DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kmg and znf513a

DIOPT Version :9

Sequence 1:	NP_609604.1	Gene:	kmg / 34706	FlyBaseID:	FBgn0032473	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	NP_001296396.1	Gene:	znf513a / 568216	ZFINID:	ZDB-GENE-030131-9895	Length:	548	Species:	Danio rerio

Alignment Length:	669	Identity:	126/669 - (18%)
Similarity:	192/669 - (28%)	Gaps:	274/669 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 EGGAGAVLPMSQSVQPLIGQDF-LEQQLEQYKANN---------FMFPLSMAGFVSADSAPPGD- 84
            |.|.|.|.|.:.:.:    .|| |.|:||....:|         |...:|:.||      |.||
Zfish    17 EDGVGTVRPTNLTFE----SDFLLGQELEFSDPDNDQKIIGLEKFSADISLPGF------PLGDE 71

  Fly    85 ----LAKENMENSLPDGNPCNNNNDDELPQCKIRRNYSCNQCAFFTQNPRSHLSHLRDVHG---- 141
                .::.:||:...|.....:..::.:.:.......||..|....::|   |....|:.|
Zfish    72 ENSPFSRLSMESDADDLRATESEREERVSESAFPSYLSCRGCGQLLEDP---LGPGMDLVGPYCM 133

  Fly   142 -------ERIV-----------------------------INECKLCLYASRHFQKLVRHMKMVH 170
                   |.||                             ::.|.||.:.||:...:.|||| .|
Zfish   134 RCCKGNVEGIVDRKLCSGLGLQAESRGGGNEGTGEDGSLKLHSCTLCGFTSRYTNHVKRHMK-TH 197

  Fly   171 GCSDDGGAVQGSGAQPRG----------KRNLSREVRKRRLEESIEGQGATGQCLDLSVLRMIQN 225
                       :|.:|.|          ..||.|.:|....|:..:....|..|..|..|:..|.
Zfish   198 -----------NGEKPYGCPLCSYASAQLVNLQRHLRIHTGEKPYKCNTCTFACSSLGNLKRHQR 251

  Fly   226 -----GP------PLE----------QLKVELQQQEMQLLASVQAYNRQQEMLQLQQIVESHDNI 269
                 ||      |:.          |.:.|......::..:|::..|..         ...|..
Zfish   252 MHATIGPGQSVTQPVSGNGLNHSTAAQKEKEAVPAPTEVAGAVRSVTRPH---------MGRDGN 307

  Fly   270 FSMAYEFQTKLMPPKQAESLKLEQQNSSS--DSEETAKSPS-------PDTRELV-------SGK 318
            :...:            :.|:|.||.|:.  .|.:.|..|:       |.|..|.       .|.
Zfish   308 YLQTF------------DGLRLAQQTSTGVLQSGQAASQPAALPPMFFPFTCRLCGMALDDEDGS 360

  Fly   319 EQFQCQKCSYSTPIRARFKKHVKYHSMP------LIKCSSCDFHTPYKWNLDRHTKNHGANGHFK 377
            ....|.||:.....:       ..|..|      :..|::|.|.|.|..:|.||.|.|.....:|
Zfish   361 SAQICAKCTLEMLTK-------DTHGCPAERGDKVYTCAACPFLTHYPNHLARHMKTHSGEKPYK 418

  Fly   378 CSCCDFSTDIKQSLTIHESN---HHVPMPVHQMGNRSRDEAEDLVDQQSSGSRKPETFKNGGATV 439
            |..||::       :.|..|   ||   .||.                   ..||  :|
Zfish   419 CPQCDYA-------SAHFDNLKRHH---RVHT-------------------GEKP--YK------ 446

  Fly   440 ASTESLLPRTSGIVCSHCQKRVGNAMQLINHLQVCTLALHNTTQLQASINAEVDLHDEDFPNAPT 504
                          |..|....||...|..|.:|.:.|
Zfish   447 --------------CHLCDYACGNLANLKRHQRVHSGA--------------------------- 470

  Fly   505 DLSYCGVETAPGYGEVTEVLPEEPEDLAPLKKVFKCPHCSFWAATASRFHVHIVGHLNRKPFECS 569
                                           |.|:|..|::....:.....|::.|...||.:|.
Zfish   471 -------------------------------KPFQCAICNYSCNQSMNLKRHMLRHTGEKPHKCQ 504

  Fly   570 LCAYRSNWRWDITKHIRLK 588
            .|.|.:. .||..|..:.|
Zfish   505 ECGYTTG-HWDNYKRHQKK 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kmg	NP_609604.1	C2H2 Zn finger	540..560	CDD:275370	3/19 (16%)
kmg	NP_609604.1	C2H2 Zn finger	568..586	CDD:275370	6/17 (35%)
znf513a	NP_001296396.1	C2H2 Zn finger	177..197	CDD:275368	9/20 (45%)
		zf-H2C2_2	189..214	CDD:290200	8/36 (22%)
		COG5048	201..>503	CDD:227381	76/438 (17%)
		C2H2 Zn finger	205..225	CDD:275368	4/19 (21%)
		zf-H2C2_2	217..242	CDD:290200	7/24 (29%)
		C2H2 Zn finger	233..253	CDD:275368	5/19 (26%)
		C2H2 Zn finger	391..411	CDD:275368	9/19 (47%)
		zf-H2C2_2	403..428	CDD:290200	9/31 (29%)
		C2H2 Zn finger	419..439	CDD:275368	7/29 (24%)
		zf-H2C2_2	431..454	CDD:290200	10/66 (15%)
		C2H2 Zn finger	447..467	CDD:275368	6/19 (32%)
		zf-H2C2_2	459..484	CDD:290200	8/82 (10%)
		C2H2 Zn finger	475..495	CDD:275368	3/19 (16%)
		zf-H2C2_2	487..510	CDD:290200	7/22 (32%)
		C2H2 Zn finger	503..523	CDD:275368	7/21 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100