DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kmg and ZNF462

DIOPT Version :9

Sequence 1:	NP_609604.1	Gene:	kmg / 34706	FlyBaseID:	FBgn0032473	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	XP_006717272.1	Gene:	ZNF462 / 58499	HGNCID:	21684	Length:	2567	Species:	Homo sapiens

Alignment Length:	891	Identity:	160/891 - (17%)
Similarity:	282/891 - (31%)	Gaps:	345/891 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 DELPQC--KIRR---NYSCNQCAFFTQNPRSHLSHLRDVHGERIVINECKLCLYASRH---FQKL 162
            |:.||.  ::||   ...|:.|:|.:.:.:..:||                  |..||   |.|.
Human  1751 DDSPQLSEELRRAVEKKKCSLCSFQSFSKKGIVSH------------------YMKRHPGVFPKK 1797

  Fly   163 VRHMKMVHGCSDDGGAVQGSGAQPRGKRNLSREVRKRRLEES-IEGQGATGQCLDLSVLR----- 221
            ....|:       ||......|....|..|..|..:...|:: :||:....:.|....::
Human  1798 QHASKL-------GGYFTAVYADEHEKPTLMEEEERGNFEKAEVEGEAQEIEWLPFRCIKCFKLS 1855

  Fly   222 ------------------------MIQNGPPLE------------------------------QL 232
                                    ::.|||.|:                              |.
Human  1856 FSTAELLCMHYTDHHSRDLKRDFIILGNGPRLQNSTYQCKHCDSKLQSTAELTSHLNIHNEEFQK 1920

  Fly   233 KVELQQQEMQLLASVQAY--------NRQQEMLQLQQI----------------VESHDNIFSMA 273
            :.:.|::..||| |.|.|        .:::....|:::                ||.|..:.::.
Human  1921 RAKRQERRKQLL-SKQKYADGAFADFKQERPFGHLEEVPKIKERKVVGYKCKFCVEVHPTLRAIC 1984

  Fly   274 YEFQTKLM---PPKQAESLKLEQQNSSS---DSEETAKSPS-------------------PDTR- 312
            ...:..:.   .|..:.::|.|..:.:.   |..|.||..|                   .:||
Human  1985 NHLRKHVQYGNVPAVSAAVKQEADDPAHLFLDGLEAAKDASGALVGRVDGEHCLLDGMLEDETRP 2049

  Fly   313 ----------------------------ELVSGKEQFQCQKCSYSTPIRARFKKHVKY---HSMP 346
                                        .:.:.::::.||.||:.:..|....:|::.   |..|
Human  2050 GGYHCSQCDRVLMSMQGLRSHERSHLALAMFTREDKYSCQYCSFVSAFRHNLDRHMQTHHGHHKP 2114

  Fly   347 LIKCSSCDFHTPYKWNLDRH-TKNHGANGHFKCSCCDFST----DIKQ-SLTIHESNHHVPMP-- 403
             .:|..|.|.:.|...|..| .|.|.....:|||.|.|||    .:|: ||.:|.....:|.|
Human  2115 -FRCKLCSFKSSYNSRLKTHILKAHAGEHAYKCSWCSFSTMTISQLKEHSLKVHGKALTLPRPRI 2178

  Fly   404 VHQMGNRSRDE------AEDLVDQQSSGSRKPETFKNGGATVASTESLLPRTSGIVCSHCQKRVG 462
            |..:.:.|...      ||::.|...|...:|.
Human  2179 VSLLSSHSHHSSQKATPAEEVEDSNDSSYSEPP-------------------------------- 2211

  Fly   463 NAMQLINHLQVCTLALHNTTQLQASIN---------AEVDLHDEDFPNAPTDLSYCGVETAPGYG 518
            :..|.:||.|...||.:|:......::         .|..||.|          :|  |.:.||
Human  2212 DVQQQLNHYQSAALARNNSRVSPVPLSGAAAGTEQKTEAVLHCE----------FC--EFSSGY- 2263

  Fly   519 EVTEVLPEEPEDLAPLKKVFKCPHCSFWAATASRFHVHI-VGHL-----NRKPFECSLCAYRSNW 577
              .:.:.....|....||:|||..|||:....|.|.:|: .||.     ..|...|.||.|.:.:
Human  2264 --IQSIRRHYRDKHGGKKLFKCKDCSFYTGFKSAFTMHVEAGHSAVPEEGPKDLRCPLCLYHTKY 2326

  Fly   578 RWDITKHIRLKALRDRSHNQAQVL---------------------------MNDETGRRNYAKYN 615
            :.::..||.|       |.:.:|:                           .:||:.:::..|:|
Human  2327 KRNMIDHIVL-------HREERVVPIEVCRSKLSKYLQGVVFRCDKCTFTCSSDESLQQHIEKHN 2384

  Fly   616 QYLTMMKVSAEQLADSKGMRTGEMIVMPPEKLDDHHP----------METEEIIEMVDSAHSTSA 670
            :    :|....||...:...|.|:    ...|.|.|.          :..:::.:|.:...|:|:
Human  2385 E----LKPYKCQLCYYETKHTEEL----DSHLRDEHKVSRNFELVGRVNLDQLEQMKEKMESSSS 2441

  Fly   671 LDLRKPRDDQTEDLAGNSDE-----LPQEGA--KTEPNLEPLSF--------------------- 707
            .|     :|:.|::...:::     ....||  .||... |..|
Human  2442 DD-----EDKEEEMNSKAEDRELMRFSDHGAALNTEKRF-PCEFCGRAFSQGSEWERHVLRHGMA 2500

  Fly   708 ----KSLNSSQVMPKP-KGSPMNLTKTDGGQSDETTSADES--NES 746
                |.::..::.||. ..:.:.:...:..:.||....|.|  ||:
Human  2501 LNDTKQVSREEIHPKEIMENSVKMPSIEEKEDDEAIGIDFSLKNET 2546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kmg	NP_609604.1	C2H2 Zn finger	540..560	CDD:275370	7/20 (35%)
kmg	NP_609604.1	C2H2 Zn finger	568..586	CDD:275370	5/17 (29%)
ZNF462	XP_006717272.1	C2H2 Zn finger	2054..2074	CDD:275368	0/19 (0%)
		C2H2 Zn finger	2088..2108	CDD:275368	6/19 (32%)
		C2H2 Zn finger	2117..2138	CDD:275368	7/20 (35%)
		zf-H2C2_5	2144..2169	CDD:316431	11/24 (46%)
		C2H2 Zn finger	2146..2167	CDD:275368	9/20 (45%)
		C2H2 Zn finger	2317..2337	CDD:275368	7/26 (27%)
		C2H2 Zn finger	2363..2383	CDD:275368	2/19 (11%)
		C2H2 Zn finger	2391..2412	CDD:275368	6/24 (25%)
		C2H2 Zn finger	2477..2497	CDD:275368	1/19 (5%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC9A
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40680
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.960