Protein Alignment Sirt1 and SIRT2

DIOPT Version :9

• Sequence 1: NP_477351.1
• Gene: Sirt1 / 34708
• FlyBaseID: FBgn0024291
• Length: 823
• Species: Drosophila melanogaster
• Sequence 2: NP_036369.2
• Gene: SIRT2 / 22933
• HGNCID: 10886
• Length: 389
• Species: Homo sapiens
• Alignment Length: 363
• Identity: 125/363 - (34%)
• Similarity: 196/363 - (53%)
• Gaps: 71/363 - (19%)

  Fly   178 GLAGDTDDSVLWDYLAHLLNEP----KRRNKLASVNTFDDVISLV--KKSQKIIVLTGAGVSVSC 236
            |.||...|   .|:|.:|.::.    .::.:|....|.:.|...:  ::.:::|.|.|||:|.|.
Human    30 GAAGGEAD---MDFLRNLFSQTLSLGSQKERLLDELTLEGVARYMQSERCRRVICLVGAGISTSA 91

  Fly   237 GIPDFRS-TNGIYARLA--HDFPDLPDPQAMFDINYFKRDPRPFYKFAREIYPGEFQPSPCHRFI 298
            ||||||| :.|:|..|.  |    ||.|:|:|:|:|||:.|.||:..|:|:|||:|:|:.||.|:
Human    92 GIPDFRSPSTGLYDNLEKYH----LPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFM 152

  Fly   299 KMLETKGKLLRNYTQNIDTLERVAGIQR--VIECHGSFSTASC--TKCRFKCNADALRADIFAQR 359
            ::|:.||.|||.||||||||||:||:::  ::|.||:|.|:.|  ..||.:.....::..||::.
Human   153 RLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEV 217

  Fly   360 IPVCPQCQPNKEQSVDASVAVTEEELRQLVENGIMKPDIVFFGEGLPDEYHTVMATDKDVCDLLI 424
            .|.|..||                        .::|||||||||.||..:.:.|.:|....|||:
Human   218 TPKCEDCQ------------------------SLVKPDIVFFGESLPARFFSCMQSDFLKVDLLL 258

  Fly   425 VIGSSLKVRPVAHIPSSIPATVPQILINREQLHHLKFDVELLGDSDVIINQICHRLS----DNDD 485
            |:|:||:|:|.|.:.|..|.:.|::|||:|:          .|.||..:..|.....    |:..
Human   259 VMGTSLQVQPFASLISKAPLSTPRLLINKEK----------AGQSDPFLGMIMGLGGGMDFDSKK 313

  Fly   486 CWRQLC----CDESVLT---------ESKELMPPEHSN 510
            .:|.:.    ||:..|.         |.::|:..||::
Human   314 AYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHAS 351

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt1	NP_477351.1	DUF592	<202..228	CDD:282439	4/27 (15%)
		SIRT1	222..476	CDD:238699	105/260 (40%)
SIRT2	NP_036369.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..34		2/3 (67%)
		Nuclear export signal	41..51		2/9 (22%)
		SIRT1	77..331	CDD:238699	111/291 (38%)
		Peptide inhibitor binding	116..120		1/3 (33%)
		Peptide inhibitor binding	232..301		30/78 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	351..389		0/1 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0846
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D512963at33208
OrthoFinder	1	1.000	-	-		FOG0000643
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820