DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kmg and Zfp646

DIOPT Version :9

Sequence 1:	NP_609604.1	Gene:	kmg / 34706	FlyBaseID:	FBgn0032473	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	NP_766337.2	Gene:	Zfp646 / 233905	MGIID:	3665412	Length:	1788	Species:	Mus musculus

Alignment Length:	647	Identity:	128/647 - (19%)
Similarity:	207/647 - (31%)	Gaps:	174/647 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 CLYASRHF---QKLVRHMKMVH-GCSDDGGAVQG----SGAQPRGKRNLSREVRKRRLEESIEGQ 208
            |....|||   .:|.||.::.| ....||....|    .|:.|....|..|.........:..|:
Mouse    10 CSDCQRHFPNLPELARHRELRHSSAKQDGEEADGIPHPYGSHPENLANHQRNHETLFFPCTTCGK 74

  Fly   209 GATGQCLDLSVLRM------IQNGPP-LEQLKVELQQQEM------QLLASVQAYNRQQEMLQLQ 260
            ..:.:....|.:|.      .::||| ..:....|..:.|      |.|.|.:.:..|.::::
Mouse    75 DFSNRLALQSHMRTHAPESHRRHGPPHAMETAPHLGSETMATDSWGQRLGSGEGWENQTKLVR-- 137

  Fly   261 QIVESHD-------NIFSMAYEFQTKLMPPKQAESLKLEQQNSSS--------DSEETAKSPSPD 310
               |:||       ...|..:|..    |.||.:.|:::..:...        .||..:..|:|.
Mouse   138 ---ETHDWESGADPRAASGTWEDP----PTKQRQGLEMQPDSKGGTADWVPAVSSEGASPLPTPA 195

  Fly   311 TREL-------------------------VSGKEQFQCQKCSYSTPIRARFKKHVKYHSMPLIKC 350
            :..|                         ..|:.:::|.:|..:.........|.:.|::.:..|
Mouse   196 SNLLSNLEQYLAESVVNFTEAQEPTEPLPTEGERKYRCSECGKTYKHAGSLTNHRQSHTLGIYPC 260

  Fly   351 SSCDFHTPYKWNLDRHTKNHGANGHFKCSCCDFSTDIKQSLTIHESNHHVPMPVHQMGNRSRDEA 415
            |.|.........|..|::.|.....:.|..|..:..:.:.|..|:.:|.        |.:.....
Mouse   261 SICFKEFSNLMALKNHSRLHAQYRPYHCPHCPRAFRLPRDLLEHQQSHE--------GLKQEQPW 317

  Fly   416 EDL--------VDQQSSGSRKPETFKNGGATVASTESLLPRTS----GIVCSHCQKRVGNAMQLI 468
            ||.        .|::|.|........||...::|:..|....|    ...|..|.:...:|..||
Mouse   318 EDKEMPTTNGHADERSWGQLSKTGMLNGSGELSSSGQLEDGGSEEYRPFCCGDCGRTYRHAGSLI 382

  Fly   469 NH----------LQVCTLALHNTTQLQASINAEVDLHDEDFPNAPTDLSYCGVETAPGYGEVTEV 523
            ||          ..:|:..|.|...|:..|.|.............:.:|...:.:|....:|.||
Mouse   383 NHRKSHQTGIYPCSICSKQLFNAAALKNHIRAHHRPRQGAGEGGQSSVSSTALTSAENTPKVDEV 447

  Fly   524 LPEEPEDLAPLKKVFKCPHCSFWAATASRFHVHIVGHLNRK---PFECSLCAYRSNWRWDITKHI 585
             |....|..|    :||..|    ..|.|....:|.|.:..   .::||||.         .|:.
Mouse   448 -PTASLDHRP----YKCNEC----GRAYRHRGSLVNHRHSHRTGEYQCSLCP---------RKYP 494

  Fly   586 RLKALRD--RSHNQAQVLMND--ETGRRNYAKYNQYLTMMKVSAEQLADSKGMRT---GEMIVMP 643
            .|.|||:  |.|.:|.....|  ..|..:..|..|:            |..||..   |
Mouse   495 NLMALRNHVRVHCKATRRSTDPGTEGSPSPVKKEQH------------DPVGMEAAFHG------ 541

  Fly   644 PEKLDDHHPMETEE----------------------IIEMVDSA--HSTSALDLRKPRDDQT 681
                |:.|..:.||                      :.|.:.|.  ||.:..:..|.|.|.|
Mouse   542 ----DEEHACKREEEATSNPSMADRTVPQVCSICGMLFEDLKSLEHHSVTHREGEKSRTDST 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kmg	NP_609604.1	C2H2 Zn finger	540..560	CDD:275370	5/19 (26%)
kmg	NP_609604.1	C2H2 Zn finger	568..586	CDD:275370	5/17 (29%)
Zfp646	NP_766337.2	C2H2 Zn finger	10..31	CDD:275368	7/20 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..48		4/19 (21%)
		C2H2 Zn finger	69..89	CDD:275368	3/19 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..196		12/60 (20%)
		C2H2 Zn finger	233..253	CDD:275368	3/19 (16%)
		C2H2 Zn finger	260..280	CDD:275368	5/19 (26%)
		C2H2 Zn finger	288..308	CDD:275368	4/19 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	306..360		11/61 (18%)
		C2H2 Zn finger	368..388	CDD:275368	7/19 (37%)
		C2H2 Zn finger	395..415	CDD:275368	5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	416..449		5/33 (15%)
		C2H2 Zn finger	459..479	CDD:275368	6/23 (26%)
		C2H2 Zn finger	486..506	CDD:275368	10/28 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	509..531		5/33 (15%)
		C2H2 Zn finger	568..588	CDD:275368	4/19 (21%)
		C2H2 Zn finger	608..628	CDD:275368
		C2H2 Zn finger	635..655	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	651..712
		C2H2 Zn finger	808..828	CDD:275368
		C2H2 Zn finger	835..855	CDD:275368
		C2H2 Zn finger	868..886	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	889..916
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	956..976
		C2H2 Zn finger	1037..1057	CDD:275368
		C2H2 Zn finger	1064..1084	CDD:275368
		C2H2 Zn finger	1172..1192	CDD:275368
		C2H2 Zn finger	1199..1219	CDD:275368
		C2H2 Zn finger	1227..1247	CDD:275368
		C2H2 Zn finger	1268..1285	CDD:275368
		C2H2 Zn finger	1295..1315	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1351..1386
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1398..1439
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1455..1489
		C2H2 Zn finger	1500..1518	CDD:275368
		C2H2 Zn finger	1526..1544	CDD:275368
		C2H2 Zn finger	1552..1572	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1579..1629
		C2H2 Zn finger	1642..1662	CDD:275368
		C2H2 Zn finger	1669..1689	CDD:275368
		zf-H2C2_2	1681..1706	CDD:372612
		C2H2 Zn finger	1697..1717	CDD:275368
		C2H2 Zn finger	1726..1746	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1744..1788
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100