DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kmg and Zfp462

DIOPT Version :9

Sequence 1:	NP_609604.1	Gene:	kmg / 34706	FlyBaseID:	FBgn0032473	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	XP_006537978.1	Gene:	Zfp462 / 242466	MGIID:	107690	Length:	2556	Species:	Mus musculus

Alignment Length:	857	Identity:	169/857 - (19%)
Similarity:	284/857 - (33%)	Gaps:	281/857 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 QDFLEQQLEQY--KANNFMFP-----LSMAGFVSADSA-----PPGDLAKENMENSLPDGNPCNN 102
            |.|.::.:..:  |.:..:||     ..:.|:.:|..|     ||  |.:|...:|.........
Mouse  1764 QSFSKKGIVSHYMKRHPGVFPKKQHASKLGGYFTAVYADEHEKPP--LMEEEERSSFERAEVEGE 1826

  Fly   103 NNDDE-LP----QCKIRRNYSCNQ--CAFFTQNPRSHLSHLRDVHGERIVIN----------ECK 150
            ..|.| ||    :| .:.::|..:  |..:|.:      |.||:..:.:::.          :||
Mouse  1827 AQDIEWLPFRCIKC-FKLSFSTAELLCMHYTDH------HSRDLKRDFVILGSGPRFQNSTFQCK 1884

  Fly   151 LCLYASRHFQKLVRHMKMVHGCSDDGGAVQGSGAQPRGKRNLSREVRKRRLEESIEGQGATGQCL 215
            .|....:...:|..|:.           :.....|.|.||   :|.||:.|.:.....||.....
Mouse  1885 HCDSKLQSIAELTSHLN-----------IHNEEFQKRAKR---QERRKQLLSKQKYADGAFADFK 1935

  Fly   216 DLSVLRMIQNGPPLEQLKVELQQQEMQLLASVQAYNRQQEMLQLQQIVESHDNIFSMAYEFQTKL 280
            .......::..|.:::.|             |..|       :.:..||.|..:.::....:..:
Mouse  1936 QERPFGHLEEVPKIKERK-------------VVGY-------KCKFCVEVHPTLRAICNHLRKHV 1980

  Fly   281 M---PPKQAESLKLEQQNSSS---DSEETAKSPS-------------------PDTR-------- 312
            .   .|..:.::|.|.::.|.   |..|.|:..|                   .:||
Mouse  1981 QYGSVPAVSAAVKQEAEDPSHLFLDGLEAARDASGTLVGRVDGGHCLLDAMLEDETRPGGYHCSQ 2045

  Fly   313 ---------------------ELVSGKEQFQCQKCSYSTPIRARFKKHVKY---HSMPLIKCSSC 353
                                 .:.:.::::.||.||:.:..|....:|::.   |..| .:|..|
Mouse  2046 CDRVLMSMQGLRSHERSHLALAMFTREDKYSCQYCSFVSAFRHNLDRHMQTHHGHHKP-FRCKLC 2109

  Fly   354 DFHTPYKWNLDRH-TKNHGANGHFKCSCCDFST----DIKQ-SLTIHESNHHVPMP--------- 403
            .|.:.|...|..| .|.|.....:|||.|.|||    .:|: ||.:|.....:|.|
Mouse  2110 SFKSSYNSRLKTHILKAHAGEHAYKCSWCSFSTMTISQLKEHSLKVHGKALTLPRPRIVSLLSSH 2174

  Fly   404 VHQMGNRS--RDEAEDLVDQQSSGSRKPETFKNGGATVASTESLLPRTSGIVCSHCQKRVGNAMQ 466
            .|....::  .:|.||..|  ||.|..|:                                 ..|
Mouse  2175 AHPSSQKATPAEEVEDSND--SSYSEPPD---------------------------------VQQ 2204

  Fly   467 LINHLQVCTLALHNT---------TQLQASINAEVDLHDEDFPNAPTDLSYCGVETAPGYGEVTE 522
            .:||.|...||.:.:         |.......||..||.|          :|  |.:.||   .:
Mouse  2205 QLNHYQSAALARNKSRVSPVPPSGTAAGTEQKAEAVLHCE----------FC--EFSSGY---IQ 2254

  Fly   523 VLPEEPEDLAPLKKVFKCPHCSFWAATASRFHVHI-VGHL-----NRKPFECSLCAYRSNWRWDI 581
            .:.....|....||:|||..|||:....|.|.:|: .||.     ..|...|.||.|.:.::.::
Mouse  2255 SIRRHYRDKHGGKKLFKCKDCSFYTGFKSAFTMHVEAGHSAVPEEGPKDLRCPLCLYHTKYKRNM 2319

  Fly   582 TKHIRLKALRDRSHNQAQVL---------------------------MNDETGRRNYAKYNQYLT 619
            ..||.|       |.:.:|:                           .:||:.:::..|:|:
Mouse  2320 IDHIVL-------HREERVVPIEVCRSKLSKYLQGVVFRCDKCTFTCSSDESLQQHIEKHNE--- 2374

  Fly   620 MMKVSAEQLADSKGMRTGEMIVMPPEKLDDHHP----------METEEIIEMVDSAHSTSALDLR 674
             :|....||...:...|.|:    ...|.|.|.          :..:::.:|.:...|:|:.|
Mouse  2375 -LKPYKCQLCYYETKHTEEL----DTHLRDEHKVSRNFELVGRVNLDQLEQMKEKIESSSSED-- 2432

  Fly   675 KPRDDQTEDLAGN------SDELPQEGAKTEPNLEPLSFKSLNSSQVMPKPKGSPMNLTKTDGGQ 733
            :.:||:....|.:      :|..|  |..||... |..|.....||      ||.........|.
Mouse  2433 EDKDDEMSSKAEDRELMRFADRGP--GVNTEKRF-PCEFCGRAFSQ------GSEWERHVLRHGM 2488

  Fly   734 SDETTSADESNE 745
            |...|:....||
Mouse  2489 SLHDTNQVSRNE 2500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kmg	NP_609604.1	C2H2 Zn finger	540..560	CDD:275370	7/20 (35%)
kmg	NP_609604.1	C2H2 Zn finger	568..586	CDD:275370	5/17 (29%)
Zfp462	XP_006537978.1	C2H2 Zn finger	2043..2063	CDD:275368	0/19 (0%)
		zf-H2C2_5	2075..2099	CDD:404746	6/23 (26%)
		C2H2 Zn finger	2077..2097	CDD:275368	6/19 (32%)
		C2H2 Zn finger	2106..2127	CDD:275368	7/20 (35%)
		C2H2 Zn finger	2135..2156	CDD:275368	9/20 (45%)
		C2H2 Zn finger	2306..2326	CDD:275368	7/26 (27%)
		C2H2 Zn finger	2352..2372	CDD:275368	2/19 (11%)
		C2H2 Zn finger	2380..2401	CDD:275368	6/24 (25%)
		C2H2 Zn finger	2466..2486	CDD:275368	5/25 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC9A
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.960