DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kmg and CG4282

DIOPT Version :9

Sequence 1:	NP_609604.1	Gene:	kmg / 34706	FlyBaseID:	FBgn0032473	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	NP_611118.3	Gene:	CG4282 / 36825	FlyBaseID:	FBgn0034114	Length:	652	Species:	Drosophila melanogaster

Alignment Length:	635	Identity:	112/635 - (17%)
Similarity:	191/635 - (30%)	Gaps:	222/635 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 QKLVRHMKMVHGCS------DDGGAVQGSGAQPRGKRNLSREVRKRRLEESIEGQGATGQCLDLS 218
            ::|.:.:|...|.|      :||.......|.|:.:|.     |.|:.:.::    |..|
  Fly   163 RRLRKRLKAEDGSSVDKDKDEDGVEETAEPAPPKKRRG-----RPRKSDAAV----APPQ----- 213

  Fly   219 VLRMIQNGPPLEQLKVELQQQEMQ-------------LLAS------------------VQAYNR 252
                    .|.|.::::|:.:|:.             |:.|                  .:..|.
  Fly   214 --------KPKEDIQLDLKAEELDEFVDEETDPDFSCLVPSDNSSEDDGGSDGFDSDSDFELDNG 270

  Fly   253 QQEMLQLQQIVESHDNIFSMAYEFQTKLMPPKQAESLKLEQQNSSSDSEE--------TAKSPSP 309
            :||.    .::.....:....|:.:||...||...|.:|.:|......|.        |:..|..
  Fly   271 KQEF----AVLPKRTVVRPKKYKKRTKPAEPKVRMSRELLEQRKKQQEEYDVIIAKFFTSVLPCA 331

  Fly   310 DTRELVSGKEQFQ---------------CQKCSYSTPIRARFKKHVKYHSMP-LIKCSSCDFHTP 358
            ....||....:.|               |  |......|....:||..|..| ..|||.|:....
  Fly   332 ICNLLVHNFTEMQRHHRLTHQVDPGYMMC--CGRKFTQRKVLAEHVLVHWNPDHFKCSVCEKSFQ 394

  Fly   359 YKWNLDRHTKNH---GANGHFKCSCCDFSTDIKQSLTIHESNHHVPMPVHQMGNRSRDEAEDLVD 420
            ...:|:.|.:.|   .....|.|..|..:...|.::..|:.|.|||
  Fly   395 NSRHLESHQQVHMDPAVKLTFSCDLCSKTFLSKTAIDYHKLNKHVP------------------- 440

  Fly   421 QQSSGSRKPETFKNGGATVASTESLLPRTSGIVCSHCQKRVGNAMQLINHLQVCTLALHNTTQLQ 485
                   |.| ||                  ..||.|.|:.....:|.||:.
  Fly   441 -------KSE-FK------------------FTCSECNKKFLTERKLKNHMS------------- 466

  Fly   486 ASINAEVDLHDEDFPNAPTDLSYCGVETAPGYGEVTEVLPEEPEDL------APLKKVFKCPHCS 544
                   .:||   |.:......||.:..      |:::.::.::|      .|..::.:|..|.
  Fly   467 -------SMHD---PESTIICDKCGKQMR------TKIILKKHQELMHSDKPRPEPELQQCQICG 515

  Fly   545 FW--AATASRFHVHIVGHLNRKPFECSLCAYRSNWRWDITKHIRLKALRDRSHNQAQVLMNDETG 607
            .|  ..|..:.|:..:...:.....|.:||..|.         ..:|||      ..:..|.|..
  Fly   516 AWLKGMTGLKQHMKSIHVESAGEHRCHICAKVSP---------NARALR------RHIYHNHECE 565

  Fly   608 RRNYAKYNQYLTMMKVSAEQLADSKGMRTGEMIVMPPEKLDDHHPMETEEIIEMVDSAHST--SA 670
            |    |:.  .||.:.:.::                |::|.:|....|.|::....:...|  .:
  Fly   566 R----KFK--CTMCEKAFKR----------------PQELKEHTSTHTGEVLYTCPNCPMTFFCS 608

  Fly   671 LDLRKPRDDQTEDLAGNSDELPQEGAKTEPNLEPLSFKSLNSSQVMPKPK 720
            .::.|.|.        .......|..|.:|. .|...|...::....|||
  Fly   609 ANMYKHRQ--------RLHRAQYEADKNQPK-PPNILKISRNASTQNKPK 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kmg	NP_609604.1	C2H2 Zn finger	540..560	CDD:275370	5/21 (24%)
kmg	NP_609604.1	C2H2 Zn finger	568..586	CDD:275370	4/17 (24%)
CG4282	NP_611118.3	zf-AD	7..81	CDD:285071
		FYDLN_acid	<191..268	CDD:302856	13/98 (13%)
		C2H2 Zn finger	330..351	CDD:275368	3/20 (15%)
		C2H2 Zn finger	360..378	CDD:275368	5/19 (26%)
		LIM	361..>400	CDD:295319	10/38 (26%)
		C2H2 Zn finger	386..406	CDD:275368	5/19 (26%)
		zf-C2H2_8	389..465	CDD:292531	23/120 (19%)
		C2H2 Zn finger	417..438	CDD:275368	5/20 (25%)
		C2H2 Zn finger	448..465	CDD:275368	6/16 (38%)
		C2H2 Zn finger	477..498	CDD:275368	4/26 (15%)
		C2H2 Zn finger	511..532	CDD:275368	5/20 (25%)
		C2H2 Zn finger	541..562	CDD:275368	7/35 (20%)
		C2H2 Zn finger	570..590	CDD:275368	5/35 (14%)
		C2H2 Zn finger	598..619	CDD:275368	3/28 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444649
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030