DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sirt1 and Sirt1

DIOPT Version :9

Sequence 1:	NP_477351.1	Gene:	Sirt1 / 34708	FlyBaseID:	FBgn0024291	Length:	823	Species:	Drosophila melanogaster
Sequence 2:	XP_038954683.1	Gene:	Sirt1 / 309757	RGDID:	1308542	Length:	741	Species:	Rattus norvegicus

Alignment Length:	765	Identity:	293/765 - (38%)
Similarity:	398/765 - (52%)	Gaps:	159/765 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 GAEILASTSTEAEAEAEATATTTEPAT--SELAG--KANGEIKTKTLAAREEQEIGANLEHKTKN 97
            |....|:.:..|.|..|| |:...||.  .|.||  .|:.|.:....||..:.:.|..|..:.:
  Rat    48 GEPSAAAAAAAAAAGCEA-ASAAAPAALWREAAGAAAASAEREAPATAAAGDGDNGPGLRREPR- 110

  Fly    98 PTKSMGEDEDDEEEEEEDDEE---------------EEEDDEEGITGTSNEDEDSSSNCSSSVEP 147
                ..:|.||:|.||||:..               .:|....|.....::|:|.:|:.|||
  Rat   111 ----AADDFDDDEGEEEDEAAAAAAAAIGYRDNLLLADEIITNGFHSCESDDDDRASHASSS--- 168

  Fly   148 DWKLR-------WLQREFYTGRVPRQVIASIMPHFATGLAGDTDDSVLWDYLAHLLNEPKRRNKL 205
            ||..|       ::|:....|..||.::..::|.  |....:.||..||..:.::|:||.:|.|.
  Rat   169 DWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPE--TIPPPELDDMTLWQIVINILSEPPKRKKR 231

  Fly   206 ASVNTFDDVISLVKKSQKIIVLTGAGVSVSCGIPDFRSTNGIYARLAHDFPDLPDPQAMFDINYF 270
            ..:||.:|.:.|:::.:|||||||||||||||||||||.:|||||||.||||||||||||||.||
  Rat   232 KDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYF 296

  Fly   271 KRDPRPFYKFAREIYPGEFQPSPCHRFIKMLETKGKLLRNYTQNIDTLERVAGIQRVIECHGSFS 335
            ::|||||:|||:|||||:||||.||:||.:.:.:|||||||||||||||:||||||:|:|||||:
  Rat   297 RKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFA 361

  Fly   336 TASCTKCRFKCNADALRADIFAQRIPVCPQCQPNKEQSVDASVAVTEEELRQLVENGIMKPDIVF 400
            ||||..|::|.:.:|:|.|||.|.:|.||:|.             .:|.|      .||||:|||
  Rat   362 TASCLICKYKVDCEAVRGDIFNQVVPRCPRCP-------------ADEPL------AIMKPEIVF 407

  Fly   401 FGEGLPDEYHTVMATDKDVCDLLIVIGSSLKVRPVAHIPSSIPATVPQILINREQLHHLKFDVEL 465
            |||.||:::|..|..|||..||||||||||||||||.||||||..|||||||||.|.||.|||||
  Rat   408 FGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVEL 472

  Fly   466 LGDSDVIINQICHRLSDNDDCWRQLCCDESVLTESKELMPPEHSNHHLHHHLLHHRHCSSESERQ 530
            |||.|||||::||||...   :.:|||:...|:|..| .||......:|               .
  Rat   473 LGDCDVIINELCHRLGGE---YAKLCCNPVKLSEITE-KPPRTQKELVH---------------L 518

  Fly   531 SQLDTDTQSIKSNSSADYILGSAGTCSDSGFESSTFSCGKRSTAAEAAAIERIKTDILVELNETT 595
            |:|......|..:||:.                      :|:...:::.|..:       :::|.
  Rat   519 SELPPTPLHISEDSSSP----------------------ERTVPQDSSVIATL-------VDQTI 554

  Fly   596 ALSCDRLGLEGPQTTVE-------SYRHLSIDSSKDSGIEQCDNEATPSYVRPSNLVQETKTVAP 653
            ....|.|.:..|::.||       :||::     :...:|..|.:|..|.....|   |..:||.
  Rat   555 KNKVDDLEVSEPKSCVEEKSQEVQTYRNV-----ESINVENPDFKAVGSSTGDKN---ERTSVAE 611

  Fly   654 SLTPIPQQRGKRQTAAERLQPGTFYSHTNNYSYVFPGAQVFWDNDYSDDDDEEEERSHNRHSDLF 718
            ::......|..::..::||. |..|.......|:|.||:|     |||.:|:....|
  Rat   612 TVRKCWPNRLAKEQISKRLD-GNQYLFVPPNRYIFHGAEV-----YSDSEDDALSSS-------- 662

  Fly   719 GNVGHNYKDDDEDACDLNAVPLSPLLPPSLEAHIVTDIVNGSNEPLPNSS 768
             :.|.|   .|...|.          .||||            |||.:.|
  Rat   663 -SCGSN---SDSGTCQ----------SPSLE------------EPLEDES 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sirt1	NP_477351.1	DUF592	<202..228	CDD:282439	10/25 (40%)
Sirt1	NP_477351.1	SIRT1	222..476	CDD:238699	174/253 (69%)
Sirt1	XP_038954683.1	SIRT1	248..483	CDD:238699	156/234 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	279	1.000	Domainoid score	I1620
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	420	1.000	Inparanoid score	I1736
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D512963at33208
OrthoFinder	1	1.000	-	-		FOG0000643
OrthoInspector	1	1.000	-	-		otm45380
orthoMCL	1	0.900	-	-		OOG6_103854
Panther	1	1.100	-	-	LDO	PTHR48252
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3771
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.970