Protein Alignment Sirt1 and sirt5

DIOPT Version :10

• Sequence 1: NP_477351.1
• Gene: Sirt1 / 34708
• FlyBaseID: FBgn0024291
• Length: 823
• Species: Drosophila melanogaster
• Sequence 2: NP_001263631.1
• Gene: sirt5 / 100170199
• XenbaseID: XB-GENE-5892372
• Length: 309
• Species: Xenopus tropicalis
• Alignment Length: 255
• Identity: 83/255 - (32%)
• Similarity: 121/255 - (47%)
• Gaps: 46/255 - (18%)

  Fly   220 KSQKIIVLTGAGVSVSCGIPDFRSTNGIYAR--LAHDFPDLPDPQAMFDINYFKRDPR---PFYK 279
            |::.|.|:||||||...|:|.||...|.:.:  ..|    |..|:|      |.|:|.   .||.
 Frog    48 KAKHIAVITGAGVSAESGVPTFRGAGGYWRKWQAQH----LATPEA------FARNPSRVWEFYH 102

  Fly   280 FAREIYPGEFQPSPCHRFIKMLETK----GKLLRNYTQNIDTLERVAGIQRVIECHGSFSTASCT 340
            :.||:...: .|:|.|..|...||:    |:.|...|||||.|.|.||.:.:.|.|||.....||
 Frog   103 YRREVMLTK-NPNPAHLAIAECETRLRKQGRKLVVITQNIDELHRKAGSRNLFEIHGSLFKTRCT 166

  Fly   341 KC-RFKCNADALRADIFAQRIPVCPQC------QPNKEQSVDASVAVTEEELRQLVE---NGIMK 395
            .| ..|.|          .:.|:||..      :|:.:   ||.:.|  |:|.:..|   ||:::
 Frog   167 SCGSVKEN----------YKSPICPALAGKGAPEPDVQ---DAKIPV--EQLPRCDENGCNGLLR 216

  Fly   396 PDIVFFGEGLPDEYHTVMATDKDVCDLLIVIGSSLKVRPVAHIPSSIPAT-VPQILINRE 454
            |::|:|||.|.......:..:.::|||.:|:|:|..|.|.|.....:.|. ||....|.|
 Frog   217 PNVVWFGETLDSNLLGEVEKELEICDLCVVVGTSSVVYPAAMFAPQVAARGVPVAEFNME 276

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sirt1	NP_477351.1	SIRT1	222..476	CDD:238699	82/253 (32%)
sirt5	NP_001263631.1	SIRT5_Af1_CobB	50..300	CDD:238703	82/253 (32%)