Protein Alignment Sirt1 and sirt3

DIOPT Version :10

• Sequence 1: NP_477351.1
• Gene: Sirt1 / 34708
• FlyBaseID: FBgn0024291
• Length: 823
• Species: Drosophila melanogaster
• Sequence 2: XP_012817602.2
• Gene: sirt3 / 100487410
• XenbaseID: XB-GENE-990389
• Length: 358
• Species: Xenopus tropicalis
• Alignment Length: 332
• Identity: 115/332 - (34%)
• Similarity: 176/332 - (53%)
• Gaps: 59/332 - (17%)

  Fly   130 TSNEDEDSSSNCSSSVEPDWKLRWLQREFYTGRVPRQVIASIMPHFATGLAGDTDDSVLWDYLAH 194
            |..:|: .|:..|.:|.|...| ..:|..|:.:...|...|..|    |..||:.::.|
 Frog    36 TVRQDQ-LSARTSGNVPPAQSL-CSRRNIYSHKCRAQWQNSAHP----GGGGDSRNTCL------ 88

  Fly   195 LLNEPKRRNKLASVNTFDDVISLVKKS--QKIIVLTGAGVSVSCGIPDFRS-TNGIYARLAHDFP 256
                           :.:|:...:|:.  ::|:|:.|||:|...||||||| |:|:|:||..  .
 Frog    89 ---------------SLEDIALRIKEGLYRRILVMVGAGISTDSGIPDFRSPTSGLYSRLQE--Y 136

  Fly   257 DLPDPQAMFDINYFKRDPRPFYKFAREIYPGEFQPSPCHRFIKMLETKGKLLRNYTQNIDTLERV 321
            :||.|:|:||:.||.|:|:||...||::.||...|:..|.|:::|..|..|||.||||||.|||.
 Frog   137 NLPYPEAIFDLRYFLREPQPFLHLARDLLPGHHHPNTAHHFLRLLSDKEVLLRLYTQNIDGLERA 201

  Fly   322 AGI--QRVIECHGSFSTASCTKCRFKCNADALRADIFAQRIPVCPQCQPNKEQSVDASVAVTEEE 384
            |||  ::::|.|||||:|:||.|......:..:..:...::|:|..|
 Frog   202 AGIPSEKLVEAHGSFSSATCTMCLKSYPGETFQKAVMESKVPLCSSC------------------ 248

  Fly   385 LRQLVENGIMKPDIVFFGEGLPDEYHTVMATDKDVCDLLIVIGSSLKVRPVAHIPSSIPATVPQI 449
                  .|::|.|||||||.||..: .:..||....|||.|||:||:|.|.|.:..::.|:.|::
 Frog   249 ------GGLIKADIVFFGEQLPPRF-LLHLTDFPRADLLFVIGTSLEVEPFASLVYAVRASTPRV 306

  Fly   450 LINREQL 456
            ||||:.:
 Frog   307 LINRDSV 313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt1	NP_477351.1	SIRT1	222..476	CDD:238699	97/238 (41%)
sirt3	XP_012817602.2	SIR2	103..337	CDD:444738	97/238 (41%)