DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kmg and Zfp335

DIOPT Version :9

Sequence 1:	NP_609604.1	Gene:	kmg / 34706	FlyBaseID:	FBgn0032473	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	XP_030107665.1	Gene:	Zfp335 / 329559	MGIID:	2682313	Length:	1338	Species:	Mus musculus

Alignment Length:	906	Identity:	178/906 - (19%)
Similarity:	277/906 - (30%)	Gaps:	359/906 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ELPSMVERSGDRLVVRSLVSGAPLYQSSI------EGGA-------------GAVLPMSQSVQPL 47
            :|.|.:::     ::.|.: |..|.||.|      ||||             ||.:..|.|...|
Mouse   127 DLGSAIDK-----IIESTI-GPDLIQSCITVTSGEEGGAETTQYLILQGPDDGAPMASSMSTSTL 185

  Fly    48 IGQDFLEQQLEQYKANNFMFPLSMAGFVSADSA---PPGDLAKENMENSLPDGNPCNNNNDDELP 109
                          ||:.....::|...::.||   ||.:          |.|:|.:
Mouse   186 --------------ANSLAAIEALADGPTSTSACLEPPEE----------PQGDPSS-------- 218

  Fly   110 QCKIRRNYSCNQCAFFTQNPRSHLSHLRDVHG-----ERIVINE--CKLCLYASRHFQKLVRHMK 167
                           ..|.|.:.::...|:..     |.:|:.:  ||:|.|.|.....|:|||:
Mouse   219 ---------------VAQQPPAPVTEELDLQSLEAMMEVVVVQQFKCKMCQYRSSTKATLLRHMR 268

  Fly   168 MVHGCSDDGGAVQGSGAQPRGKRNLSR----------EVRKRRLEE--SIEGQGATGQCLDLSVL 220
            ..|    ...|...:.|...|||...|          |.|....||  .|...||.....:.|..
Mouse   269 ERH----FRPAALAAAAAATGKRGRVRKWGTSTKTTEEDRPEEEEEDDDIVDAGAIDDLEEDSDY 329

  Fly   221 RMIQNGPPLEQLKVELQQQEMQLLASVQAYNRQQEMLQLQQIVESHDNIFSMAYEFQTKLMPPK- 284
            ...::.|...||:  ||:.........:...|.:::.:| :..:.||.:.......|:...||:
Mouse   330 NPAEDEPRGRQLR--LQRPTPSTPRPRRRPGRPRKLPRL-ETSDLHDGVGQPLVSSQSTQSPPEL 391

  Fly   285 ------QAESLK---------LEQQNSSSDSEETA------------------------------ 304
                  .:..|:         :|...|.||:|..|
Mouse   392 QDLEAPSSSGLRALGKVGRGLVESGVSQSDAENAAPSCQDEADAPPRRRGRPSRRFLGKKYRKYY 456

  Fly   305 -KSPSP------------------DTRELVSGKEQ-----FQCQKCSYSTPIRARFKKHVKYH-- 343
             |||.|                  |.|..|:..|.     |:|.:|||.:...:..|:|:..|
Mouse   457 YKSPKPLLRPYLCRICGSRFLSHEDLRFHVNSHEAGDPQLFRCLQCSYRSRRWSSLKEHMFNHVG 521

  Fly   344 SMPLIKCSSCDFHTPYKWNLDRHTKNHGAN-----------GHFKCSCCDFSTDIKQSLTIHESN 397
            |.| .||..|.:.:.|:.::.||...|..:           ..|.|..|.....:::.||.|...
Mouse   522 SKP-YKCDECSYTSVYRKDVIRHAAVHSQDRKKRPDPTPKLSSFPCPVCGRVYPMQKRLTQHMKT 585

  Fly   398 HHVPMPVHQMGNRSRDEAEDLVDQQSSGSRKPETFKNGGATVASTESLLPRTSGIVCSHCQKRVG 462
            |....|             .:.|:.....:|..|||
Mouse   586 HSTEKP-------------HMCDKCGKSFKKRYTFK----------------------------- 608

  Fly   463 NAMQLINHLQVCTLALHNTTQLQASINAEVDLHDEDFPNAPTDLSYCGVETAPGYGEVTEVLPEE 527
              |.|:.|:|
Mouse   609 --MHLLTHIQ------------------------------------------------------- 616

  Fly   528 PEDLAPLKKVFKCPHCSFWAATASRFHVHIVGHLNRKPFECSLCAYRSNWRWD-ITKHIRLKALR 591
                |...:.|||..|.|..........|.:.|::.|||:||.|.||: :|.| :..|:.:|
Mouse   617 ----AVANRRFKCEFCEFVCEDKKALLNHQLSHVSDKPFKCSFCPYRT-FREDFLLSHVAVK--- 673

  Fly   592 DRSHNQAQVLMNDETGRRNYA-KYNQYLTMMKVSAE--------QLADSKGMRTGEMIVMPPEKL 647
                         .||.:.:| :|..:.|..|.:..        ...:..|.|..|   .||.:
Mouse   674 -------------HTGAKPFACEYCHFSTRHKKNLRLHVRCRHANSFEEWGRRHPE---EPPSR- 721

  Fly   648 DDHHPMETEEIIEMVDSAHSTS-ALDLRKPRDDQTE----------------DLAGNSDELPQEG 695
              ..|..:.:.||.:...|||: ...|..|..:..:                |..|.:..:.|:|
Mouse   722 --RRPFFSLQQIEELKQQHSTAPGPPLSSPGPEAPQEPAPFQSPETPPLLCPDALGGTTIIYQQG 784

  Fly   696 AK------TEPNLEPLSFKSLNSS----------QV-MPKPKGSPMNLTKTDGGQSDETTS 739
            |:      |:..|:.|    ||.|          || :.|.:|....||.|.|..|.|.|:
Mouse   785 AEESTAVATQTALDLL----LNMSAQRELGATALQVAVVKSEGIEAELTSTGGQPSPEDTT 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kmg	NP_609604.1	C2H2 Zn finger	540..560	CDD:275370	4/19 (21%)
kmg	NP_609604.1	C2H2 Zn finger	568..586	CDD:275370	8/18 (44%)
Zfp335	XP_030107665.1	zf-H2C2_5	248..268	CDD:372805	8/19 (42%)
		C2H2 Zn finger	469..489	CDD:275368	3/19 (16%)
		C2H2 Zn finger	499..519	CDD:275368	6/19 (32%)
		zf-H2C2_2	511..536	CDD:372612	8/25 (32%)
		zf-H2C2_5	525..548	CDD:372805	6/22 (27%)
		C2H2 Zn finger	527..547	CDD:275368	5/19 (26%)
		C2H2 Zn finger	566..586	CDD:275368	5/19 (26%)
		zf-H2C2_2	578..603	CDD:372612	6/37 (16%)
		C2H2 Zn finger	594..614	CDD:275368	7/50 (14%)
		C2H2 Zn finger	625..645	CDD:275368	4/19 (21%)
		C2H2 Zn finger	653..674	CDD:275368	9/37 (24%)
		C2H2 Zn finger	682..701	CDD:275368	3/18 (17%)
		C2H2 Zn finger	1022..1042	CDD:275368
		SFP1	<1027..1127	CDD:227516
		C2H2 Zn finger	1050..1070	CDD:275368
		zf-H2C2_5	1076..1100	CDD:372805
		C2H2 Zn finger	1078..1098	CDD:275368
		zf-H2C2_2	1090..1115	CDD:372612
		C2H2 Zn finger	1106..1127	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834460
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030