Protein Alignment Sirt1 and SIRT4

DIOPT Version :10

• Sequence 1: NP_477351.1
• Gene: Sirt1 / 34708
• FlyBaseID: FBgn0024291
• Length: 823
• Species: Drosophila melanogaster
• Sequence 2: NP_036372.1
• Gene: SIRT4 / 23409
• HGNCID: 14932
• Length: 314
• Species: Homo sapiens
• Alignment Length: 248
• Identity: 76/248 - (30%)
• Similarity: 108/248 - (43%)
• Gaps: 72/248 - (29%)

  Fly   221 SQKIIVLTGAGVSVSCGIPDFRSTN-GIYAR-----LAH-DF-PDLPDPQAMFDINYFKRDPRPF 277
            |::::|:||||:|...||||:||.. |:|||     :.| || ...|..|     .|:.|:...:
Human    54 SKRLLVMTGAGISTESGIPDYRSEKVGLYARTDRRPIQHGDFVRSAPIRQ-----RYWARNFVGW 113

  Fly   278 YKFAREIYPGEFQPSPCHRFIKMLETKGKLLRNYTQNIDTLERVAGIQRVIECHGSFSTASCTKC 342
            .:|:      ..||:|.|..:...|..|||....|||:|.|...||.:|:.|.||......|..|
Human   114 PQFS------SHQPNPAHWALSTWEKLGKLYWLVTQNVDALHTKAGSRRLTELHGCMDRVLCLDC 172

  Fly   343 -----------RFK-------CNADALR--ADIFAQ-------RIPVCPQCQPNKEQSVDASVAV 380
                       ||:       ..|..|.  .|:|..       ::|.|.||
Human   173 GEQTPRGVLQERFQVLNPTWSAEAHGLAPDGDVFLSEEQVRSFQVPTCVQC-------------- 223

  Fly   381 TEEELRQLVENGIMKPDIVFFGEGL-PDEYHTVMATDKDVCDLLIVIGSSLKV 432
                      .|.:|||:||||:.: ||:...|....|: .|.|:|:||||:|
Human   224 ----------GGHLKPDVVFFGDTVNPDKVDFVHKRVKE-ADSLLVVGSSLQV 265

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt1	NP_477351.1	SIRT1	222..476	CDD:238699	75/247 (30%)
SIRT4	NP_036372.1	SIRT4	47..308	CDD:238700	76/248 (31%)
		sirtuin core domain	55..314		75/247 (30%)