DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sirt1 and sir2

DIOPT Version :9

Sequence 1:	NP_477351.1	Gene:	Sirt1 / 34708	FlyBaseID:	FBgn0024291	Length:	823	Species:	Drosophila melanogaster
Sequence 2:	NP_001018840.1	Gene:	sir2 / 3361342	PomBaseID:	SPBC16D10.07c	Length:	475	Species:	Schizosaccharomyces pombe

Alignment Length:	472	Identity:	171/472 - (36%)
Similarity:	241/472 - (51%)	Gaps:	66/472 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 DEEEEEEDDEEEEEDDEEGITGTSNEDEDSSSNCSSSVEPDWKLRWLQREFYTGRVPRQVIASIM 172
            :.|:||.|.:|.::.:.|.|:     |.|..|.....:......::|::......:|   :.||:
pombe    47 ETEDEEVDSDEWDKPETENIS-----DLDERSEMVRYLRASGYAKFLEKYLIEEELP---VRSIL 103

  Fly   173 PHFATGLAG---DTDDSVLWDYLAHLL-NEPKRRNKLASVNTFDDVISLVKKSQKIIVLTGAGVS 233
            ......|..   :.:|..|...|..:| .|..||.||...|||:||::|:||::.::||.|||:|
pombe   104 KKLGINLPSALEEFEDIDLLPLLKEVLKREVARRIKLPHFNTFEDVVNLLKKAKNVVVLVGAGIS 168

  Fly   234 VSCGIPDFRSTNGIYARLAHDFPDLPDPQAMFDINYFKRDPRPFYKFAREIYPGEFQPSPCHRFI 298
            .|.||.||||.||.|||||..  .|.:|..||||:.|:.:|..||.|||::.|.....||.|.||
pombe   169 TSLGILDFRSDNGFYARLARH--GLSEPSEMFDIHTFRENPEIFYTFARDLLPETNHYSPSHAFI 231

  Fly   299 KMLETKGKLLRNYTQNIDTLERVAGI--QRVIECHGSFSTASCTKCRFKCNADALRADIFAQRIP 361
            ::||.|.||...:|||||.||:..|:  .::|:|||||:||:|.||:.|.:...|..||..||:.
pombe   232 RLLEKKNKLSTLFTQNIDNLEKKTGLSDNKIIQCHGSFATATCIKCKHKVDGSELYEDIRNQRVS 296

  Fly   362 VCPQC-QP---------NKEQSVDASVAVTEEELRQLVENGIMKPDIVFFGEGLPDE-YHTVMAT 415
            .|.:| :|         ||::....|...:|.....|.:.|||||||.||||.|||. ::.|.:.
pombe   297 YCNECGKPPLKLRRVGQNKKEKHYFSDGDSESSEDDLAQPGIMKPDITFFGEALPDSFFNKVGSG 361

  Fly   416 DKDVCDLLIVIGSSLKVRPVAHIPSSIPATVPQILINREQLHHLKFDVELLGD-SDVIINQICHR 479
            :.:..||||.||:||||.||:.:.|.||.|.|||.|:|..:.|.:|||..|.. .|.:|.:||.|
pombe   362 ELEETDLLICIGTSLKVAPVSELISVIPPTTPQIYISRTPVRHTQFDVNFLSPYCDWVIVEICKR 426

  Fly   480 LSDNDDCW---RQLCCDESVLTESKELMPPEHSNHHLHHHLLHHRHCSSESERQSQLDTDTQSIK 541
            ..     |   .|..||          :|..|               |....|..:.|.|   ||
pombe   427 AG-----WLNELQALCD----------LPECH---------------SGSKTRAFETDLD---IK 458

  Fly   542 SNSSADYILGSA--GTC 556
            ....:.|.:.|.  |:|
pombe   459 FEEPSTYHITSTTNGSC 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sirt1	NP_477351.1	DUF592	<202..228	CDD:282439	12/25 (48%)
Sirt1	NP_477351.1	SIRT1	222..476	CDD:238699	120/267 (45%)
sir2	NP_001018840.1	DUF592	70..162	CDD:282439	24/94 (26%)
sir2	NP_001018840.1	SIRT1	157..420	CDD:238699	119/264 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	176	1.000	Domainoid score	I850
eggNOG	1	0.900	-	-		E1_COG0846
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000643
OrthoInspector	1	1.000	-	-		oto101185
orthoMCL	1	0.900	-	-		OOG6_103854
Panther	1	1.100	-	-	LDO	PTHR48252
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R577
SonicParanoid	1	1.000	-	-		X3771
TreeFam	0	0.000	Not matched by this tool.
	9	8.840