Protein Alignment Sirt1 and Sirt2

DIOPT Version :10

• Sequence 1: NP_477351.1
• Gene: Sirt1 / 34708
• FlyBaseID: FBgn0024291
• Length: 823
• Species: Drosophila melanogaster
• Sequence 2: NP_001386559.1
• Gene: Sirt2 / 361532
• RGDID: 621481
• Length: 388
• Species: Rattus norvegicus
• Alignment Length: 460
• Identity: 146/460 - (31%)
• Similarity: 215/460 - (46%)
• Gaps: 127/460 - (27%)

  Fly   117 EEEEEDDEEGITGTSNEDEDSSSNCSSSVEPDWKLRWLQREFYTGRVPRQVIASIMPHFATGLAG 181
            |.:..|..|...|...|.:||.|:....                               |||  |
  Rat     3 EPDPSDPLENQAGKVQEAQDSDSDTEGG-------------------------------ATG--G 34

  Fly   182 DTDDSVLWDYLAHLLNEPKRRNKLASVNTFDDVISLV--KKSQKIIVLTGAGVSVSCGIPDFRS- 243
            :.:...|.:.....|....::.:|....|.:.|...:  ::.:::|.|.|||:|.|.|||||||
  Rat    35 EAEMDFLRNLFTQTLGLGSQKERLLDELTLEGVTRYMQSERCRRVICLVGAGISTSAGIPDFRSP 99

  Fly   244 TNGIYARLA--HDFPDLPDPQAMFDINYFKRDPRPFYKFAREIYPGEFQPSPCHRFIKMLETKGK 306
            :.|:||.|.  |    ||.|:|:|:|:|||:.|.||:..|:|:|||:|:|:.||.||::|:.||.
  Rat   100 STGLYANLEKYH----LPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFIRLLKEKGL 160

  Fly   307 LLRNYTQNIDTLERVAGI--QRVIECHGSFSTASC--TKCRFKCNADALRADIFAQRIPVCPQCQ 367
            |||.|||||||||||||:  |.::|.||:|.|:.|  |.|..:.....::..||::..|.|.:||
  Rat   161 LLRCYTQNIDTLERVAGLEPQDLVEAHGTFYTSHCVNTSCGKEYTMSWMKEKIFSEATPKCEKCQ 225

  Fly   368 PNKEQSVDASVAVTEEELRQLVENGIMKPDIVFFGEGLPDEYHTVMATDKDVCDLLIVIGSSLKV 432
                                    .::|||||||||.||..:.:.|.:|....||||::|:||:|
  Rat   226 ------------------------NVVKPDIVFFGENLPPRFFSCMQSDFSKVDLLIIMGTSLQV 266

  Fly   433 RPVAHIPSSIPATVPQILINREQLHH--------------LKF-------DVELLGDSDVIINQI 476
            :|.|.:.|..|...|::|||:|:...              :.|       ||..|||.|    |.
  Rat   267 QPFASLISKAPLATPRLLINKEKTGQTDPFLGMMMGLGGGMDFDSKKAYRDVAWLGDCD----QG 327

  Fly   477 CHRLSDNDDCWRQLCCDESVLTESKELMPPEHSNHHLHHHLLHHRHCSSESERQSQLDTDTQSIK 541
            |..|:|... |::         |.::|:..||:|                      :|..:.|..
  Rat   328 CLALADLLG-WKK---------ELEDLVRREHAN----------------------IDAQSGSQA 360

  Fly   542 SNSSA 546
            ||.||
  Rat   361 SNPSA 365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt1	NP_477351.1	SIRT1	222..476	CDD:238699	113/281 (40%)
Sirt2	NP_001386559.1	SIRT1	77..331	CDD:238699	115/285 (40%)