DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ttc30 and flr

DIOPT Version :9

Sequence 1:	NP_001097155.2	Gene:	Ttc30 / 34702	FlyBaseID:	FBgn0032470	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_021327391.1	Gene:	flr / 797829	ZFINID:	ZDB-GENE-070117-2066	Length:	667	Species:	Danio rerio

Alignment Length:	672	Identity:	300/672 - (44%)
Similarity:	424/672 - (63%)	Gaps:	37/672 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LREGHVTRTIYNLIKDKRYEDVIECIT-SFGEAANTRAGLSTLGHCYYHAQKYEEAATCYEQLCQ 71
            :::|..|.|:|.:||:.||.|.|..:: ...:...:||.||.||:||||.|.:..||.|||||.|
Zfish     6 IKDGEYTATVYKMIKEGRYGDAIHILSKEHQKHTKSRAALSLLGYCYYHMQDFTNAAECYEQLTQ 70

  Fly    72 LAPKEAKYRFYYAQSLYQAGIFADALRVLKQMGDQEDELREQCLQLQSAILYSSEDFAGAQSLLN 136
            |.|:...|:.|||||||.|..|.:|::....:.:.....:  .::||:||.|..||::||::|:.
Zfish    71 LHPEVEDYKLYYAQSLYGACAFPEAMKSTFLLDNTTSHTK--MIKLQAAIKYGEEDYSGAKTLVE 133

  Fly   137 QRAGGTADTLNDEGCLLFQADQHEAAVQRFQAALQVGGFNPLVAYNVALAHFQKKQRAQALDYTS 201
            |......|...|.||||::..:.|.|.::|.:::.|.|:.|.:|||:||.::..||.|.||.|.:
Zfish   134 QLPQEDPDYDVDLGCLLYKEGEFEEACKKFMSSMNVLGYQPDLAYNIALCYYSLKQYASALKYIA 198

  Fly   202 EIVERGMRNHPELGIGAQMDIPDGGARSVGNPITMAISGITQALNLKAAIEFQDGNEEAARDALL 266
            ||:|||:|.||||.||...:..|  .|||||.:.:..:.:.:|.|||||||:|..|..||::||.
Zfish   199 EIIERGIREHPELSIGMTTEGID--VRSVGNTLILHETALIEAFNLKAAIEYQLKNYAAAQEALT 261

  Fly   267 DLPPRAESELDPVTLHNMALTDVE-GPVAGLRKLAFLLELGAPSCPKETFANILLICCKNELYET 330
            |:|||:|.|||||||||.||.::: .|..|..||||||:..  ..|..||.|:||:.||.|.::.
Zfish   262 DMPPRSEEELDPVTLHNQALMNMDTKPTEGFEKLAFLLQQN--PFPPVTFGNLLLLYCKYEYFDL 324

  Fly   331 AADILAEHTDLTYKYLSQYLYELLDSLITAQTSAELAEKKLGTLASSLAGKLRSLAAKVQEVRAT 395
            |||:|||:..||||:|:.||||.||::||.||:.|.|.:|....|..|..:||.:..:|||.|..
Zfish   325 AADVLAENAHLTYKFLTPYLYEFLDAMITCQTAPEEAFRKFDENAGKLTEQLRKVTKQVQEARHN 389

  Fly   396 NEQQALRDALKDYEQALELYLPVVMARAWISWRDDDFVGAEREFHASAEFCSENSIWRLNAGHVL 460
            .:.::|:..::||::.||.|:||:||:|.|.|..:::...|:.||.|.|||:|:..|:||..|||
Zfish   390 RDDESLKKYVQDYDEVLEKYIPVLMAQAKIYWNRENYSMVEKIFHKSLEFCNEHDTWKLNVAHVL 454

  Fly   461 FMQGDKYNEAAAFYEPIVRQHSDD----------------IMSVSAAVLANLCVSYIMTFQNEEA 509
            |||.:||.||..||||||::|.::                |::|||.||||||||||||.|||||
Zfish   455 FMQDNKYKEAIGFYEPIVKKHYENLEQCNIQECPCKTKPSILNVSAIVLANLCVSYIMTSQNEEA 519

  Fly   510 EELMRKVEKAEEM--KGNLGKQYHHLCIVNLVVGTLYCAKSNYEFGLSRIAHALESGSGNRLYAD 572
            ||||||:||.||.  ..:..|:..||||||||:|||||||.||:||:||:..:||. ...:|..|
Zfish   520 EELMRKIEKEEEQISYDDPDKKIFHLCIVNLVIGTLYCAKGNYDFGISRVIKSLEP-YNKKLGTD 583

  Fly   573 TWLHVKHCILGLLTGMAKQNIILPYATVQEVLNFLRFCESYGLFTPANIFSATEQVPEEPL---- 633
            ||.:.|.|.|.||..|||..|:|..:.|||.:.||..||.||    .::.:..||..||..
Zfish   584 TWFYAKRCFLSLLENMAKHMIMLRDSVVQECIQFLEHCELYG----KDVLAIIEQPLEEDRMHIG 644

  Fly   634 --TIGLEARKLRLLLIKLSEYD 653
              |:..|:|.::.|..:::.::
Zfish   645 KNTVTYESRLIKALFYEVTGWN 666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ttc30	NP_001097155.2	TPR_2	45..75	CDD:285020	18/29 (62%)
		TPR repeat	46..71	CDD:276809	16/24 (67%)
		TPR_11	49..102	CDD:290150	28/52 (54%)
		TPR repeat	76..117	CDD:276809	11/40 (28%)
		TPR repeat	129..171	CDD:276809	13/41 (32%)
		TPR_11	143..205	CDD:290150	25/61 (41%)
		TPR repeat	176..205	CDD:276809	14/28 (50%)
flr	XP_021327391.1	TPR_11	21..>203	CDD:330823	72/183 (39%)
		TPR repeat	41..71	CDD:276809	18/29 (62%)
		TPR repeat	113..137	CDD:276809	11/23 (48%)
		TPR repeat	173..202	CDD:276809	14/28 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576354
Domainoid	1	1.000	407	1.000	Domainoid score	I671
eggNOG	1	0.900	-	-		E1_KOG4340
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H71716
Inparanoid	1	1.050	557	1.000	Inparanoid score	I1070
OMA	1	1.010	-	-		QHG56317
OrthoDB	1	1.010	-	-		D219475at33208
OrthoFinder	1	1.000	-	-		FOG0004420
OrthoInspector	1	1.000	-	-		oto40559
orthoMCL	1	0.900	-	-		OOG6_103666
Panther	1	1.100	-	-	LDO	PTHR20931
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2861
SonicParanoid	1	1.000	-	-		X3134
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800