DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DnaJ-H and Dnajc21

DIOPT Version :9

Sequence 1:	NP_001260431.1	Gene:	DnaJ-H / 34707	FlyBaseID:	FBgn0032474	Length:	440	Species:	Drosophila melanogaster
Sequence 2:	NP_084322.2	Gene:	Dnajc21 / 78244	MGIID:	1925371	Length:	531	Species:	Mus musculus

Alignment Length:	436	Identity:	103/436 - (23%)
Similarity:	151/436 - (34%)	Gaps:	137/436 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 YDVLKVAPDATDEEIKKNYRKLAKEFHPDKNPD----AGDKFKEISFAYEVLSDPEKRRIYDRYG 67
            |:.|.|..||::||:||.|||||..:|||||.|    |.::||.|..||:|||||::|..||.:.
Mouse     5 YEALGVRRDASEEELKKAYRKLALRWHPDKNLDNAAEAAEQFKLIQAAYDVLSDPQERAWYDNHR 69

  Fly    68 LKGLQEGAEG-FSDASEFFAQWFPFDRVSSEGRGRRNGKVVVKVELTL---EEIYVGGMKKKVEY 128
            ...|:.|.:| :.|.|.....:|.....|..|...|....|.:|...|   ||:
Mouse    70 EALLKGGLDGEYQDDSLDLLHYFTVTCYSGYGDDERGFYAVYRVVFELIAKEEL----------- 123

  Fly   129 NRQKLCSKCNGDGGPKEAHESCETCGGAGRAAAFTFMGLSPFDTTC--------PTCDGRGFT-- 183
                   :|..:|..    |...|.|.:          .|.:||..        ..|..:.|:
Mouse   124 -------ECMSEGDV----EDFPTFGDS----------QSDYDTVVHPFYAHWQSFCTQKNFSWK 167

  Fly   184 -----------------------IRD----DKKCSPCQGSGFVEQKMK-----RDLVVERGAPHM 216
                                   |||    :|.....|...|:.::.|     |.||.|:.|..
Mouse   168 EEYDTRQASNRWEKRAMEKENKKIRDRARKEKNELVRQLVAFIRKRDKRVQAHRKLVEEQNAEK- 231

  Fly   217 LKVPFANEGHQMRGGEFGDLIVVISQMEHPIFQRRHANLY-------MRDLEINITEALCGYSHC 274
                 |.:..:||             .:..:.|.:.|..|       |.:||..:.|....|...
Mouse   232 -----ARKAEEMR-------------RQQKLKQAKLAEQYREQSWMTMANLEKELQEMEARYEKE 278

  Fly   275 FKHLDGRNVCLRTYPGEVLQHNQIKMVRGSGMPVFNKATDSGDLYMKFKVKFPDNDFATAPQLAM 339
            |.  ||.:      ..||........:.|..    ::..:..:||........|..|.|...:..
Mouse   279 FG--DGSD------ENEVEDQEPRNGLDGKD----SEEAEEAELYQDLYCPACDKSFKTEKAMKN 331

  Fly   340 LEDLLPPRQPIVIPKNAEEVQMTDYKPQPRQQEDEDGQSSHFEGVQ 385
            .|.....|:.:.:.|              :|.|:|:.|   |.|||
Mouse   332 HEKSKKHREMVALLK--------------QQLEEEEEQ---FSGVQ 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DnaJ-H	NP_001260431.1	DnaJ	1..363	CDD:223560	95/412 (23%)
		DnaJ	5..64	CDD:278647	32/60 (53%)
		DnaJ_C	106..329	CDD:199909	46/274 (17%)
		DnaJ_zf	134..197	CDD:199908	15/99 (15%)
Dnajc21	NP_084322.2	DnaJ	3..66	CDD:278647	32/60 (53%)
		DBINO	<181..243	CDD:290603	15/80 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	278..309		6/42 (14%)
		zf-C2H2_jaz	314..339	CDD:288983	4/24 (17%)
		C2H2 Zn finger	316..338	CDD:275371	4/21 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..480		11/51 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	507..531
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910