DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pk34A and GSK3A

DIOPT Version :9

Sequence 1:	NP_609603.1	Gene:	Pk34A / 34705	FlyBaseID:	FBgn0028410	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_063937.2	Gene:	GSK3A / 2931	HGNCID:	4616	Length:	483	Species:	Homo sapiens

Alignment Length:	358	Identity:	148/358 - (41%)
Similarity:	209/358 - (58%)	Gaps:	16/358 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 SVISTYAVG-RLCSEPALVRIEVKDLIGSGSFGRVYQAHVNESEEIVAVKQTLYNPKLSQGEAEI 88
            :|::|...| ....|.|...|:|   ||:||||.||||.:.|:.|:||:|:.|.:.:....|.:|
Human   102 TVVATLGQGPERSQEVAYTDIKV---IGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQI 163

  Fly    89 MGQLKDHNNIVRL--IMHSSVSLGFPSVD-YVLLVMEYMPMTLLDYINYHLTVLQPAERLINVRI 150
            |.:| ||.|||||  ..:||   |....: |:.||:||:|.|:. .:..|.|..:....::.|::
Human   164 MRKL-DHCNIVRLRYFFYSS---GEKKDELYLNLVLEYVPETVY-RVARHFTKAKLTIPILYVKV 223

  Fly   151 LSYQMFRGLGYLHLLGISHRDVKPENLLIDNQKMVLKLSDFGSAKLLVPQEPSISYICSRLYRAP 215
            ..||:||.|.|:|..|:.|||:||:|||:|....||||.||||||.||..||::||||||.||||
Human   224 YMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAP 288

  Fly   216 ELFAGYELYSCAVDIWSAGCVLAELLKGYPLFSSHKHDRKQLRLIVNMLGTDGLERAPEILSKCG 280
            ||..|...|:.::|:|||||||||||.|.|:|.... ...||..|:.:|||...|:..|:.....
Human   289 ELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDS-GVDQLVEIIKVLGTPTREQIREMNPNYT 352

  Fly   281 NSLHPRTTRPSWNYLLNTAVPQDLCGLLNSCFIYEAAARISPMMACSHGSYDELRIMDAMALPMP 345
            ....|:.....|..:..:..|.:...|.:|...|..::|:||:.||:|..:||||   .:...:|
Human   353 EFKFPQIKAHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELR---CLGTQLP 414

  Fly   346 NGNPLPPLFDFNSLEMGTDPKLWVNLLPIHLSS 378
            |..||||||:|::.|:...|.|...|:|.||.|
Human   415 NNRPLPPLFNFSAGELSIQPSLNAILIPPHLRS 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pk34A	NP_609603.1	STKc_GSK3	39..334	CDD:271039	124/297 (42%)
Pk34A	NP_609603.1	S_TKc	45..328	CDD:214567	120/285 (42%)
GSK3A	NP_063937.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..96
		STKc_GSK3	114..406	CDD:271039	125/300 (42%)
		Pkinase	119..403	CDD:278497	122/292 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	449..483
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	42	1.000	Domainoid score	I12443
eggNOG	1	0.900	-	-		E2759_KOG0658
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S376
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D990896at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.730