Protein Alignment Sirt1 and Sirt2

DIOPT Version :9

• Sequence 1: NP_477351.1
• Gene: Sirt1 / 34708
• FlyBaseID: FBgn0024291
• Length: 823
• Species: Drosophila melanogaster
• Sequence 2: NP_001287422.2
• Gene: Sirt2 / 42414
• FlyBaseID: FBgn0038788
• Length: 386
• Species: Drosophila melanogaster
• Alignment Length: 506
• Identity: 148/506 - (29%)
• Similarity: 221/506 - (43%)
• Gaps: 154/506 - (30%)

  Fly    72 GEIKTKTLAAREEQEIGANLEHKTKNPTKSMGEDEDDEEEEEEDDEEEEEDDEEGITGTSNEDED 136
            |:|:.|    :|||            ||........|::||..||..::
  Fly     2 GDIEVK----KEEQ------------PTTPSNSSSSDDDEEAPDDTMDK---------------- 34

  Fly   137 SSSNCSSSVEPDWKLRWLQREFYTGRVPRQVIASIMPHFATGLAGDTDDSVLWDYLAHLLNEPKR 201
                              .|.|:...:          |    |.|.:|           ..|..:
  Fly    35 ------------------VRRFFANTL----------H----LGGSSD-----------AKEEVK 56

  Fly   202 RNKLASVNTFDDVIS--LVKKSQKIIVLTGAGVSVSCGIPDFRST-NGIYARLAHDFPDLPDPQA 263
            ..|:....:||....  .|...:||:.:.|||:|.|.|||||||. :|:|:.|..  .:||.|.|
  Fly    57 VEKVIPDLSFDGFAEHWRVHGFRKIVTMVGAGISTSAGIPDFRSPGSGLYSNLKK--YELPHPTA 119

  Fly   264 MFDINYFKRDPRPFYKFAREIYPGEFQPSPCHRFIKMLETKGKLLRNYTQNIDTLERVAGI--QR 326
            :||::||:::|.||:..|:|:|||.|.|:|.|.||::|..||.|.|:||||||||:|:.|:  .:
  Fly   120 IFDLDYFEKNPAPFFALAKELYPGSFIPTPAHYFIRLLNDKGLLQRHYTQNIDTLDRLTGLPEDK 184

  Fly   327 VIECHGSFSTASCTKCRFKCNADALRADIFAQRIPVCPQCQPNKEQSVDASVAVTEEELRQLVEN 391
            :||.||||.|..|.|||.:.:.|.::|:|||.|:|.|.:||
  Fly   185 IIEAHGSFHTNHCIKCRKEYDMDWMKAEIFADRLPKCQKCQ------------------------ 225

  Fly   392 GIMKPDIVFFGEGLPDEYHTVMATDKDVCDLLIVIGSSLKVRPVAHI-----PSSIPATVPQILI 451
            |::|||||||||.||..:::....|...|||||::|:||:|:|.|.:     |..|     ::||
  Fly   226 GVVKPDIVFFGENLPKRFYSSPEEDFQDCDLLIIMGTSLEVQPFASLVWRPGPRCI-----RLLI 285

  Fly   452 NREQL-------------HHLKF-------DVELLGDSDVIINQICHRLSDNDDCWRQLCCDESV 496
            ||:.:             ..|.|       ||..|||.|..:..:...|.     |.|. ..:.:
  Fly   286 NRDAVGQASCVLFMDPNTRSLLFDKPNNTRDVAFLGDCDAGVMALAKALG-----WDQE-LQQLI 344

  Fly   497 LTESKELMPPEHSNHHLHHHLLHHRHCSSESERQSQLDTDTQSIKSNSSAD 547
            .:|.|:|...::|..            ..:.:.:.|.|.|..:.......|
  Fly   345 TSERKKLSGSQNSEE------------LQQGKEKPQSDPDKMTSGDRDKKD 383

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt1	NP_477351.1	DUF592	<202..228	CDD:282439	6/27 (22%)
		SIRT1	222..476	CDD:238699	113/281 (40%)
Sirt2	NP_001287422.2	SIRT1	79..330	CDD:238699	113/281 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438944
Domainoid	1	1.000	54	1.000	Domainoid score	I647
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D512963at33208
OrthoFinder	1	1.000	-	-		FOG0000643
OrthoInspector	1	1.000	-	-		otm51312
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48252
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R577
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.980