Protein Alignment Sirt1 and Sirt1

DIOPT Version :10

• Sequence 1: NP_477351.1
• Gene: Sirt1 / 34708
• FlyBaseID: FBgn0024291
• Length: 823
• Species: Drosophila melanogaster
• Sequence 2: NP_001401888.1
• Gene: Sirt1 / 309757
• RGDID: 1308542
• Length: 741
• Species: Rattus norvegicus
• Alignment Length: 765
• Identity: 293/765 - (38%)
• Similarity: 398/765 - (52%)
• Gaps: 159/765 - (20%)

  Fly    37 GAEILASTSTEAEAEAEATATTTEPAT--SELAG--KANGEIKTKTLAAREEQEIGANLEHKTKN 97
            |....|:.:..|.|..|| |:...||.  .|.||  .|:.|.:....||..:.:.|..|..:.:
  Rat    48 GEPSAAAAAAAAAAGCEA-ASAAAPAALWREAAGAAAASAEREAPATAAAGDGDNGPGLRREPR- 110

  Fly    98 PTKSMGEDEDDEEEEEEDDEE---------------EEEDDEEGITGTSNEDEDSSSNCSSSVEP 147
                ..:|.||:|.||||:..               .:|....|.....::|:|.:|:.|||
  Rat   111 ----AADDFDDDEGEEEDEAAAAAAAAIGYRDNLLLADEIITNGFHSCESDDDDRASHASSS--- 168

  Fly   148 DWKLR-------WLQREFYTGRVPRQVIASIMPHFATGLAGDTDDSVLWDYLAHLLNEPKRRNKL 205
            ||..|       ::|:....|..||.::..::|.  |....:.||..||..:.::|:||.:|.|.
  Rat   169 DWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPE--TIPPPELDDMTLWQIVINILSEPPKRKKR 231

  Fly   206 ASVNTFDDVISLVKKSQKIIVLTGAGVSVSCGIPDFRSTNGIYARLAHDFPDLPDPQAMFDINYF 270
            ..:||.:|.:.|:::.:|||||||||||||||||||||.:|||||||.||||||||||||||.||
  Rat   232 KDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYF 296

  Fly   271 KRDPRPFYKFAREIYPGEFQPSPCHRFIKMLETKGKLLRNYTQNIDTLERVAGIQRVIECHGSFS 335
            ::|||||:|||:|||||:||||.||:||.:.:.:|||||||||||||||:||||||:|:|||||:
  Rat   297 RKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFA 361

  Fly   336 TASCTKCRFKCNADALRADIFAQRIPVCPQCQPNKEQSVDASVAVTEEELRQLVENGIMKPDIVF 400
            ||||..|::|.:.:|:|.|||.|.:|.||:|.             .:|.|      .||||:|||
  Rat   362 TASCLICKYKVDCEAVRGDIFNQVVPRCPRCP-------------ADEPL------AIMKPEIVF 407

  Fly   401 FGEGLPDEYHTVMATDKDVCDLLIVIGSSLKVRPVAHIPSSIPATVPQILINREQLHHLKFDVEL 465
            |||.||:::|..|..|||..||||||||||||||||.||||||..|||||||||.|.||.|||||
  Rat   408 FGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVEL 472

  Fly   466 LGDSDVIINQICHRLSDNDDCWRQLCCDESVLTESKELMPPEHSNHHLHHHLLHHRHCSSESERQ 530
            |||.|||||::||||...   :.:|||:...|:|..| .||......:|               .
  Rat   473 LGDCDVIINELCHRLGGE---YAKLCCNPVKLSEITE-KPPRTQKELVH---------------L 518

  Fly   531 SQLDTDTQSIKSNSSADYILGSAGTCSDSGFESSTFSCGKRSTAAEAAAIERIKTDILVELNETT 595
            |:|......|..:||:.                      :|:...:::.|..:       :::|.
  Rat   519 SELPPTPLHISEDSSSP----------------------ERTVPQDSSVIATL-------VDQTI 554

  Fly   596 ALSCDRLGLEGPQTTVE-------SYRHLSIDSSKDSGIEQCDNEATPSYVRPSNLVQETKTVAP 653
            ....|.|.:..|::.||       :||::     :...:|..|.:|..|.....|   |..:||.
  Rat   555 KNKVDDLEVSEPKSCVEEKSQEVQTYRNV-----ESINVENPDFKAVGSSTGDKN---ERTSVAE 611

  Fly   654 SLTPIPQQRGKRQTAAERLQPGTFYSHTNNYSYVFPGAQVFWDNDYSDDDDEEEERSHNRHSDLF 718
            ::......|..::..::||. |..|.......|:|.||:|     |||.:|:....|
  Rat   612 TVRKCWPNRLAKEQISKRLD-GNQYLFVPPNRYIFHGAEV-----YSDSEDDALSSS-------- 662

  Fly   719 GNVGHNYKDDDEDACDLNAVPLSPLLPPSLEAHIVTDIVNGSNEPLPNSS 768
             :.|.|   .|...|.          .||||            |||.:.|
  Rat   663 -SCGSN---SDSGTCQ----------SPSLE------------EPLEDES 686

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt1	NP_477351.1	SIRT1	222..476	CDD:238699	174/253 (69%)
Sirt1	NP_001401888.1	SIRT1	248..483	CDD:238699	156/234 (67%)