DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pk34A and Cdk12

DIOPT Version :10

Sequence 1:NP_609603.1 Gene:Pk34A / 34705 FlyBaseID:FBgn0028410 Length:392 Species:Drosophila melanogaster
Sequence 2:NP_001029039.1 Gene:Cdk12 / 192350 RGDID:621111 Length:1484 Species:Rattus norvegicus


Alignment Length:411 Identity:104/411 - (25%)
Similarity:182/411 - (44%) Gaps:84/411 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 QKPLKRHAQV--PLIIPKNSVISTYAVGRLCSEPALVRIEVKDLIGSGSFGRVYQAHVNESEEIV 70
            |:|.|:..::  |....:....|.:  |:.|.:    :.::..:||.|::|:||:|...::.|:|
  Rat   691 QQPYKKRPKICCPRYGERRQTESDW--GKRCVD----KFDIIGIIGEGTYGQVYKAKDKDTGELV 749

  Fly    71 AVKQT-LYNPKLSQG-------EAEIMGQLKDHNNIVRLIMHSSVSLGFPSVDY------VLLVM 121
            |:|:. |.|.|  :|       |.:|:.||. |.::|.  |...|:....::|:      ..||.
  Rat   750 ALKKVRLDNEK--EGFPITAIREIKILRQLV-HQSVVN--MKEIVTDKQDALDFKKDKGAFYLVF 809

  Fly   122 EYMPMTLLDYINYHLTVLQPAERLINVRILSYQMFRGLGYLHLLGISHRDVKPENLLIDNQKMVL 186
            |||...|:..:...|......    :::....|:..||.|.|.....|||:|..|:|::|...: 
  Rat   810 EYMDHDLMGLLESGLVHFSED----HIKSFMKQLMEGLDYCHKKNFLHRDIKCSNILLNNSGQI- 869

  Fly   187 KLSDFGSAKLLVPQE--PSISYICSRLYRAPELFAGYELYSCAVDIWSAGCVLAELLKGYPLFSS 249
            ||:|||.|:|...:|  |..:.:.:..||.|||..|.|.|:.|:|:||.||:|.||....|:|.:
  Rat   870 KLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQA 934

  Fly   250 HKHDRKQLRLIVNMLGTDGLERAPEILS-KCGNSLHP-----RTTRPSWNYLLNTAV-------- 300
            :. :..||.||..:.|:......|:::. ...|::.|     |..|..::::.:.|:        
  Rat   935 NL-ELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLT 998

  Fly   301 --PQDLC---GLLNSCFIYEA-AARISP-----MMACSHGSYDELR------------------- 335
              |...|   ..|.|.|:.:. .::::|     ...| |..:.:.|                   
  Rat   999 LDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDC-HELWSKKRRRQRQSGIVIEEQPPSKAS 1062

  Fly   336 ----IMDAMALPMPNGNPLPP 352
                .....|.|:.|.:|.||
  Rat  1063 RKETTSGTAAEPVKNSSPAPP 1083

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pk34ANP_609603.1 STKc_GSK3 39..334 CDD:271039 90/335 (27%)
Cdk12NP_001029039.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..462
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 485..603
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 616..699 3/7 (43%)
STKc_CDK12 715..1016 CDD:270847 88/317 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1046..1101 6/38 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1156..1199
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1218..1356
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1437..1484
Blue background indicates that the domain is not in the aligned region.

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