DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DnaJ-H and sec63

DIOPT Version :9

Sequence 1:	NP_001260431.1	Gene:	DnaJ-H / 34707	FlyBaseID:	FBgn0032474	Length:	440	Species:	Drosophila melanogaster
Sequence 2:	NP_595985.1	Gene:	sec63 / 2540961	PomBaseID:	SPBC36B7.03	Length:	611	Species:	Schizosaccharomyces pombe

Alignment Length:	462	Identity:	87/462 - (18%)
Similarity:	148/462 - (32%)	Gaps:	185/462 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LNL---YDVLKVAPDATDEEIKKNYRKLAKEFHPDK--------NPDAGDKFKEISFAYEVLSDP 57
            ||:   |::|.:|...:.::::::|::|:.:|||||        ..:....:.||:.||..|:|.
pombe    94 LNIWDPYEILGIAKGTSVDDVRRHYKRLSIKFHPDKVRNMVNTTREEVEKHYIEITNAYRALTDD 158

  Fly    58 EKRRIYDRYGL--------------KGLQEGAE-----GFSD----------------ASEFFA- 86
            :.|..|..||.              |.:.|...     ||..                .|..:.
pombe   159 KTRENYALYGTPDVPQHISVGIALPKWISESENSIYILGFYGLVFGIVLPYAVGKWWYGSRTYTR 223

  Fly    87 ---------QWFPFDRVSSEGRGRRNGKVVVKVELTLEEIYVGGMKKKVEYNRQKLCSKCNGDGG 142
                     :|||                .::..|||:|:.      .:..:.::|.|....:..
pombe   224 DHVHVDTVDEWFP----------------KMETSLTLDELL------SLFASSKELTSLVPNEKN 266

  Fly   143 PKE-------AHESCETCGGAGRAAAFTFMGLSPFDTTCPTCDGRGFTIRDDKKCSPCQGSGF-- 198
            |||       .|.:.:......     |...||..|...            :...|.....||
pombe   267 PKEYILKLLFDHLNRKKTNNFN-----THQILSQSDVVL------------NALLSVATAFGFAN 314

  Fly   199 -VEQKMKRDLVVERGAPHMLKVPFANEGHQMRGGEFGDLIVVISQMEHPIFQRRHANLYMRDLEI 262
             |:..:|....:.:..|  |..||                        |:.|..|  |.|.|:
pombe   315 PVDNVLKLWQHIVQAIP--LDAPF------------------------PLLQLPH--LLMEDV-- 349

  Fly   263 NITEALCGYSHCFKHLDGRNVC----------------LRTYPGEVLQHNQIKMVR--GSGMPVF 309
                         |:|..||:.                |..|     ..||:|.:|  .:|:|..
pombe   350 -------------KNLSIRNISSIPQFLSLSEEQTKDYLPNY-----SKNQLKEMREIANGIPRI 396

  Fly   310 NKATDSGDLYMKFKVKFPDNDFATAPQLA-MLEDLLPPRQPIVIPKNAEEVQMTDYKPQPRQQED 373
            :        .:..||...|:::.|...:| ::.||.......|:|    ||. ||......::::
pombe   397 S--------VVAAKVLVDDDEYITVGAIANLILDLKCSYGTEVVP----EVS-TDGTETATKKDE 448

  Fly   374 EDGQSSH 380
            ||.:..|
pombe   449 EDAEKYH 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DnaJ-H	NP_001260431.1	DnaJ	1..363	CDD:223560	82/443 (19%)
		DnaJ	5..64	CDD:278647	18/69 (26%)
		DnaJ_C	106..329	CDD:199909	43/250 (17%)
		DnaJ_zf	134..197	CDD:199908	10/69 (14%)
sec63	NP_595985.1	SEC63	1..611	CDD:227694	87/462 (19%)
		DnaJ	98..164	CDD:278647	17/65 (26%)
		Sec63	229..541	CDD:214946	60/327 (18%)
		Nro1	<543..>599	CDD:289519
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910