DRSC/TRiP Functional Genomics Resources

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Protein Alignment kmg and prdm9

DIOPT Version :9

Sequence 1:NP_609604.1 Gene:kmg / 34706 FlyBaseID:FBgn0032473 Length:747 Species:Drosophila melanogaster
Sequence 2:NP_957196.1 Gene:prdm9 / 393876 ZFINID:ZDB-GENE-040426-1319 Length:853 Species:Danio rerio


Alignment Length:645 Identity:115/645 - (17%)
Similarity:188/645 - (29%) Gaps:276/645 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly    75 VSADSAPPGDLAKENMENSLPDGNPCN-NNNDDE---------------------------LPQC 111
            :|..:.|..:..:|.:  |..:|.|.: ..|.||                           |..|
Zfish   288 LSTQTQPVTESPQEQI--STQNGQPIHQTENSDEPDASDIYTAAGEISDEIHACVDCGRSFLRSC 350

  Fly   112 KIRRN----------YSCNQC-AFFTQ------NPRSHLSHLRDVH-----GERIVINECKLCLY 154
            .::|:          |.|:|| ..|:|      :..:|....:::.     .:.....:|.|...
Zfish   351 HLKRHQRTIHSKEKPYCCSQCKKCFSQATGLKRHQHTHQEQEKNIESPDRPSDIYPCTKCTLSFV 415

  Fly   155 ASRHF-QKLVRH-----MKMVHGCS------DDGGAV----QGSGAQP--RGKRNLSREVRKRRL 201
            |..:. |.|.||     :::|...|      :|...|    |....:|  ||:::         .
Zfish   416 AKINLHQHLKRHHHGEYLRLVESGSLTAETEEDHTEVCFDKQDPNYEPPSRGRKS---------T 471

  Fly   202 EESIEGQGATGQCLDLSVLRMIQNGPPLEQLKVELQQQEMQLLASVQAYNRQQEMLQLQQIVESH 266
            :.|::|:|...:   ::|.|.....|..:.|:||:|                    ::..|..:.
Zfish   472 KNSLKGRGCPKK---VAVGRPRGRPPKNKNLEVEVQ--------------------KISPICTNC 513

  Fly   267 DNIFSMAYEFQTKLMPPKQAESLKLEQQNSSSDSEETAKSPSPDTRELVSGKEQFQCQKCSYSTP 331
            :..||             ..|:||..|.....|..:..:.|..        ..|:.|.:|     
Zfish   514 EQSFS-------------DLETLKTHQCPRRDDEGDNVEHPQE--------ASQYICGEC----- 552

  Fly   332 IRARFKKHVKYHSMPLIK-------------CSSCDFHTPYKWNLDRH----------------- 366
            |||       :.::.|:|             |..||.:.....||.||                 
Zfish   553 IRA-------FSNLDLLKAHECIQQGEGSYCCPHCDLYFNRMCNLRRHERTIHSKEKPYCCTVCL 610

  Fly   367 ---TKNHGANGH---------------------FKCSCCDFSTDIKQSLTIHESNHHVPMPVHQM 407
               |::.|...|                     |.|:.|.||...::.|..|...||..|     
Zfish   611 KSFTQSSGLKRHQQSHLRRKSHRQSSALFTAAIFPCAYCPFSFTDERYLYKHIRRHHPEM----- 670

  Fly   408 GNRSRDEAEDLVDQQSSGSRKPETFKNGGATVASTESLLPRTSGIVCSHCQKRVGNAMQLINH-- 470
                              |.|..:|:.||  |.|.|.  |.:    ||.|.|.........||  
Zfish   671 ------------------SLKYLSFQEGG--VLSVEK--PHS----CSQCCKSFSTIKGFKNHSC 709

  Fly   471 ------LQVC-----TLALHNTTQLQASINAEVDLHDEDFPNAPTDLSYCGVETAPGYGEVTEVL 524
                  :.:|     ..:..|:.:....|:.                           ||     
Zfish   710 FKQGEKVYLCPDCGKAFSWFNSLKQHQRIHT---------------------------GE----- 742

  Fly   525 PEEPEDLAPLKKVFKCPHCSFWAATASRFHVHIVGHLNRKPFECSLCAYRSNWRWDITKH 584
                       |.:.|..|......:.:.:||:..|...|||.||.|........|:.:|
Zfish   743 -----------KPYTCSQCGKSFVHSGQLNVHLRTHTGEKPFLCSQCGESFRQSGDLRRH 791

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
kmgNP_609604.1 C2H2 Zn finger 540..560 CDD:275370 4/19 (21%)
C2H2 Zn finger 568..586 CDD:275370 5/17 (29%)
prdm9NP_957196.1 PR-SET_PRDM7_9 79..207 CDD:380970
Substrate binding. /evidence=ECO:0000250|UniProtKB:Q96EQ9 127..133
S-adenosyl-L-methionine binding. /evidence=ECO:0000250|UniProtKB:Q96EQ9 275..277
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 291..322 8/32 (25%)
COG5048 333..755 CDD:227381 95/560 (17%)
C2H2 Zn finger 339..360 CDD:275368 3/20 (15%)