DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sirt1 and sirt1

DIOPT Version :9

Sequence 1:	NP_477351.1	Gene:	Sirt1 / 34708	FlyBaseID:	FBgn0024291	Length:	823	Species:	Drosophila melanogaster
Sequence 2:	XP_012821550.2	Gene:	sirt1 / 100145679	XenbaseID:	XB-GENE-989003	Length:	765	Species:	Xenopus tropicalis

Alignment Length:	735	Identity:	275/735 - (37%)
Similarity:	384/735 - (52%)	Gaps:	157/735 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 SELAG-KANGEIKTKTLAA--REEQEIGANLEHKTKNPTKS------------MGEDEDDEEEEE 113
            |:|.| ::.|:.....:||  :||.|..:.:|.|::....|            .|::|...||..
Frog   108 SQLVGAESEGKAALPPIAASLQEEGEASSAMESKSRAHNGSGFQGLPLGTYLVQGQEEGGAEEMP 172

  Fly   114 EDDEEEE----------EDD-EEGITGTSNEDEDSSSNCSSSVEPDWKLR-------WLQREFYT 160
            ..|..::          :|| ..|.....:||:|.:|:.|||   ||..|       ::||....
Frog   173 NGDLSDQAVDYGAGIHLDDDLAGGFHSCDSEDDDGASHASSS---DWAPRPCIGPYTFVQRHLMM 234

  Fly   161 GRVPRQVIASIMPHFATGLAGDTDDSVLWDYLAHLLNEPKRRNKLASVNTFDDVISLVKKSQKII 225
            |..||.::..::|.  |....:.||..||..:.::|::|.:|.|...:||.||.:.|:::|:|||
Frog   235 GTDPRTILKDLLPD--TVAPSELDDMTLWQIVINILSDPPKRKKRKDINTIDDAVKLLQESKKII 297

  Fly   226 VLTGAGVSVSCGIPDFRSTNGIYARLAHDFPDLPDPQAMFDINYFKRDPRPFYKFAREIYPGEFQ 290
            ||||||||||||||||||.:|||||||.||||||:|||||||.||::|||||:|||:||:||:||
Frog   298 VLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPNPQAMFDIEYFRKDPRPFFKFAKEIFPGQFQ 362

  Fly   291 PSPCHRFIKMLETKGKLLRNYTQNIDTLERVAGIQRVIECHGSFSTASCTKCRFKCNADALRADI 355
            ||.|||||.||:.:.||||||||||||||:||||:::|:|||||:.|||..|::|.:.:|:|.||
Frog   363 PSLCHRFIAMLDKEEKLLRNYTQNIDTLEQVAGIEKIIQCHGSFAEASCLVCKYKVDCEAVREDI 427

  Fly   356 FAQRIPVCPQCQPNKEQSVDASVAVTEEELRQLVENGIMKPDIVFFGEGLPDEYHTVMATDKDVC 420
            |.|.:|.||:|.             ::|.|      .|||||||||||.||:::|..|..||:..
Frog   428 FNQIVPRCPRCS-------------SDEPL------AIMKPDIVFFGENLPEQFHRAMKYDKNEV 473

  Fly   421 DLLIVIGSSLKVRPVAHIPSSIPATVPQILINREQLHHLKFDVELLGDSDVIINQICHRLSDNDD 485
            ||||||||||||||||.||||||..|||||||||.|.||.||:|||||.|||||::|.||   |.
Frog   474 DLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDIELLGDCDVIINELCQRL---DG 535

  Fly   486 CWRQLCCDESVLTESKELMPPEHSNHHLHHHLLHHRHCSSESERQSQLDTDTQSIKSNSSADYIL 550
            .:.|||.:...|::..| .||     .:|...|    .|.|:...:.|:|.
Frog   536 KYSQLCTNSLKLSQITE-KPP-----RIHKGFL----TSPETVPSTDLNTG-------------- 576

  Fly   551 GSAGTCSDSGFESSTFSCGKRSTAAEAAAIERIKTDILVELNETTALS--CDRLGLEGPQTTVES 613
                       :|.......|.|..:.:|...:::  |.:..|.:.||  |....||     |..
Frog   577 -----------QSPALQSDLRGTDLQLSASNTMRS--LEKPEEASKLSHNCSEENLE-----VSK 623

  Fly   614 YRHLSIDSSKDSGIEQCDNEATPSYVRPSNLVQETKTVAPSLTPIPQQRGKRQTAAERLQPGTFY 678
            ..:..:.:.||....:.|.:           :...|.:....|        ::..::||....|.
Frog   624 EANTQLSNEKDQETAEKDTD-----------IDSAKDLESKYT--------KEQISKRLDSTQFL 669

  Fly   679 SHTNNYSYVFPGAQVFWDNDYS------------------------DDDDEEEERSHNRHSDLFG 719
            ....| .|:|.||:||.|:|..                        ::|.:.||..|.::.:
Frog   670 FLAPN-RYIFHGAEVFSDSDEDLTSSSCGTNSDSESLLSPSLHEPIEEDSDTEECFHAKYEN--- 730

  Fly   720 NVGHNYKDDDEDACDLNAVP 739
                  :.|.::..||...|
Frog   731 ------ETDTDNRADLEREP 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sirt1	NP_477351.1	DUF592	<202..228	CDD:282439	12/25 (48%)
Sirt1	NP_477351.1	SIRT1	222..476	CDD:238699	170/253 (67%)
sirt1	XP_012821550.2	SIRT1	294..529	CDD:238699	170/253 (67%)
sirt1	XP_012821550.2	MSCRAMM_ClfB	<593..753	CDD:411414	34/188 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	273	1.000	Domainoid score	I1762
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	415	1.000	Inparanoid score	I1793
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D512963at33208
OrthoFinder	1	1.000	-	-		FOG0000643
OrthoInspector	1	1.000	-	-		oto103653
Panther	1	1.100	-	-	LDO	PTHR48252
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R577
SonicParanoid	1	1.000	-	-		X3771
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.100