Protein Alignment Sirt1 and sir-2.3

DIOPT Version :9

• Sequence 1: NP_477351.1
• Gene: Sirt1 / 34708
• FlyBaseID: FBgn0024291
• Length: 823
• Species: Drosophila melanogaster
• Sequence 2: NP_510220.1
• Gene: sir-2.3 / 185876
• WormBaseID: WBGene00004802
• Length: 287
• Species: Caenorhabditis elegans
• Alignment Length: 297
• Identity: 76/297 - (25%)
• Similarity: 126/297 - (42%)
• Gaps: 60/297 - (20%)

  Fly   209 NTFDDVISLVKKSQKIIVLTGAGVSVSCGIPDFRSTN-GIYARLAHD---FPDLPDPQAMFDINY 269
            |:.....|||....|::::||||:|...||||:||.: |:|.:.|.:   |.|....:.... .|
 Worm    15 NSLKKFKSLVGTVDKLLIITGAGISTESGIPDYRSKDVGLYTKTALEPIYFQDFMKSKKCRQ-RY 78

  Fly   270 FKRDPRPFYKFAREIYPGEFQPSPCHRFIKMLETKGKLLRNYTQNIDTLERVAGIQRVIECHGSF 334
            :.|....:.:||:.:      |:..|..:...|...|.....|||:|.|...||.:.:.|.||:.
 Worm    79 WSRSYLNWPRFAQAL------PNFNHYALSKWEAANKFHWLITQNVDGLHLKAGSKMITELHGNA 137

  Fly   335 STASCTKCRF----KCNADALRADIFAQRIPVCPQCQPN-KEQSV---------DASVAVTEEEL 385
            ....||.|.:    :...|.|.            ...|. |||.|         |.::.:..|:.
 Worm   138 LQVKCTSCEYIETRQTYQDRLN------------YANPGFKEQFVSPGQQELDADTALPLGSEQG 190

  Fly   386 RQLVE----NGIMKPDIVFFGEGLPDEYHTVMATDKDVCDLLIVIGSSLKVRP------VAHIPS 440
            .::.|    .|:||.|:..|||.|..:...|.....:.|:.::.:|:||:|..      .||:.:
 Worm   191 FKIPECLNCGGLMKTDVTLFGENLNTDKIKVCGKKVNECNGVLTLGTSLEVLSGYQIVNHAHMQN 255

  Fly   441 SIPATVPQILIN-----REQLHHLKFDVELLGDSDVI 472
            .     |..::|     .:|:..:|.|..:   |||:
 Worm   256 K-----PIFIVNIGPTRADQMATMKLDYRI---SDVL 284

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt1	NP_477351.1	DUF592	<202..228	CDD:282439	5/18 (28%)
		SIRT1	222..476	CDD:238699	72/284 (25%)
sir-2.3	NP_510220.1	SIRT4	20..284	CDD:238700	74/290 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0846
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810