DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kmg and ZNF407

DIOPT Version :9

Sequence 1:	NP_609604.1	Gene:	kmg / 34706	FlyBaseID:	FBgn0032473	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	NP_001371404.1	Gene:	ZNF407 / 55628	HGNCID:	19904	Length:	2248	Species:	Homo sapiens

Alignment Length:	799	Identity:	162/799 - (20%)
Similarity:	260/799 - (32%)	Gaps:	258/799 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 GNPCNNNNDDEL--PQCKIRR-NYSCNQCAFFTQNPRSHLSHLR-DVHGERIVINECKLCLYASR 157
            |....|..|.|:  .:|..|. .:.|..|.|.:.:.|....||. :.|.:...:..|:.|.:.|.
Human   534 GQVATNRTDLEIHVKRCHAREMKFYCRTCDFSSMSRRDLDEHLHSNQHQQTASVLSCQCCSFISL 598

  Fly   158 HFQKLVRHMKMVHG----CSDDGGAVQGSGAQPRGKRNLSREVRKRRLEESIEGQGATGQCLDLS 218
            ....|..|||..|.    |:            |.....||        |:.:|...||.:.::
Human   599 DEINLRDHMKEKHNMHFLCT------------PCNLFFLS--------EKDVEEHKATEKHIN-- 641

  Fly   219 VLRMIQNGPPLEQLKVELQQQEMQLLASVQAYNRQQEMLQLQQIVESHDNIFSMAYEFQTKLMPP 283
                                                .::|.:.:..|:.::.     .||..:..
Human   642 ------------------------------------SLVQPKTLQSSNSDLV-----LQTLPLST 665

  Fly   284 KQAESLKLEQQNSSSDS-EETAKSPSPDTREL-VSGKEQFQCQKCSYSTPIRARFKKHVK----- 341
            .::|:.|....:|...| ||..||......|: .|.|.||||:||.|.|.......:|:|
Human   666 LESENAKESMDDSGKASQEEPLKSRVSHGNEVRHSSKPQFQCKKCFYKTRSSTVLTRHIKLRHGQ 730

  Fly   342 -YHSMPLIKCSSCDFHTPYKWNLDRH----------TKNHGANGHFKC--SCCDFSTDIKQSLTI 393
             ||.:    |.:|:.::..|..:::|          .||:......:|  ..|..:.|.|:...:
Human   731 DYHFL----CKACNLYSLSKEGMEKHIKRSKHLENAKKNNIGLSFEECIERVCIGANDKKEEFDV 791

  Fly   394 H-----ESNHHVPMPVHQMGNRSRDEAEDLVDQQSSGSRKPETFKNGGATVASTESLLPRTSGIV 453
            .     |.:..|.:..|....:....:|:|  .||.||.|.:..      .::|.....|..|.:
Human   792 SGNGRIEGHIGVQLQEHSYLEKGMLASEEL--SQSGGSTKDDEL------ASTTTPKRGRPKGNI 848

  Fly   454 ---CSHCQKRVGNAMQLINHLQ---------VCTLALHNT------------------TQLQAS- 487
               ||||.....:...|..|::         :|.:..:.|                  .:::||
Human   849 SRTCSHCGLLASSITNLTVHIRRKHSHQYSYLCKVCKYYTVTKGDMERHCATKKHKGRVEIEASG 913

  Fly   488 ---------------------INAEVDLHDEDFPNAPTDLSYCGVETAPGY-------------- 517
                                 ..:.|.:.|| ..|.|.: |...|...|..
Human   914 KHSSDIIVGPEGGSLEAGKKNAGSAVTMSDE-HANKPAE-SPTSVLEKPDRGNSIEAEVENVFHS 976

  Fly   518 --GEVT-------EVLPEEPEDLAPLKKVF-----------KCPHCSFWAATASRFHVHIV-GHL 561
              |||.       |.:..||||.|....|:           ||.||.|.|.:::...:|:. .|.
Human   977 LDGEVNSHLLDKKEQISSEPEDFAQPGDVYSQRDVTGTGENKCLHCEFSAHSSASLELHVKRKHT 1041

  Fly   562 NRKPFECSLCAYRSNWRWDITKHIRLKALRDRSHNQAQVLMNDETGRRNYAKYNQYLTMMKVSAE 626
            ....|.|..|.|.:..|.::|:|...:                    ::..|...||....|.|.
Human  1042 KEFEFYCMACDYYAVTRREMTRHAATE--------------------KHKMKRQSYLNSANVEAG 1086

  Fly   627 QLADSKGMRTGEMIVMPPEKLDDHHPMETEE--II--EMVDSAHSTSALDLRKPRDDQTEDL--- 684
            ....||.      |:||.|:    |...:||  ||  :..|:..|.:|.|.....::...|:
Human  1087 SADMSKN------IIMPEEE----HQQNSEEFQIISGQPSDTLKSRNAADCSILNENTNLDMSKV 1141

  Fly   685 --AGNSDELPQEGAKTEPNL-EPLSF-KSLNSSQVMPKPK--------------GSPMNLTKTDG 731
              |.:|.|:..|   .|.|. |..|| ::...:.|..|.:              |||......:.
Human  1142 LCAADSVEVETE---EESNFNEDHSFCETFQQAPVKDKVRKPEEMMSLTMSSNYGSPSRFQNENS 1203

  Fly   732 GQSD---ETTSADESNESD 747
            |.|.   ||...:....:|
Human  1204 GSSALNCETAKKNHEISND 1222

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kmg	NP_609604.1	C2H2 Zn finger	540..560	CDD:275370	6/20 (30%)
kmg	NP_609604.1	C2H2 Zn finger	568..586	CDD:275370	6/17 (35%)
ZNF407	NP_001371404.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..84
		C2H2 Zn finger	188..208	CDD:275368
		C2H2 Zn finger	217..238	CDD:275368
		C2H2 Zn finger	246..268	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	291..322
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	494..515
		C2H2 Zn finger	590..614	CDD:275371	8/23 (35%)
		C2H2 Zn finger	617..639	CDD:275371	8/41 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	667..700		9/32 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	821..847		8/33 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	910..962		10/53 (19%)
		C2H2 Zn finger	1416..1445	CDD:275371
		C2H2 Zn finger	1446..1468	CDD:275371
		C2H2 Zn finger	1488..1509	CDD:275371
		C2H2 Zn finger	1539..1561	CDD:275368
		zf-H2C2_2	1557..1578	CDD:404364
		C2H2 Zn finger	1569..1589	CDD:275368
		C2H2 Zn finger	1597..1617	CDD:275368
		C2H2 Zn finger	1630..1650	CDD:275368
		zf-H2C2_2	1642..1669	CDD:404364
		C2H2 Zn finger	1658..1680	CDD:275368
		C2H2 Zn finger	1688..1708	CDD:275368
		zf-H2C2_2	1700..1725	CDD:404364
		zf-H2C2_5	1714..1738	CDD:404746
		C2H2 Zn finger	1716..1736	CDD:275368
		zf-H2C2_2	1728..1753	CDD:404364
		C2H2 Zn finger	1744..1761	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100