Protein Alignment Sirt1 and sirt2

DIOPT Version :9

• Sequence 1: NP_477351.1
• Gene: Sirt1 / 34708
• FlyBaseID: FBgn0024291
• Length: 823
• Species: Drosophila melanogaster
• Sequence 2: XP_002935827.4
• Gene: sirt2 / 100489469
• XenbaseID: XB-GENE-987375
• Length: 397
• Species: Xenopus tropicalis
• Alignment Length: 422
• Identity: 138/422 - (32%)
• Similarity: 210/422 - (49%)
• Gaps: 103/422 - (24%)

  Fly   109 EEEEEEDDEEEEEDDEEGITGTSNEDEDSSSNCSSSVEPDWKLRWLQREFYTGRVPRQVIASIMP 173
            |..:..|...:.||         :||.|||.:.|.:.|.|: ||.|
 Frog    22 EASKPADLTAQAED---------SEDSDSSEDISGASEMDY-LRNL------------------- 57

  Fly   174 HFATGLAGDTDDSVLWDYLAHLLNEPKRRNKLASVNTFDDVISLVKKSQKIIVLTGAGVSVSCGI 238
             |:..|...|.:.|| |.|:           :..::.|    .|.:|.:.::.:.|||:|.|.||
 Frog    58 -FSRTLGIGTPEKVL-DELS-----------IEGISRF----MLSEKCKNVVCMVGAGISTSAGI 105

  Fly   239 PDFRST-NGIYARLAHDFPDLPDPQAMFDINYFKRDPRPFYKFAREIYPGEFQPSPCHRFIKMLE 302
            |||||. :|:|:.|..  .:||.|:|:|.|.|||.:|.||:..|||::||:|:|:.||.||::|:
 Frog   106 PDFRSPGSGLYSNLQK--YNLPYPEAIFQIGYFKENPEPFFALARELFPGQFKPTICHYFIRLLK 168

  Fly   303 TKGKLLRNYTQNIDTLERVAGI--QRVIECHGSFSTASC--TKCRFKCNADALRADIFAQRIPVC 363
            .||.|||.|:|||||||||||:  ..::|.||:|.::.|  |.||.:.:...::..||:..||.|
 Frog   169 EKGLLLRCYSQNIDTLERVAGLTSDDLVEAHGTFHSSHCVDTFCRAEYSLSWMKEKIFSDLIPKC 233

  Fly   364 PQCQPNKEQSVDASVAVTEEELRQLVENGIMKPDIVFFGEGLPDEYHTVMATDKDVCDLLIVIGS 428
            .:|                        |.::|||||||||.||..:.:.:.:|....|||||:|:
 Frog   234 EKC------------------------NNLVKPDIVFFGESLPSRFFSAIKSDFPKVDLLIVMGT 274

  Fly   429 SLKVRPVAHIPSSIPATVPQILINREQLHHLKFDVELLGDSDVIINQICHRLS---DNDDCWRQL 490
            ||:|:|.|.:.|.:.:..|::|||:          ||.|..|...:.......   |::..:|.:
 Frog   275 SLQVQPFASLVSKVSSKTPRLLINK----------ELAGQGDPFFSVFGFGGGMDFDSEKAYRDV 329

  Fly   491 C----CDESVL---------TESKELMPPEHS 509
            .    ||:..|         .|.:||:..||:
 Frog   330 AWLGDCDDGCLALADFLGWKAELEELVKKEHA 361

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt1	NP_477351.1	DUF592	<202..228	CDD:282439	3/25 (12%)
		SIRT1	222..476	CDD:238699	103/258 (40%)
sirt2	XP_002935827.4	SIRT1	89..342	CDD:238699	108/288 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D512963at33208
OrthoFinder	1	1.000	-	-		FOG0000643
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R577
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.040