DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kmg and ZNF184

DIOPT Version :9

Sequence 1:	NP_609604.1	Gene:	kmg / 34706	FlyBaseID:	FBgn0032473	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	NP_001305820.1	Gene:	ZNF184 / 7738	HGNCID:	12975	Length:	751	Species:	Homo sapiens

Alignment Length:	653	Identity:	122/653 - (18%)
Similarity:	207/653 - (31%)	Gaps:	196/653 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 EQQLEQYKANNFMFPLSMAGFVSADSAP---PGDLAKE-----NMENSLPDGNPC---------- 100
            |..||:.:||....|..:.  |:..:.|   .|.:..|     |:.::|....|.
Human   147 EGSLERQQANQQTLPKEIK--VTEKTIPSWEKGPVNNEFGKSVNVSSNLVTQEPSPEETSTKRSI 209

  Fly   101 --NNNNDDELPQCKIRRNYSCNQCAFFTQNPRSHLSHLRDVHGERIVINECKLCLYASRHFQKLV 163
              |:|...:...||      ||:|........:.:.|.|...||:..  :|..|..|....:.|:
Human   210 KQNSNPVKKEKSCK------CNECGKAFSYCSALIRHQRTHTGEKPY--KCNECEKAFSRSENLI 266

  Fly   164 RHMKMVHG-----CSDDG-GAVQG----------SGAQPR-----GKRNLSRE--VRKRRLEESI 205
            .|.::..|     |...| |.::|          :|.:|.     ||....|.  |:.:|:.
Human   267 NHQRIHTGDKPYKCDQCGKGFIEGPSLTQHQRIHTGEKPYKCDECGKAFSQRTHLVQHQRIH--- 328

  Fly   206 EGQGATGQ----CLDLSVLRMIQNGPPLEQLKVELQQQEMQLLASVQAYNRQQEMLQLQQI---- 262
                 ||:    |.:.. ....|.|..:|..|:...::..:.....:.:.|...:.|.|:|
Human   329 -----TGEKPYTCNECG-KAFSQRGHFMEHQKIHTGEKPFKCDECDKTFTRSTHLTQHQKIHTGE 387

  Fly   263 ----------VESHDNIFSMAYEFQTKLMPPKQAESLKLEQQNSS-------------SDSEETA 304
                      ..:..:.|...:...|...|.:..|..|...|:|:             .|..|..
Human   388 KTYKCNECGKAFNGPSTFIRHHMIHTGEKPYECNECGKAFSQHSNLTQHQKTHTGEKPYDCAECG 452

  Fly   305 KSPS-----PDTRELVSGKEQFQCQKCSYSTPIRARFKKHVKYHSMPL-IKCSSCDFHTPYKWNL 363
            ||.|     ....::.:|::.::|.:|..:....:...:|.:.|:... .:||.|.....|..||
Human   453 KSFSYWSSLAQHLKIHTGEKPYKCNECGKAFSYCSSLTQHRRIHTREKPFECSECGKAFSYLSNL 517

  Fly   364 DRHTKNHGANGHFKCSCCDFSTDIKQSLTIHESNH--HVPMPVHQMGNRSRDEAEDLVDQQSSGS 426
            ::|.|.|.....::|..|..:.....||..||..|  ..|...|:.|
Human   518 NQHQKTHTQEKAYECKECGKAFIRSSSLAKHERIHTGEKPYQCHECG------------------ 564

  Fly   427 RKPETFKNGGATVASTESLLPRTSGIVCSHCQKRVGNAMQLINHLQVCTLALHNTTQLQASINAE 491
               :||..|.:.: ....:........|:.|.:.....:.|..|.::.|.|
Human   565 ---KTFSYGSSLI-QHRKIHTGERPYKCNECGRAFNQNIHLTQHKRIHTGA-------------- 611

  Fly   492 VDLHDEDFPNAPTDLSYCGVETAPGYGEVTEVLPEEPEDLAPLKKVFKCPHCSFWAATASRFHVH 556
                      .|.:.:.||                         |.|:  |||..|.       |
Human   612 ----------KPYECAECG-------------------------KAFR--HCSSLAQ-------H 632

  Fly   557 IVGHLNRKPFECSLCAYRSNWRWDITKHIRL-------------KALRDRSHNQAQVLMNDETGR 608
            ...|...||::|:.|....:....:|:|.|:             ||....:|....  .|..||.
Human   633 QKTHTEEKPYQCNKCEKTFSQSSHLTQHQRIHTGEKPYKCNECDKAFSRSTHLTEH--QNTHTGE 695

  Fly   609 RNY 611
            :.|
Human   696 KPY 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kmg	NP_609604.1	C2H2 Zn finger	540..560	CDD:275370	5/19 (26%)
kmg	NP_609604.1	C2H2 Zn finger	568..586	CDD:275370	4/17 (24%)
ZNF184	NP_001305820.1	KRAB	28..88	CDD:214630
		KRAB	28..67	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	191..212		2/20 (10%)
		C2H2 Zn finger	224..244	CDD:275368	5/19 (26%)
		zf-H2C2_2	236..261	CDD:290200	7/26 (27%)
		COG5048	<248..409	CDD:227381	29/171 (17%)
		C2H2 Zn finger	252..272	CDD:275368	5/19 (26%)
		zf-H2C2_2	264..287	CDD:290200	5/22 (23%)
		C2H2 Zn finger	280..300	CDD:275368	4/19 (21%)
		zf-H2C2_2	292..317	CDD:290200	4/24 (17%)
		C2H2 Zn finger	308..328	CDD:275368	5/19 (26%)
		zf-H2C2_2	320..345	CDD:290200	5/33 (15%)
		C2H2 Zn finger	336..356	CDD:275368	5/20 (25%)
		zf-H2C2_2	348..373	CDD:290200	2/24 (8%)
		COG5048	360..736	CDD:227381	74/421 (18%)
		C2H2 Zn finger	364..384	CDD:275368	3/19 (16%)
		zf-H2C2_2	376..400	CDD:290200	3/23 (13%)
		C2H2 Zn finger	392..412	CDD:275368	1/19 (5%)
		zf-C2H2	418..440	CDD:278523	4/21 (19%)
		C2H2 Zn finger	420..440	CDD:275368	4/19 (21%)
		zf-H2C2_2	432..457	CDD:290200	4/24 (17%)
		C2H2 Zn finger	448..468	CDD:275368	4/19 (21%)
		zf-H2C2_2	460..485	CDD:290200	3/24 (13%)
		C2H2 Zn finger	476..496	CDD:275368	3/19 (16%)
		zf-H2C2_2	488..513	CDD:290200	5/24 (21%)
		C2H2 Zn finger	504..524	CDD:275368	8/19 (42%)
		zf-H2C2_2	516..541	CDD:290200	7/24 (29%)
		C2H2 Zn finger	532..552	CDD:275368	6/19 (32%)
		zf-H2C2_2	544..569	CDD:290200	10/45 (22%)
		C2H2 Zn finger	560..580	CDD:275368	5/41 (12%)
		zf-H2C2_2	572..597	CDD:290200	2/25 (8%)
		C2H2 Zn finger	588..608	CDD:275368	4/19 (21%)
		zf-H2C2_2	600..625	CDD:290200	9/75 (12%)
		C2H2 Zn finger	616..636	CDD:275368	9/53 (17%)
		zf-H2C2_2	628..653	CDD:290200	7/31 (23%)
		C2H2 Zn finger	644..664	CDD:275368	5/19 (26%)
		zf-H2C2_2	656..681	CDD:290200	5/24 (21%)
		C2H2 Zn finger	672..692	CDD:275368	4/21 (19%)
		zf-H2C2_2	684..709	CDD:290200	5/17 (29%)
		C2H2 Zn finger	700..720	CDD:275368
		C2H2 Zn finger	728..748	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000