DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kmg and CG30020

DIOPT Version :9

Sequence 1:	NP_609604.1	Gene:	kmg / 34706	FlyBaseID:	FBgn0032473	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	NP_610627.2	Gene:	CG30020 / 36156	FlyBaseID:	FBgn0050020	Length:	1309	Species:	Drosophila melanogaster

Alignment Length:	1050	Identity:	188/1050 - (17%)
Similarity:	305/1050 - (29%)	Gaps:	435/1050 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 VSADSAP--PGDLAKE----------NMENSL-----------PDGNPCNNN---NDDELPQC-- 111
            ||||:||  |..:..|          .::|:|           |..:...|.   .:.|.|.|
  Fly    66 VSADNAPELPQHICLECSKSLQVAYYFLQNALRAHEILCRKLCPKVSKRLNGTLAQEQEKPACAE 130

  Fly   112 -----KIRRNYSCNQCAFFTQNPRSHLSHLRDVHGERIVINECKLCLYASRHFQKLVRHMKMVHG 171
                 |..| :.|..|.....|......|:|. |.|.:..| ||||.:.|...:.|..|...:|.
  Fly   131 PVQPLKTMR-HECQVCGVVLYNRLELKQHIRQ-HAEGLSYN-CKLCSFTSLKQRTLFEHYVTMHN 192

  Fly   172 CSDDGGAVQGSGAQPRGKRNLSREVRKRRLEESIEGQGATGQCLDLSVLRMIQNGPPLEQLKVEL 236
            ..                  ||      :.||.::.:...              .|..|::|...
  Fly   193 MP------------------LS------QAEEYVKSKHLP--------------APKEEEVKAVC 219

  Fly   237 QQQEMQLLASVQAYNRQQEMLQLQQIVES-------HDNIFSM-----AYEFQTKLMPPKQAESL 289
            ..::|:||  :....|.::.:|....:::       |....||     :.:..|..:||....::
  Fly   220 TLEDMELL--IPTVLRPEDYVQPHPHIDNDQLRDIDHQLAVSMDEPVPSVDSLTSTLPPMDTPNV 282

  Fly   290 ------------KLEQQNSS-------SDSEETAKS---------------PSP-DTRELV---- 315
                        .|:|.|.|       .||:..:.|               |.. |..||:
  Fly   283 SIGTEYLVLPDGSLQQVNGSGVVIEYIDDSKPNSSSNVNVSLQNLLSSHNDPMDIDVNELIVEEM 347

  Fly   316 --------------SGKEQFQCQKCSYSTPIRARFKKHVKYHS-MPLIKCSSCDFHTPYKWNLDR 365
                          :...:.:|:.|..:....||.|.|...|| :|...|..|||::....:|.:
  Fly   348 MPQIRIKPKPAVIGTSIHKHKCKFCPKTFSTVARLKSHQLTHSNLPKFFCDQCDFYSLRSADLIQ 412

  Fly   366 HTK-------NHGANGH----------FKCSCCDFSTDIKQSLTIHESNHH-------------- 399
            |.|       .:|..|.          :.|..|.|.|.....|..|....|
  Fly   413 HYKMVHHRVDENGKTGKEQAQGIESRVYSCDMCLFETSTVSQLRTHYKERHTVQPTEVQLRPSWT 477

  Fly   400 ---------------------------------------VPMP---VHQMGNRSRDEAEDLVDQQ 422
                                                   .|:|   |||       ...|.:.|.
  Fly   478 GEPTTTRGVAAKQQTPAKILNHTDIPLGIKYPPGVLETQAPLPQPVVHQ-------PMPDPMQQT 535

  Fly   423 SSGSRKPETFKNGG-------AT----VASTESLL----------PRTSGIVCSHC--------- 457
            ...:....|....|       ||    .|::.|||          ..|:|...:|.
  Fly   536 EPMATTSTTITESGDINVVVDATPLFYAATSNSLLVTNPAPVTTVEETTGTASNHAFGIFPEISE 600

  Fly   458 ---------QKRVGN--AMQLINHLQ----------VCTLALHNTTQLQA--------SINAEVD 493
                     |:...|  ::.:...:|          :||:.......:..        :|:.:.|
  Fly   601 GNLPVNEAVQQAPANSSSVSVFGDMQDFIDNTDVAAICTIPADGMPVVDGDDIVIDNNNISLDFD 665

  Fly   494 LHD--EDFPNAPTDLSYCGVETAPGYGE------VTE---VLPEEPEDL--------APLKKVFK 539
            ..:  |||.....|......:.|....|      .|:   :|..:.:|:        ..|:|.:
  Fly   666 AENLFEDFEEEEDDTVADEEDEADNEDENDNNDAATDQNLLLTSDDDDVDDFDDEQSKHLQKPY- 729

  Fly   540 CPHCSFWAATASRFHVHIVGHLNRKPFECSLCAYRSNWRWDITKHIRL--KALRDRSHNQAQVLM 602
            |.:|:....:..:|..|:..|....|:.|.||....|.:..:.||.:.  |.:..|...||:
  Fly   730 CIYCNKKFTSQYKFENHMFVHRGLAPYRCELCTNLYNMKRLLIKHYKTVHKRMPTRDMVQAK--- 791

  Fly   603 NDE--TGRRNYAKY------NQYLTMMKVSAEQLADSK---------GMRTG------EMIV--- 641
            .|:  ..|.|..|.      |..|...|...|..:||:         |:..|      |:.:
  Fly   792 GDKVSVARTNIEKLYPGRIKNPMLMCAKCPFECESDSEMRKHLNAHHGINDGVSEHANEVFIIRK 856

  Fly   642 MPPE----------------KLDDHHPMETEEIIEM--------VDSAHSTSALDLRKPRDDQTE 682
            :|.|                .|...|.::|  ||||        :.:..:||:..:.:|.:..|.
  Fly   857 LPFECPRCIRSFAAKTTLSRHLQRSHLVDT--IIEMQTPHCGEAITTTMATSSSTISEPVNSVTV 919

  Fly   683 D------------------LAGNSD-----------------ELPQE------------------ 694
            |                  ..||.|                 .:|:|
  Fly   920 DGQHNEMMQTDVGAEKMTEALGNGDGNEEGGTDDGTGVKAEPAVPEEELDPVTLDAATAVTTTAI 984

  Fly   695 -------GAKTEPNLE-PLSFKSLNSSQVMPKP---------------KGSPMNLTKTDGGQSDE 736
                   .|.|..:|| |::..:.:|:.:.|.|               :.|| |:.......||.
  Fly   985 AAAISAAAAATATSLESPVATTASSSTTLFPTPTPFDFDYDIMRDEAQQSSP-NIHDVSKALSDN 1048

  Fly   737 TTSADESNES 746
            .:|:...|||
  Fly  1049 ASSSCPINES 1058

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kmg	NP_609604.1	C2H2 Zn finger	540..560	CDD:275370	4/19 (21%)
kmg	NP_609604.1	C2H2 Zn finger	568..586	CDD:275370	6/17 (35%)
CG30020	NP_610627.2	zf-AD	25..106	CDD:285071	10/39 (26%)
		C2H2 Zn finger	369..389	CDD:275368	6/19 (32%)
		C2H2 Zn finger	397..418	CDD:275368	7/20 (35%)
		C2H2 Zn finger	442..460	CDD:275368	6/17 (35%)
		C2H2 Zn finger	730..750	CDD:275368	4/19 (21%)
		C2H2 Zn finger	758..777	CDD:275368	6/18 (33%)
		C2H2 Zn finger	1089..1110	CDD:275368
		C2H2 Zn finger	1124..1144	CDD:275368
		C2H2 Zn finger	1151..1172	CDD:275368
		C2H2 Zn finger	1180..1203	CDD:275368
		C2H2 Zn finger	1210..1230	CDD:275368
		C2H2 Zn finger	1238..1254	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100