Protein Alignment Sirt1 and Sirt5

DIOPT Version :10

• Sequence 1: NP_477351.1
• Gene: Sirt1 / 34708
• FlyBaseID: FBgn0024291
• Length: 823
• Species: Drosophila melanogaster
• Sequence 2: NP_001004256.1
• Gene: Sirt5 / 306840
• RGDID: 1303285
• Length: 310
• Species: Rattus norvegicus
• Alignment Length: 288
• Identity: 74/288 - (25%)
• Similarity: 120/288 - (41%)
• Gaps: 86/288 - (29%)

  Fly   221 SQKIIVLTGAGVSVSCGIPDFRSTNGIYAR--LAHDFPDLPDPQAMFDINYFKRDPR---PFYKF 280
            ::.|::::|||||...|:|.||.|.|.:.:  ..|    |..|.|      |..:|.   .||.:
  Rat    50 AKHIVIISGAGVSAESGVPTFRGTGGYWRKWQAQH----LATPLA------FAHNPSQVWEFYHY 104

  Fly   281 AREIYPGEFQPSPCHRFIKMLETK----GKLLRNYTQNIDTLERVAGIQRVIECHGSFSTASCTK 341
            .||:...: :|:|.|..|...|.:    |:.:...|||||.|.|.||.:.::|.||:.....||.
  Rat   105 RREVMRNK-EPNPGHLAIAQCEARLRDQGRRVVVITQNIDELHRKAGTKNLLEIHGTLFKTRCTS 168

  Fly   342 C-----RFKCNADALRADIFAQRIPVCPQC------QPNKEQSVDASVAVTEEELRQLVE---NG 392
            |     .:|.              |:||..      :|:.::|     .:...:|.:..|   .|
  Rat   169 CGNVAENYKS--------------PICPALLGKGAPEPDTQES-----RIPVHKLPRCEEAGCGG 214

  Fly   393 IMKPDIVFFGEGLPDEYHTVMATDKDV--CDLLIVIGSSLKVRPVA------------------- 436
            :::|.:|:|||.|  :...:...|:::  |||.:|:|:|..|.|.|
  Rat   215 LLRPHVVWFGENL--DPAILKEVDRELARCDLCLVVGTSSVVYPAAMFAPQVASRGVPVAEFNME 277

  Fly   437 ----------HIPSSIPATVPQILINRE 454
                      |.|.....|:|:.|...|
  Rat   278 TTPATNRFRFHFPGPCGVTLPEALAPHE 305

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt1	NP_477351.1	SIRT1	222..476	CDD:238699	74/287 (26%)
Sirt5	NP_001004256.1	SIRT5_Af1_CobB	51..301	CDD:238703	72/281 (26%)