DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kmg and ZNF335

DIOPT Version :9

Sequence 1:NP_609604.1 Gene:kmg / 34706 FlyBaseID:FBgn0032473 Length:747 Species:Drosophila melanogaster
Sequence 2:NP_071378.1 Gene:ZNF335 / 63925 HGNCID:15807 Length:1342 Species:Homo sapiens


Alignment Length:728 Identity:135/728 - (18%)
Similarity:237/728 - (32%) Gaps:238/728 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   142 ERIVINE--CKLCLYASRHFQKLVRHMKMVHGCSDDGGAVQGSGAQPRGKRNLSREVRKRRLEES 204
            |.:|:.:  ||:|.|.|.....|:|||:..|      .....:.|...||:.     |.|:...|
Human   238 EVVVVQQFKCKMCQYRSSTKATLLRHMRERH------FRPVAAAAAAAGKKG-----RLRKWSTS 291

  Fly   205 IEGQGATG-------QCLDLSVLRMIQNGPPLEQLKVELQQQEMQLLASVQAYNRQQ-------- 254
            .:.|...|       ..:|...:..::........:.|.:.::::|.....:..|.:        
Human   292 TKSQEEEGPEEEDDDDIVDAGAIDDLEEDSDYNPAEDEPRGRQLRLQRPTPSTPRPRRRPGRPRK 356

  Fly   255 ----EMLQLQQIVESHDNIFSMAYEFQTKLMPPKQAES--------------LKLEQQNSSSDSE 301
                |:..|...||....:.|.:.:...:...|:...|              ..:|...|.||:|
Human   357 LPRLEISDLPDGVEGEPLVSSQSGQSPPEPQDPEAPSSSGPGHLVAMGKVSRTPVEAGVSQSDAE 421

  Fly   302 ETAKSPSPDTRELVS-----------GKE--------------QFQCQKCSYSTPIRARFKKH-- 339
            ..|.| .||..:.:.           ||:              .|.|:.|.      :||..|  
Human   422 NAAPS-CPDEHDTLPRRRGRPSRRFLGKKYRKYYYKSPKPLLRPFLCRICG------SRFLSHED 479

  Fly   340 VKYH-------SMPLIKCSSCDFHTPYKW-NLDRHTKNHGANGHFKCSCCDFSTDIKQSLTIHES 396
            :::|       ...|.||..|.:.: .:| :|..|..||..:..:||..|.:::..::.:..|.:
Human   480 LRFHVNSHEAGDPQLFKCLQCSYRS-RRWSSLKEHMFNHVGSKPYKCDECSYTSVYRKDVIRHAA 543

  Fly   397 NHHVPMPVHQMGNRSRDEAEDLVDQQSSGSRKPETFKNGGATVASTESLLPRTSGIVCSHCQKRV 461
            .|            |||.           .::|:.              .|:.|...|..|.:..
Human   544 VH------------SRDR-----------KKRPDP--------------TPKLSSFPCPVCGRVY 571

  Fly   462 GNAMQLINHLQVCTLALHNTTQLQASINAEVDLHDEDFPNAPTDLSYCGVETAPGYGEVTEVLPE 526
            ....:|..|::.     |:|.:                   |.....||......|.....:|..
Human   572 PMQKRLTQHMKT-----HSTEK-------------------PHMCDKCGKSFKKRYTFKMHLLTH 612

  Fly   527 EPEDLAPLKKVFKCPHCSFWAATASRFHVHIVGHLNRKPFECSLCAYRSNWRWD-ITKHIRLK-- 588
            ..   |...:.|||..|.|..........|.:.|::.|||:||.|.||: :|.| :..|:.:|  
Human   613 IQ---AVANRRFKCEFCEFVCEDKKALLNHQLSHVSDKPFKCSFCPYRT-FREDFLLSHVAVKHT 673

  Fly   589 ------------ALRDRSHNQAQVLMN-----DETGRRN----YAKYNQYLTMMKVSAEQLADSK 632
                        :.|.:.:.:..|...     :|.|||:    .::...:.::.::  |:|....
Human   674 GAKPFACEYCHFSTRHKKNLRLHVRCRHASSFEEWGRRHPEEPPSRRRPFFSLQQI--EELKQQH 736

  Fly   633 GMRTGEMIVMPPEKLDDHHPMETEEIIEMVDSAHSTSALDLRKPRDDQTEDLAGNSDELPQEGAK 697
            ....|     ||.  ....|.|.........|:.:.|.|         ..|..|.:..:.|:||:
Human   737 SAAPG-----PPP--SSPGPPEIPPEATTFQSSEAPSLL---------CSDTLGGATIIYQQGAE 785

  Fly   698 ------TEPNLEPLSFKSLNSS----------QV-----------------MPKPKGS-----PM 724
                  |:..|:.|    ||.|          ||                 .|.|:|:     .:
Human   786 ESTAMATQTALDLL----LNMSAQRELGGTALQVAVVKSEDVEAGLASPGGQPSPEGATPQVVTL 846

  Fly   725 NLTKTDGGQSDET 737
            ::.:..||.:.|:
Human   847 HVAEPGGGAAAES 859

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kmgNP_609604.1 C2H2 Zn finger 540..560 CDD:275370 4/19 (21%)
C2H2 Zn finger 568..586 CDD:275370 8/18 (44%)
ZNF335NP_071378.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..102
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 201..228
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 274..442 28/173 (16%)
C2H2 Zn finger 467..487 CDD:275368 6/25 (24%)
C2H2 Zn finger 497..517 CDD:275368 5/20 (25%)
zf-H2C2_2 509..534 CDD:290200 7/24 (29%)
C2H2 Zn finger 529..545 CDD:275370 1/15 (7%)
C2H2 Zn finger 564..584 CDD:275368 4/24 (17%)
zf-H2C2_2 577..600 CDD:290200 7/46 (15%)
zf-C2H2 590..612 CDD:278523 4/21 (19%)
C2H2 Zn finger 592..612 CDD:275368 4/19 (21%)
C2H2 Zn finger 623..643 CDD:275368 4/19 (21%)
C2H2 Zn finger 651..672 CDD:275368 8/21 (38%)
C2H2 Zn finger 680..699 CDD:275368 2/18 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 732..763 7/37 (19%)
PRK04654 <795..911 CDD:135173 13/69 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 964..1013
C2H2 Zn finger 1021..1041 CDD:275368
Involved in the interaction with CCAR2. /evidence=ECO:0000269|PubMed:19131338 1041..1342
C2H2 Zn finger 1049..1069 CDD:275368
zf-H2C2_5 1075..1097 CDD:290620
C2H2 Zn finger 1077..1097 CDD:275368
zf-H2C2_2 1089..1114 CDD:290200
C2H2 Zn finger 1105..1126 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165144318
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24403
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.030

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