWTLLQKGRSVSAADL----------------------------SEAEPTLTHMSITRLHE 157

  Fly   304 KGKLLRNYTQNIDTLERVAGIQR--VIECHGSFSTASCTKCRFKCNADALRADIFAQRIPVCPQC 366
            :..:....:||.|.|...:|:.|  :.|.||:                        ..|.||..|
Human   158 QKLVQHVVSQNCDGLHLRSGLPRTAISELHGN------------------------MYIEVCTSC 198

  Fly   367 QPNKE--QSVDASVAVTEEELRQLVENG--------IMKPDIVFFGE----GLPDEYHTVMATD- 416
            .||:|  :..|    |||.......:.|        .::..||.|||    |.|..:..  ||:
Human   199 VPNREYVRVFD----VTERTALHRHQTGRTCHKCGTQLRDTIVHFGERGTLGQPLNWEA--ATEA 257

  Fly   417 KDVCDLLIVIGSSLKVRPVAHIPSSIPATVP 447
            ....|.::.:|||||||  |....|.|:..|
Human   258 ASRADTILCLGSSLKVR--ADDTMSEPSPCP 286

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt1	NP_477351.1	DUF592	<202..228	CDD:282439	7/37 (19%)
		SIRT1	222..476	CDD:238699	62/247 (25%)
SIRT7	XP_024306560.1	YscO	16..>101	CDD:284686	9/44 (20%)
		SIRT7	100..356	CDD:238701	62/247 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0846
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810