Protein Alignment Ttc30 and ift70

DIOPT Version :10

• Sequence 1: NP_001097155.2
• Gene: Ttc30 / 34702
• FlyBaseID: FBgn0032470
• Length: 655
• Species: Drosophila melanogaster
• Sequence 2: XP_021327391.1
• Gene: ift70 / 797829
• ZFINID: ZDB-GENE-070117-2066
• Length: 667
• Species: Danio rerio
• Alignment Length: 672
• Identity: 300/672 - (44%)
• Similarity: 424/672 - (63%)
• Gaps: 37/672 - (5%)

  Fly     8 LREGHVTRTIYNLIKDKRYEDVIECIT-SFGEAANTRAGLSTLGHCYYHAQKYEEAATCYEQLCQ 71
            :::|..|.|:|.:||:.||.|.|..:: ...:...:||.||.||:||||.|.:..||.|||||.|
Zfish     6 IKDGEYTATVYKMIKEGRYGDAIHILSKEHQKHTKSRAALSLLGYCYYHMQDFTNAAECYEQLTQ 70

  Fly    72 LAPKEAKYRFYYAQSLYQAGIFADALRVLKQMGDQEDELREQCLQLQSAILYSSEDFAGAQSLLN 136
            |.|:...|:.|||||||.|..|.:|::....:.:.....:  .::||:||.|..||::||::|:.
Zfish    71 LHPEVEDYKLYYAQSLYGACAFPEAMKSTFLLDNTTSHTK--MIKLQAAIKYGEEDYSGAKTLVE 133

  Fly   137 QRAGGTADTLNDEGCLLFQADQHEAAVQRFQAALQVGGFNPLVAYNVALAHFQKKQRAQALDYTS 201
            |......|...|.||||::..:.|.|.::|.:::.|.|:.|.:|||:||.::..||.|.||.|.:
Zfish   134 QLPQEDPDYDVDLGCLLYKEGEFEEACKKFMSSMNVLGYQPDLAYNIALCYYSLKQYASALKYIA 198

  Fly   202 EIVERGMRNHPELGIGAQMDIPDGGARSVGNPITMAISGITQALNLKAAIEFQDGNEEAARDALL 266
            ||:|||:|.||||.||...:..|  .|||||.:.:..:.:.:|.|||||||:|..|..||::||.
Zfish   199 EIIERGIREHPELSIGMTTEGID--VRSVGNTLILHETALIEAFNLKAAIEYQLKNYAAAQEALT 261

  Fly   267 DLPPRAESELDPVTLHNMALTDVE-GPVAGLRKLAFLLELGAPSCPKETFANILLICCKNELYET 330
            |:|||:|.|||||||||.||.::: .|..|..||||||:..  ..|..||.|:||:.||.|.::.
Zfish   262 DMPPRSEEELDPVTLHNQALMNMDTKPTEGFEKLAFLLQQN--PFPPVTFGNLLLLYCKYEYFDL 324

  Fly   331 AADILAEHTDLTYKYLSQYLYELLDSLITAQTSAELAEKKLGTLASSLAGKLRSLAAKVQEVRAT 395
            |||:|||:..||||:|:.||||.||::||.||:.|.|.:|....|..|..:||.:..:|||.|..
Zfish   325 AADVLAENAHLTYKFLTPYLYEFLDAMITCQTAPEEAFRKFDENAGKLTEQLRKVTKQVQEARHN 389

  Fly   396 NEQQALRDALKDYEQALELYLPVVMARAWISWRDDDFVGAEREFHASAEFCSENSIWRLNAGHVL 460
            .:.::|:..::||::.||.|:||:||:|.|.|..:::...|:.||.|.|||:|:..|:||..|||
Zfish   390 RDDESLKKYVQDYDEVLEKYIPVLMAQAKIYWNRENYSMVEKIFHKSLEFCNEHDTWKLNVAHVL 454

  Fly   461 FMQGDKYNEAAAFYEPIVRQHSDD----------------IMSVSAAVLANLCVSYIMTFQNEEA 509
            |||.:||.||..||||||::|.::                |::|||.||||||||||||.|||||
Zfish   455 FMQDNKYKEAIGFYEPIVKKHYENLEQCNIQECPCKTKPSILNVSAIVLANLCVSYIMTSQNEEA 519

  Fly   510 EELMRKVEKAEEM--KGNLGKQYHHLCIVNLVVGTLYCAKSNYEFGLSRIAHALESGSGNRLYAD 572
            ||||||:||.||.  ..:..|:..||||||||:|||||||.||:||:||:..:||. ...:|..|
Zfish   520 EELMRKIEKEEEQISYDDPDKKIFHLCIVNLVIGTLYCAKGNYDFGISRVIKSLEP-YNKKLGTD 583

  Fly   573 TWLHVKHCILGLLTGMAKQNIILPYATVQEVLNFLRFCESYGLFTPANIFSATEQVPEEPL---- 633
            ||.:.|.|.|.||..|||..|:|..:.|||.:.||..||.||    .::.:..||..||..
Zfish   584 TWFYAKRCFLSLLENMAKHMIMLRDSVVQECIQFLEHCELYG----KDVLAIIEQPLEEDRMHIG 644

  Fly   634 --TIGLEARKLRLLLIKLSEYD 653
              |:..|:|.::.|..:::.::
Zfish   645 KNTVTYESRLIKALFYEVTGWN 666

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ttc30	NP_001097155.2	LapB	46..>206	CDD:442196	66/159 (42%)
		TPR repeat	46..71	CDD:276809	16/24 (67%)
		TPR repeat	76..117	CDD:276809	11/40 (28%)
		TPR repeat	129..171	CDD:276809	13/41 (32%)
		TPR repeat	176..205	CDD:276809	14/28 (50%)
		Spy	316..>515	CDD:443119	104/214 (49%)
ift70	XP_021327391.1	LapB	<19..203	CDD:442196	74/185 (40%)
		TPR repeat	41..71	CDD:276809	18/29 (62%)
		TPR repeat	113..137	CDD:276809	11/23 (48%)
		TPR repeat	173..202	CDD:276809	14/28 (50%)
		BepA	400..>480	CDD:443813	40/79 (51%)