DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kmg and si:dkeyp-84f3.5

DIOPT Version :9

Sequence 1:	NP_609604.1	Gene:	kmg / 34706	FlyBaseID:	FBgn0032473	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	NP_001313282.1	Gene:	si:dkeyp-84f3.5 / 334144	ZFINID:	ZDB-GENE-050208-162	Length:	580	Species:	Danio rerio

Alignment Length:	713	Identity:	126/713 - (17%)
Similarity:	205/713 - (28%)	Gaps:	240/713 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RSGDRLVVRSLVSGAPLYQSSIE-----GGAGAV----LPMSQSVQPLIGQDFLEQ----QLEQY 60
            |.||..:......|..||...:|     |..|..    :....||.|.|.....|.    .:::.
Zfish    12 RGGDAFICTECGEGFRLYPKLVEHMAIHGLTGVFSSDGISNGSSVNPSIEVALHENGTLTVVDRS 76

  Fly    61 KANNFMFPLSMAGFVSADSAPPGDLAKENMENSLPDGNPCNNNNDDELPQC-------------- 111
            ..:||.|   :.|........|....:..:.:.:|:..|.....|    :|
Zfish    77 VLSNFTF---LFGKPQPKRFCPPPSQETIVPSKMPEKEPALYKCD----RCGQLFKTSKSLHLHQ 134

  Fly   112 ---KIRRNYSCNQCAFFTQNPRSHLSHLRDVHGERIVINECKLCLYASRHF---QKLVRHMKMVH 170
               .:.:.:.|..|.....:..|..:||::...||..     .|.:..:.|   ..|:.|.|..|
Zfish   135 QYRALEQGFKCTLCCKVLNDRESLQNHLQNHAHERFY-----SCGHCGKRFLRQDSLLSHQKQWH 194

  Fly   171 GCSDDGGAVQGSGAQPRGKRNLSREVRKRRLEESIEGQGATGQC-LDLSVLRMIQ---------N 225
            |.:              ..|.|||....:  |.|::.......| |....|..:|         |
Zfish   195 GSA--------------SSRILSRSQEDQ--ENSMDRSYPCKSCGLRFFWLSDLQSHLNSHSRVN 243

  Fly   226 GPPLEQLKVELQQQEMQLL---ASVQAYNRQ------QEMLQLQQIVESHDNIFSMAYEFQTKLM 281
            ..|.|.::.:...:|.:.:   :.:..:|..      |..|....:.|.|            |:.
Zfish   244 KSPNEVMQDQALGEENRKIDDNSVISQFNEPCCGLCGQNFLNTSDLREHH------------KVE 296

  Fly   282 PPKQAE-------SLKLEQQNSSSDSEETAKSPSPDTRELVSGKEQ-----------FQCQKCSY 328
            .|.:.|       ..|.:||.........||......|..:.||.:           |.|:.|..
Zfish   297 HPDEIEVKDSSVLPAKAKQQYHGVMRHMVAKQHKQLLRVNIKGKPKRINRATYTGKLFSCKHCHR 361

  Fly   329 STPIRARFKKHVKYHSMPLIKCSSCDFHTPYKWNLDRHTKNHGANGHFKCSCCDFSTDIKQSLTI 393
            .....:...:|::||...|..|..|..|.|.:.::.||...:.|:.             .||.:.
Zfish   362 VFVHSSSLSRHMRYHKGTLHACVYCGRHFPQRCDVTRHVAMYHASE-------------LQSKSQ 413

  Fly   394 HESNHHVPMPVHQMGNRSRDEAEDLVDQQSSGSRKPETFKNGGATVASTESLLPRTSGIVCSHCQ 458
            .||...     |:.||..::..::.....|.|.::
Zfish   414 EESTME-----HETGNGEQEPMKESTQTTSDGEQE------------------------------ 443

  Fly   459 KRVGNAMQLINHLQVCTLALHNTTQLQASINAEVDLHDEDFPNAPTDLSYCGVETAPGYGEVTEV 523
                                              ||.:|:.|::
Zfish   444 ----------------------------------DLEEENQPSS--------------------- 453

  Fly   524 LPEEPEDL--APLKKVF------KCPHCSFWAATASRFHVHIVGHLNRKPF----ECSLCAYRSN 576
               :.|||  :..||.|      ||..|.......|.|..|:|.| .|.|:    .|.||..|.:
Zfish   454 ---KSEDLFGSRFKKTFKPKMKYKCKECCRVFGLLSVFQRHMVHH-KRNPYRLLLSCPLCPSRFS 514

  Fly   577 WRWDITKHIRLKALRD--------RSHNQAQVLMNDETGRRNYAKYNQYLTMMKVSAEQLADS 631
            :...:.:|:.....||        ...|.....:..|.....|...|..:.|   |:|.|.:|
Zfish   515 FTSALNRHLECHHKRDPGTDVTKPPETNDINSQVQQEDSPTEYPDSNANIDM---SSEILNES 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kmg	NP_609604.1	C2H2 Zn finger	540..560	CDD:275370	6/19 (32%)
kmg	NP_609604.1	C2H2 Zn finger	568..586	CDD:275370	5/17 (29%)
si:dkeyp-84f3.5	NP_001313282.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100