Protein Alignment Sirt1 and sir-2.4

DIOPT Version :9

• Sequence 1: NP_477351.1
• Gene: Sirt1 / 34708
• FlyBaseID: FBgn0024291
• Length: 823
• Species: Drosophila melanogaster
• Sequence 2: NP_491733.2
• Gene: sir-2.4 / 182284
• WormBaseID: WBGene00004803
• Length: 292
• Species: Caenorhabditis elegans
• Alignment Length: 319
• Identity: 75/319 - (23%)
• Similarity: 128/319 - (40%)
• Gaps: 66/319 - (20%)

  Fly   185 DSVLWDYL-AHLLNEPKRRN-------KLASVNTFDDVISLVKKSQKIIVLTGAGVSVSCGIPDF 241
            :|:|.||. ..::.:|:.|:       ||.::  ::..:...:..:.|.||.|||||....:|||
 Worm     6 ESLLSDYPDKGVIGKPEIRDTETEIIEKLRTL--YNHFVQAKQTGKPIFVLIGAGVSTGSKLPDF 68

  Fly   242 RSTNGIYARLAHDFPDLPDPQAMFDINYFKRDPRPFYKFAREIYPGEFQ---PSPCHRFIKMLET 303
            |...|::...|..                        |.|..:   :||   |...|:.|..|..
 Worm    69 RGKQGVWTLQAEG------------------------KHAEGV---DFQVARPGVSHKSILALHK 106

  Fly   304 KGKLLRNYTQNIDTLERVAGI--QRVIECHGSFSTASCTKCRFKCNADALRADIFAQRIPVCP-- 364
            .|.:....|||:|.|:|..||  :.:||.||:.....|.    .|.::.:|.:| ...:.:||
 Worm   107 AGYIKTIITQNVDGLDRKVGIPVEDLIEVHGNLFLEVCQ----SCFSEYVREEI-VMSVGLCPTG 166

  Fly   365 -QCQPNKEQSVDASVAVTEEELRQLVENGIMKPDIVFFGEGLPDEYHTVMATDKDVCDLLIVIGS 428
             .|:.||.         |....|..:.:..:..|.    |...:....:....|....|| .||:
 Worm   167 RNCEGNKR---------TGRSCRGKLRDATLDWDT----EISLNHLDRIRKAWKQTSHLL-CIGT 217

  Fly   429 SLKVRPVAHIPSSIPAT-VPQILINREQLHHLKF-DVELLGDSDVIINQICHRLSDNDD 485
            ||::.|:..:|....:. :....||.::..|.|. :..:..|..:|:..:|:.|..|.|
 Worm   218 SLEIIPMGSLPLDAKSKGIKTTTINYQETAHEKIVETAIHADVKLILYSLCNALGVNVD 276

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt1	NP_477351.1	DUF592	<202..228	CDD:282439	5/32 (16%)
		SIRT1	222..476	CDD:238699	63/263 (24%)
sir-2.4	NP_491733.2	SIR2	49..259	CDD:294129	61/255 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0846
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810