Protein Alignment Sirt1 and Sirt3

DIOPT Version :9

• Sequence 1: NP_477351.1
• Gene: Sirt1 / 34708
• FlyBaseID: FBgn0024291
• Length: 823
• Species: Drosophila melanogaster
• Sequence 2: XP_006230588.1
• Gene: Sirt3 / 293615
• RGDID: 1308374
• Length: 334
• Species: Rattus norvegicus
• Alignment Length: 283
• Identity: 109/283 - (38%)
• Similarity: 165/283 - (58%)
• Gaps: 41/283 - (14%)

  Fly   210 TFDDVISLV--KKSQKIIVLTGAGVSVSCGIPDFRST-NGIYARLAHDFPDLPDPQAMFDINYFK 271
            :..||..|:  :...:::|:.|||:|...|||||||. :|:|:.|..  .|:|.|:|:|::.:|.
  Rat    59 SLQDVAELLRTRACSRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQ--YDIPYPEAIFELGFFF 121

  Fly   272 RDPRPFYKFAREIYPGEFQPSPCHRFIKMLETKGKLLRNYTQNIDTLERVAGI--QRVIECHGSF 334
            .:|:||:..|:|:|||.::|:..|.|:::|..|..|||.||||||.|||.:||  .:::|.||||
  Rat   122 HNPKPFFTLAKELYPGHYRPNVAHYFLRLLHDKELLLRLYTQNIDGLERASGIPASKLVEAHGSF 186

  Fly   335 STASCTKCRFKCNADALRADIFAQRIPVCPQCQPNKEQSVDASVAVTEEELRQLVENGIMKPDIV 399
            .:|:||.||.....:.:|||:.|.|:|.||.|                        .|::|||||
  Rat   187 VSATCTVCRRSFPGEDIRADVMADRVPRCPVC------------------------TGVVKPDIV 227

  Fly   400 FFGEGLPDEYHTVMATDKDVCDLLIVIGSSLKVRPVAHIPSSIPATVPQILINRE-----QLHHL 459
            ||||.||..: .:...|..:.|||:::|:||:|.|.|.:..|:..:||::||||:     .|...
  Rat   228 FFGEQLPARF-LLHVADFALADLLLILGTSLEVEPFASLSESVQKSVPRLLINRDLVGSFALSPR 291

  Fly   460 KFDVELLGDSDVIINQICHRLSD 482
            :.||..|||    :.|...||.|
  Rat   292 RKDVVQLGD----VVQGVERLVD 310

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt1	NP_477351.1	DUF592	<202..228	CDD:282439	4/19 (21%)
		SIRT1	222..476	CDD:238699	102/261 (39%)
Sirt3	XP_006230588.1	SIRT1	74..308	CDD:238699	103/264 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0846
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D512963at33208
OrthoFinder	1	1.000	-	-		FOG0000643
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820