DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kmg and Zfp91

DIOPT Version :9

Sequence 1:	NP_609604.1	Gene:	kmg / 34706	FlyBaseID:	FBgn0032473	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	NP_443735.2	Gene:	Zfp91 / 109910	MGIID:	104854	Length:	572	Species:	Mus musculus

Alignment Length:	471	Identity:	87/471 - (18%)
Similarity:	147/471 - (31%)	Gaps:	173/471 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 RGKRNLSRE--VRKRRLEESIEGQGATGQCLDLSVLRMIQNGPPLEQLKVELQQQEMQL--LASV 247
            |..|:.||.  .|.|..|.:...:..||     |:..:.:..|..:||..::.::....  ::|.
Mouse   151 RSWRSSSRTSISRLRDSENTRSSRSKTG-----SLQLVCKTEPITDQLDYDVPEEHQSPGGISSD 210

  Fly   248 QAYNRQQEMLQLQQIV----ESHDNIFSMAYEFQT--------KLMPPKQAESLKL-------EQ 293
            :....::|||..::.:    :..|..:....|.:|        |:...|:.:.:|:       |:
Mouse   211 EEEEEEEEMLISEEEIPFKDDPRDETYKPHLERETPKPRRKSGKVKEEKEKKEIKVEVEVEVKEE 275

  Fly   294 QNSSSDSEETA----------KSPSPDTRELVSGKEQFQCQ------------------------ 324
            :|...:.||..          |||....|......:..:|:
Mouse   276 ENEIREDEEPPRKRGRRRKDDKSPRLPKRRKKPPIQYVRCEMEGCGTVLAHPRYLQHHIKYQHLL 340

  Fly   325 KCSYSTP---------IRARFKKHVKYHS------------------------------MPLIKC 350
            |..|..|         ::.:..:|.|:|:                              .|| :|
Mouse   341 KKKYVCPHPSCGRLFRLQKQLLRHAKHHTDQRDYICEYCARAFKSSHNLAVHRMIHTGEKPL-QC 404

  Fly   351 SSCDFHTPYKWNLDRHTKNHGANG--HFKCSCCDFSTDIKQSLTIHESNHHVPMPVHQMGNRSRD 413
            ..|.|....|.:|:.|.|.|.|:.  .|.|:.|....:.|.|:..|::..|..:.:
Mouse   405 EICGFTCRQKASLNWHMKKHDADSFYQFSCNICGKKFEKKDSVVAHKAKSHPEVLI--------- 460

  Fly   414 EAEDLVDQQSSGSRKPETFKNGGATVASTESLLPRTSGIVCSHCQKRVGNAMQLINHLQVCTLAL 478
             ||.|.             .|.||.:.||:.|......:.    |...|..:.|:..      .|
Mouse   461 -AEALA-------------ANAGALITSTDILGTNPEPLT----QPADGQGLPLLPE------PL 501

  Fly   479 HNTTQLQASINAEVDLHDEDFPNAPTDLSYC-GVE----TAPG---------------------Y 517
            .|:|..:..:     |..|....     ||| |.|    .|.|                     .
Mouse   502 GNSTAGECLL-----LEAEGMSK-----SYCSGTERVSLMADGKIFVGSGSSGGTEGLVMNSDIL 556

  Fly   518 GEVTEVLPEEPEDLAP 533
            |..||||.|:.:...|
Mouse   557 GATTEVLIEDTDSTGP 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kmg	NP_609604.1	C2H2 Zn finger	540..560	CDD:275370
kmg	NP_609604.1	C2H2 Zn finger	568..586	CDD:275370
Zfp91	NP_443735.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..308		31/161 (19%)
		zf-C2H2_8	315..392	CDD:292531	7/76 (9%)
		Interaction with MAP3K14/NIK. /evidence=ECO:0000250	340..370		6/29 (21%)
		C2H2 Zn finger	349..368	CDD:275368	2/18 (11%)
		C2H2 Zn finger	376..396	CDD:275368	0/19 (0%)
		zf-H2C2_2	388..413	CDD:290200	5/25 (20%)
		C2H2 Zn finger	404..424	CDD:275368	7/19 (37%)
		C2H2 Zn finger	434..450	CDD:275368	4/15 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100