DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kmg and lin-13

DIOPT Version :9

Sequence 1:	NP_609604.1	Gene:	kmg / 34706	FlyBaseID:	FBgn0032473	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	NP_498678.3	Gene:	lin-13 / 176083	WormBaseID:	WBGene00003002	Length:	2248	Species:	Caenorhabditis elegans

Alignment Length:	1037	Identity:	175/1037 - (16%)
Similarity:	280/1037 - (27%)	Gaps:	504/1037 - (48%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 RNYSCNQCA---FFTQNPRSHLSHLRDVHGERIVINECKLCLYASRHFQKLVRHMK--MVHGCSD 174
            |.|||. |:   || .:|.....|...||   |:.|:|:||.|.:.....:|:|.|  |..||
Worm  1278 RVYSCT-CSPNKFF-NSPIEFCDHFDSVH---ILRNKCQLCSYDAPSQDGMVKHRKTHMRSGC-- 1335

  Fly   175 DGGAVQGSGAQPRGKRNLSREVRKRRLEESIEGQGATGQCL----DLSVLRMIQNGP-PLEQLKV 234
                              .:|..|:..        ...:||    :...:|.|:.|| |.....|
Worm  1336 ------------------PKEQTKKLF--------ILMKCLFPKHNSGYMRFIEGGPVPASYQDV 1374

  Fly   235 ELQQQEMQLL-----------ASVQAYNRQQEMLQ----------LQQIVE--------SHDNIF 270
            :..|....:.           :..||.....|.|:          ||::|.        |..::.
Worm  1375 DRSQMNYLMCNMGTVSPSCHKSYAQAPRTLLEALEGVASDSRSGGLQKVVNVTTRMNEPSSSDVI 1439

  Fly   271 SMAYE-------FQTKLMP-----------PKQAESLKLE-------------QQNSSSDSEET- 303
            .::.:       |: |.:|           |....|:..|             ||....|.::|
Worm  1440 MLSDDEDDDCVVFE-KAVPNGVAQGSSTSTPNPESSINCEVRVETSQAGYGGAQQPGYVDEDDTD 1503

  Fly   304 ------AKSP--SPDTRELV--------------------------SGKE-QFQCQKCS------ 327
                  .|||  .|..:|:|                          :|:| :|:|||||
Worm  1504 LEVAQGGKSPYGEPVVKEVVDENGDDELAVVAEVENSTGTLPSSISAGREKKFKCQKCSLAFYTN 1568

  Fly   328 ----------------------YSTPI-----------------RARFKKHVKYHS---MPLIKC 350
                                  |..|:                 :.:::||:..|.   :..|.|
Worm  1569 GSLESHMRDHRQDAGAQLCTETYGIPVVTKASWLCRNCCVVFENQPKYQKHMAIHGDTCLTCIHC 1633

  Fly   351 SSCDF-HTPYKWNLDRHTKN--------------------------HGANGHFKCSCCDFST--- 385
            |...| ||..:.::..|.:.                          ||.:.::.|..|.|.:
Worm  1634 SGIAFNHTAIQNHMKSHEEKKVRYSCGTCLCTFASDLALFDHLSVAHGVSLYYFCKVCGFGSTSA 1698

  Fly   386 -DIKQSLTIHES----------------------------------------------------- 396
             .:.|.::||..
Worm  1699 DSVFQHISIHNGHNYSLVQRFGACPAQLLNYDPTDELEFRSQILNKTIQLVSPSDCSHRSMLLQC 1763

  Fly   397 ---------------------NHH---------------------VPMPVH----------QMGN 409
                                 |:|                     .|:..|          |.||
Worm  1764 ETVVSCKTCHCTQAWFNYMAFNNHSEETGFPQFKNVDLANDYRRDFPLSRHLNERNALSMSQFGN 1828

  Fly   410 RSRDEAEDLVDQ-----------------------QSSGSRKPETFKNGGATV------------ 439
            .....|.....|                       |::||.......|||..|
Worm  1829 AKHGSANHSHGQAQPNKRTFRHEVPYRTAAPRSSLQTNGSSMGSVTTNGGRVVRPSPPNSMNVTL 1893

  Fly   440 --ASTESLLPRTSGIVCSHCQKRVGNAMQLINHLQV--------CTLALHNTTQLQA-------- 486
              |..:...||.  ||.::......|.::  ||:.|        |...||:....|.
Worm  1894 RRAPPQQAPPRR--IVIANSAPNNTNVLR--NHVAVTTKCQFKDCDKVLHSEFDRQLHSMHSSNS 1954

  Fly   487 ---------SINAEVDLHDEDFPNAPTDLSYCGVETAPGYGEVTEVLPEEPEDLAPLKKVF--KC 540
                     |..:|:||.          |.|..|...|.|        ::.:..:....||  ||
Worm  1955 SWFCRQCGHSPKSEIDLF----------LHYIQVHLKPAY--------DKHQSNSFKSNVFHLKC 2001

  Fly   541 P--HCS---FWAATASRFHVHIVGHLNRKPFECSLCAYR-------------------SNW---- 577
            |  .|:   |.:..|...|:. ..|....|||.|.|..|                   ||.
Worm  2002 PIRSCTSPEFQSPKAFEKHMR-TAHAAELPFEASCCDARFASKALCVKHDQEHASFLDSNGTDAS 2065

  Fly   578 ---------RWDITK---------HIRLKALRDRSH------------NQAQVLMN--------- 603
                     .|.:.|         ||....|..||.            ||.||:.:
Worm  2066 CCPICGSLSMWSLPKDPHTDCLQSHIIRHGLDYRSSCRQCLKQFPADVNQDQVIAHILDTHGMSM 2130

  Fly   604 ---------DETGRRNYAKYNQYLTMMKVSAEQLADSKGMRTGEMIVMPPEKLDDHHPME--TEE 657
                     ..||.:...::.::.....|....:..|...| ||::|...::.:::..::  |..
Worm  2131 HGNTFHCNLCTTGTKTVEEFAEHCRKAHVFHILVKSSHSTR-GELVVTTGQEYENYVGLKSVTRA 2194

  Fly   658 IIEMVDSAHSTSALDLRKPRDDQTEDL---AGNSDELPQEGAKTEPNLEPLSFKSLNSSQVM 716
            .:..:.|..:::|.:..:|     ..|   :||:..|....|..||.      .|.|:::|:
Worm  2195 SLNSISSQRASNAGETAQP-----SVLCAGSGNAALLTIAAAIGEPE------TSNNTAEVL 2245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kmg	NP_609604.1	C2H2 Zn finger	540..560	CDD:275370	6/24 (25%)
kmg	NP_609604.1	C2H2 Zn finger	568..586	CDD:275370	8/58 (14%)
lin-13	NP_498678.3	C2H2 Zn finger	961..982	CDD:275368
lin-13	NP_498678.3	C2H2 Zn finger	986..1003	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100