Protein Alignment Sirt1 and sir-2.2

DIOPT Version :10

• Sequence 1: NP_477351.1
• Gene: Sirt1 / 34708
• FlyBaseID: FBgn0024291
• Length: 823
• Species: Drosophila melanogaster
• Sequence 2: NP_001367227.1
• Gene: sir-2.2 / 181455
• WormBaseID: WBGene00004801
• Length: 294
• Species: Caenorhabditis elegans
• Alignment Length: 313
• Identity: 77/313 - (24%)
• Similarity: 122/313 - (38%)
• Gaps: 90/313 - (28%)

  Fly   209 NTFDDVISLVKKSQKIIVLTGAGVSVSC--GIPDFRSTN-GIYARLAHDFPDLPDPQAMFDINYF 270
            |:....|||:....|::|::|||:|...  ||||:||.: |:|||:||        :.::..:|.
 Worm    20 NSLKKFISLIGTVDKLLVISGAGISTESVPGIPDYRSKDVGLYARIAH--------KPIYFQDYM 76

  Fly   271 KRD-------PRPFYKFAREIYPGEFQPSPCHRFIKMLETKGKLLRNYTQNIDTLERVAGIQRVI 328
            :.:       .|.|..:.|.   |:..|:..|..:...|...:.....|||:|.|...||.:.|.
 Worm    77 RSNRCRQRYWSRNFLAWPRF---GQAAPNINHYALSKWEASDRFQWLITQNVDGLHLKAGSKMVT 138

  Fly   329 ECHGSFSTASCTKCRF----KCNADAL-------------------RADIFAQ-------RIPVC 363
            |.|||.....||.|.:    :...|.|                   ..||...       :||.|
 Worm   139 ELHGSALQVKCTTCDYIESRQTYQDRLDYANPGFKEEHVAPGELAPDGDIILPLGTEKGFQIPEC 203

  Fly   364 PQCQPNKEQSVDASVAVTEEELRQLVENGIMKPDIVFFGEGLPDEYHTVMATDKDVCDLLIVIGS 428
            |.|                        .|:||.|:.||||.:..:.........:.||.::.:|:
 Worm   204 PSC------------------------GGLMKTDVTFFGENVNMDKVNFCYEKVNECDGILSLGT 244

  Fly   429 SLKV----RPVAHIPSSIPATVPQILIN-----REQLHHLKFDVELLGDSDVI 472
            ||.|    |.:.|....   ..|..::|     .:.:..:|.|.::   |||:
 Worm   245 SLAVLSGFRFIHHANMK---KKPIFIVNIGPTRADHMATMKLDYKI---SDVL 291

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt1	NP_477351.1	SIRT1	222..476	CDD:238699	73/300 (24%)
sir-2.2	NP_001367227.1	SIRT4	27..291	CDD:238700	74/304 (24%)