DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DnaJ-H and DNAJA3

DIOPT Version :9

Sequence 1:	NP_001260431.1	Gene:	DnaJ-H / 34707	FlyBaseID:	FBgn0032474	Length:	440	Species:	Drosophila melanogaster
Sequence 2:	NP_005138.3	Gene:	DNAJA3 / 9093	HGNCID:	11808	Length:	480	Species:	Homo sapiens

Alignment Length:	421	Identity:	126/421 - (29%)
Similarity:	182/421 - (43%)	Gaps:	97/421 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 YDVLKVAPDATDEEIKKNYRKLAKEFHPDKN---PDAGDKFKEISFAYEVLSDPEKRRIYDRYGL 68
            |.:|.|..:|:.:||||.|.:|||::|||.|   |.|.:||.:::.|||||||..||:.||.||.
Human    95 YQILGVPRNASQKEIKKAYYQLAKKYHPDTNKDDPKAKEKFSQLAEAYEVLSDEVKRKQYDAYGS 159

  Fly    69 KGLQEGAEGFS----------DASEFFAQWFPFDRVSSEGRGRRNGKVVVK------VELTLEEI 117
            .|...||.|..          |..|.|.:.|.....||.|    :.:.|..      :|||..:.
Human   160 AGFDPGASGSQHSYWKGGPTVDPEELFRKIFGEFSSSSFG----DFQTVFDQPQEYFMELTFNQA 220

  Fly   118 YVGGMKKKVEYNRQKLCSKCNGDG---GPKEAHESCETCGGAGRAAAFTFMGLSPF--DTTCPTC 177
             ..|:.|:...|....|.:|||.|   |.|..|  |..|||:|.....|    .||  .:||..|
Human   221 -AKGVNKEFTVNIMDTCERCNGKGNEPGTKVQH--CHYCGGSGMETINT----GPFVMRSTCRRC 278

  Fly   178 DGRGFTIRDDKKCSPCQGSGFVEQKMKRDLV-----VERGAPHMLKVPFANEGHQMRGGEFGDLI 237
            .|||..|  ...|..|:|:|..:|| ||.::     ||.|  ..:::|....          ::.
Human   279 GGRGSII--ISPCVVCRGAGQAKQK-KRVMIPVPAGVEDG--QTVRMPVGKR----------EIF 328

  Fly   238 VVISQMEHPIFQRRHANLYMRDLEINITEALCGYSHCFKHL-DGRNVCLRTYPGEVLQHNQIKMV 301
            :.....:.|:|:|..|::: .||.|:|.:||.|.:...:.| :..||   |.|.......:|:|
Human   329 ITFRVQKSPVFRRDGADIH-SDLFISIAQALLGGTARAQGLYETINV---TIPPGTQTDQKIRM- 388

  Fly   302 RGSGMPVFNKATDSGDLYMKFKVKFPDNDFATAPQLAMLEDLLPPRQPIVIPKNAEE-------- 358
            .|.|:|..| :...||.|:..|::.|..              |..||..:|...||:
Human   389 GGKGIPRIN-SYGYGDHYIHIKIRVPKR--------------LTSRQQSLILSYAEDETDVEGTV 438

  Fly   359 --VQMTD-----------YKPQPRQQEDEDG 376
              |.:|.           .|.:....|||:|
Human   439 NGVTLTSSGGSTMDSSAGSKARREAGEDEEG 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DnaJ-H	NP_001260431.1	DnaJ	1..363	CDD:223560	120/395 (30%)
		DnaJ	5..64	CDD:278647	29/59 (49%)
		DnaJ_C	106..329	CDD:199909	69/239 (29%)
		DnaJ_zf	134..197	CDD:199908	26/67 (39%)
DNAJA3	NP_005138.3	DnaJ	90..480	CDD:223560	126/421 (30%)
		DnaJ	93..155	CDD:278647	29/59 (49%)
		DnaJ_C	207..416	CDD:199909	68/250 (27%)
		DnaJ_zf	236..296	CDD:199908	26/67 (39%)
		CXXCXGXG motif	236..243		4/6 (67%)
		CXXCXGXG motif	253..260		4/6 (67%)
		CXXCXGXG motif	275..282		3/6 (50%)
		CXXCXGXG motif	289..296		3/6 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	443..471		6/27 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910