DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kmg and znf131

DIOPT Version :9

Sequence 1:	NP_609604.1	Gene:	kmg / 34706	FlyBaseID:	FBgn0032473	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	NP_956799.2	Gene:	znf131 / 393477	ZFINID:	ZDB-GENE-040426-1563	Length:	558	Species:	Danio rerio

Alignment Length:	632	Identity:	107/632 - (16%)
Similarity:	199/632 - (31%)	Gaps:	204/632 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 FTQNP--------RSHLSHLRD--------VHGERIVINECKLCLYASRHFQKLVRHMKMVHGCS 173
            |||.|        .|...||.:        |:||..|.:..:...|.  ..|:.::.:
Zfish    66 FTQEPLVEIEGVSNSAFRHLMEFTYTATLAVNGEEEVSDVWRAAEYL--QMQEAIKAL------- 121

  Fly   174 DDGGAVQGSGAQPRGKRNLSREVRKRRLEESIEGQGATGQCLDLSVLRMIQNGPPLEQLKVELQQ 238
              .....|:.:...||    .:.:||::.|:            .:|:.........|.:::|::.
Zfish   122 --NNRRNGTTSPQPGK----SKAKKRKISET------------SNVITESLPSADTEAVEIEVEV 168

  Fly   239 QEMQLLASVQAYNRQQEMLQLQQIVESHDNIFSMAYEFQTKLMPPKQA-ESLKLEQQNSSSDSEE 302
            .|..:...........::.:...:..|.|:..::..:..:|....:|. ..:|...:......|.
Zfish   169 GEEHIEVEESGLVEVVDVARGTTVPSSDDSALALLADITSKYQQGEQTLHVIKKVDETVVVQEEA 233

  Fly   303 TAKSPSPDTRELVSGK-----EQFQCQKCSYSTPIRARFKKHVKYHSMPLIKCSSCDFHTPYKWN 362
            ...|.:.:..|:|..:     ..|:|.||.                     :|....:|
Zfish   234 VVASKTLENIEVVEVQISQLDNLFRCDKCD---------------------RCFKLYYH------ 271

  Fly   363 LDRHTKNHGANGH--FKCSCCDFSTDIKQSLTIHESNHHVPMPVHQMGNRSRDEAEDLVDQQSSG 425
            |.:|.|.|.|:..  |.|..|..:...:.:|..|.:|:|.             :||    :||..
Zfish   272 LKQHMKTHIASPERGFVCRHCGKAYAREGALKQHLNNYHF-------------DAE----EQSRR 319

  Fly   426 SRKPETFKNGGATVASTESLLPRTSGIVCSHCQKRVGNAMQLINHLQVCT-------LALHNTTQ 483
            .:|...                     ||.:|:|:..:......||:..|       ...|.
Zfish   320 QKKKVH---------------------VCEYCEKQFDHFGHFKEHLRKHTGEKPFECPECHE--- 360

  Fly   484 LQASINAEVDLHDEDFPNAPTDLSYCGVETAPGYGEVTEVLPEEPEDLAPLKKVFKCPHCSFWAA 548
             :.:.|:.:..|          :|.|...:....|.               ||:::|..||....
Zfish   361 -RFARNSTLKCH----------MSACQNGSGAKKGR---------------KKLYECQVCSSVFN 399

  Fly   549 TASRFHVHIVGHLNRKPFECSLCAYRSNWRWDITKHIRLKALRDRSHNQAQ--------VLMNDE 605
            :..:|..|:|.|...||..|:||........|:..|:       :.|:..|        :|::|.
Zfish   400 SWEQFKDHLVTHTGEKPNHCTLCDLWFTSPRDLHTHL-------QEHHSLQEKVIVAEDILISDP 457

  Fly   606 TGRRNYAKYNQYLTMMKVSAEQLADSKGMRTGEMIVMPPEKLDDHHPMETEE------------- 657
            ..          :..|:...|::....|:|...:.|.|.:.:.....:..||
Zfish   458 AN----------VLSMEEGEERVILEDGIRVEHVTVEPVDVVAVEETLVVEEETQIQPSQPEGGV 512

  Fly   658 ---IIEMVDSAH-STSALDLRKPRDDQTEDLAGNSDELPQEGAKTEP 700
               ::..|||.. ....:.::..|:...|         |.| ||.||
Zfish   513 AETVVLQVDSEKLKEQVMGIQVERETVAE---------PAE-AKQEP 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kmg	NP_609604.1	C2H2 Zn finger	540..560	CDD:275370	6/19 (32%)
kmg	NP_609604.1	C2H2 Zn finger	568..586	CDD:275370	5/17 (29%)
znf131	NP_956799.2	BTB	24..120	CDD:306997	13/55 (24%)
		zf-C2H2	257..279	CDD:306579	9/48 (19%)
		C2H2 Zn finger	259..279	CDD:275368	8/46 (17%)
		C2H2 Zn finger	289..347	CDD:275368	17/95 (18%)
		COG5048	<310..441	CDD:227381	36/204 (18%)
		C2H2 Zn finger	327..344	CDD:275368	3/16 (19%)
		zf-H2C2_2	339..364	CDD:316026	4/28 (14%)
		C2H2 Zn finger	355..372	CDD:275368	3/30 (10%)
		C2H2 Zn finger	419..439	CDD:275368	5/26 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100