DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kmg and rest

DIOPT Version :9

Sequence 1:	NP_609604.1	Gene:	kmg / 34706	FlyBaseID:	FBgn0032473	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	NP_001340795.1	Gene:	rest / 564772	ZFINID:	ZDB-GENE-080415-1	Length:	854	Species:	Danio rerio

Alignment Length:	580	Identity:	113/580 - (19%)
Similarity:	208/580 - (35%)	Gaps:	154/580 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   223 IQNGPPLEQLK-VELQQQEMQLLASVQAYNRQQEMLQLQQIVESHDN----IFSMAYEFQ----- 277
            ||..|.||::: |.:.:...|..::..|.:.:|:...| .|:||...    .|....::|
Zfish    91 IQPEPVLEEIEIVRVGRPPNQTESTENAASAEQKRTTL-AILESSKKKKKPFFCKPCQYQGENEQ 154

  Fly   278 -----------TKLMPPKQAESLKLEQQNSSSDSEETAKSPSPDTRELVSGKEQFQCQKCSYSTP 331
                       .|::.....:|    .::.|:|:......|:.::.| .:.|...:|::|.|:|.
Zfish   155 EFIVHIRTHGAKKMLVVNGGDS----DEDLSADAGPQTSVPNAESAE-SNSKGVIRCERCGYNTN 214

  Fly   332 IRARFKKHVKYHS-----MPLIKCSSCDFHTPYKWNLDRHTKNHGANGHFKCSCCDFSTDIKQSL 391
            ....:..|:|:|:     ..:.||:.|.:.|..:::..:|.:||..:..|.||.|.:.:|.|.:.
Zfish   215 RFDHYMAHLKHHTKEGEDQRVFKCTICAYTTISQYHWKKHLRNHFPSKLFTCSQCSYFSDRKNNY 279

  Fly   392 TIHESNHHVPMPVHQMGNRSRDEAEDLVDQQSSGSRKPETFKNGGATVASTESLLPRTSGIVCSH 456
            ..|...|                         :|.|.                       ..|.:
Zfish   280 IQHIRTH-------------------------TGERP-----------------------FQCIY 296

  Fly   457 CQKRVGNAMQLINHLQVCT----LALHNTTQLQASINAEVDLHDEDFPNAPTDLSYCGVETAPGY 517
            |:........|..|::..:    ....|.:.|.|: ..||..|.....|.|..||
Zfish   297 CEYSSSQKTHLTRHMRTHSGERPFKCDNCSYLAAN-QHEVTRHARQVHNGPKPLS---------- 350

  Fly   518 GEVTEVLPEEPEDLAPLKKVFKCPHCSFWAATASRFHVHIVGHLNRKPFECSLCAYRSNWRWDIT 582
                                  ||:|.:..|..|.|..|:..|:|.:.|.|.:|.|.::.:.::.
Zfish   351 ----------------------CPYCQYKTADRSNFKKHVELHVNPRQFLCPVCKYAASKKCNLQ 393

  Fly   583 KHIRLK--ALRDRSHNQAQVLMNDETGRRNYAKYNQYLTMMKVSAEQLADSKGMRTGEMIVMPPE 645
            .||:.:  ..:|.|.:.::|.:..:....:.|..|      |::|||   :|.|.  |:....|.
Zfish   394 YHIKSRHPGCKDISMDVSKVRLRVKRSDGDDASPN------KLTAEQ---AKIME--ELEDAGPI 447

  Fly   646 KLDDHHPMETEEIIEMVDSA-------------HSTSALDLRKPRDDQTEDLAGNSDELPQEGAK 697
            .|....|.:...::|...|:             :...:|...:|::...:.|.|.:.....|..:
Zfish   448 NLSIKKPSKLNAVVETEKSSKKNMDGKANQPQPNEKKSLSKNEPKEKTAKKLKGKTAVKDTEETQ 512

  Fly   698 TE----------PNLEPLSFKSLNSSQVMPKP-KGSPMNLTKTDGGQSDETTSADESNES 746
            ||          ...|..:.|:|.|.|...|| |.|.:.....|..|:..|...:|:.|:
Zfish   513 TEDTRVNNKKETKKAEKSAEKALKSRQKKEKPVKDSSVQQQSDDCEQTQHTPQQNETQEN 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kmg	NP_609604.1	C2H2 Zn finger	540..560	CDD:275370	7/19 (37%)
kmg	NP_609604.1	C2H2 Zn finger	568..586	CDD:275370	4/17 (24%)
rest	NP_001340795.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	172..199		5/31 (16%)
		C2H2 Zn finger	238..258	CDD:275368	4/19 (21%)
		C2H2 Zn finger	266..286	CDD:275368	6/19 (32%)
		zf-H2C2_2	278..303	CDD:316026	6/72 (8%)
		zf-C2H2_2	293..>367	CDD:315435	20/106 (19%)
		C2H2 Zn finger	294..314	CDD:275368	4/19 (21%)
		zf-H2C2_2	306..327	CDD:316026	3/20 (15%)
		C2H2 Zn finger	326..343	CDD:275370	5/17 (29%)
		C2H2 Zn finger	351..371	CDD:275368	7/19 (37%)
		C2H2 Zn finger	379..397	CDD:275368	4/17 (24%)
		MIP-T3	453..>769	CDD:313469	24/120 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000