DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pk34A and Gsk3a

DIOPT Version :9

Sequence 1:	NP_609603.1	Gene:	Pk34A / 34705	FlyBaseID:	FBgn0028410	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_001026837.1	Gene:	Gsk3a / 606496	MGIID:	2152453	Length:	490	Species:	Mus musculus

Alignment Length:	359	Identity:	149/359 - (41%)
Similarity:	210/359 - (58%)	Gaps:	17/359 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 SVISTYAVG-RLCSEPALVRIEVKDLIGSGSFGRVYQAHVNESEEIVAVKQTLYNPKLSQGEAEI 88
            :|::|...| ....|.|...|:|   ||:||||.||||.:.|:.|:||:|:.|.:.:....|.:|
Mouse   102 TVVATVGQGPERSQEVAYTDIKV---IGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQI 163

  Fly    89 MGQLKDHNNIVRL--IMHSSVSLGFPSVD-YVLLVMEYMPMTLLDYINYHLTVLQPAERLINVRI 150
            |.:| ||.|||||  ..:||   |....: |:.||:||:|.|:. .:..|.|..:....:|.:::
Mouse   164 MRKL-DHCNIVRLRYFFYSS---GEKKDELYLNLVLEYVPETVY-RVARHFTKAKLITPIIYIKV 223

  Fly   151 LSYQMFRGLGYLHLLGISHRDVKPENLLIDNQKMVLKLSDFGSAKLLVPQEPSISYICSRLYRAP 215
            ..||:||.|.|:|..|:.|||:||:|||:|....||||.||||||.||..||::||||||.||||
Mouse   224 YMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAP 288

  Fly   216 ELFAGYELYSCAVDIWSAGCVLAELLKGYPLFSSHKHDRKQLRLIVNMLGTDGLERAPEILSKCG 280
            ||..|...|:.::|:|||||||||||.|.|:|.... ...||..|:.:|||...|:..|:.....
Mouse   289 ELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDS-GVDQLVEIIKVLGTPTREQIREMNPNYT 352

  Fly   281 NSLHPRTTRPSWNYLLNTA-VPQDLCGLLNSCFIYEAAARISPMMACSHGSYDELRIMDAMALPM 344
            ....|:.....|..:..:: .|.:...|.:|...|..::|:||:.||:|..:||||.:.|.   :
Mouse   353 EFKFPQIKAHPWTKVFKSSKTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRRLGAQ---L 414

  Fly   345 PNGNPLPPLFDFNSLEMGTDPKLWVNLLPIHLSS 378
            ||..||||||:|:..|:...|.|...|:|.||.|
Mouse   415 PNDRPLPPLFNFSPGELSIQPSLNAILIPPHLRS 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pk34A	NP_609603.1	STKc_GSK3	39..334	CDD:271039	124/298 (42%)
Pk34A	NP_609603.1	S_TKc	45..328	CDD:214567	120/286 (42%)
Gsk3a	NP_001026837.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..97
		STKc_GSK3	114..407	CDD:271039	125/301 (42%)
		Pkinase	119..404	CDD:278497	122/293 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	451..490
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	41	1.000	Domainoid score	I12448
eggNOG	1	0.900	-	-		E2759_KOG0658
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.770