Protein Alignment Sirt1 and Sirt7

DIOPT Version :10

• Sequence 1: NP_477351.1
• Gene: Sirt1 / 34708
• FlyBaseID: FBgn0024291
• Length: 823
• Species: Drosophila melanogaster
• Sequence 2: NP_694696.2
• Gene: Sirt7 / 209011
• MGIID: 2385849
• Length: 402
• Species: Mus musculus
• Alignment Length: 277
• Identity: 64/277 - (23%)
• Similarity: 97/277 - (35%)
• Gaps: 93/277 - (33%)

  Fly   190 DYLAHLLNEPKRRN--KLASVNTFDD----------VISLVKKSQKIIVLTGAGVSVSCGIPDFR 242
            |.:..|....:||.  |.......||          :...|:.::.::|.||||:|.:..|||:|
Mouse    57 DLVTELQGRSRRREGLKRRQEEVCDDPEELRRKVRELAGAVRSARHLVVYTGAGISTAASIPDYR 121

  Fly   243 STNGIYARLAHDFP----DLPDPQAMFDINYFKRDPRPFYKFAREIYPGEFQPSPCHRFIKMLET 303
            ..||::..|....|    ||                            .|.:|:..|..|..|..
Mouse   122 GPNGVWTLLQKGRPVSAADL----------------------------SEAEPTLTHMSITRLHE 158

  Fly   304 KGKLLRNYTQNIDTLERVAGIQR--VIECHGSFSTASCTKCRFKCNADALRADIFAQRIPVCPQC 366
            :..:....:||.|.|...:|:.|  :.|.||:                        ..|.||..|
Mouse   159 QKLVQHVVSQNCDGLHLRSGLPRTAISELHGN------------------------MYIEVCTSC 199

  Fly   367 QPNKEQSVDASVAVTEEELRQLVENGI-----------MKPDIVFFGE----GLPDEYHTVMATD 416
            .||:|.     |.|.:...|..:...:           ::..||.|||    |.|..:..  ||:
Mouse   200 IPNREY-----VRVFDVTERTALHRHLTGRTCHKCGTQLRDTIVHFGERGTLGQPLNWEA--ATE 257

  Fly   417 -KDVCDLLIVIGSSLKV 432
             ....|.::.:||||||
Mouse   258 AASKADTILCLGSSLKV 274

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt1	NP_477351.1	SIRT1	222..476	CDD:238699	56/233 (24%)
Sirt7	NP_694696.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23
		DUF5401	<11..>91	CDD:375164	7/33 (21%)
		SIRT7	102..315	CDD:238701	56/232 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	355..402