DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ttc30 and Ttc30a1

DIOPT Version :9

Sequence 1:NP_001097155.2 Gene:Ttc30 / 34702 FlyBaseID:FBgn0032470 Length:655 Species:Drosophila melanogaster
Sequence 2:NP_084464.3 Gene:Ttc30a1 / 78802 MGIID:1926052 Length:664 Species:Mus musculus


Alignment Length:664 Identity:306/664 - (46%)
Similarity:430/664 - (64%) Gaps:39/664 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 EGHVTRTIYNLIKDKRYEDVIECITS-FGEAANTRAGLSTLGHCYYHAQKYEEAATCYEQLCQLA 73
            :|..|..:|.||:|.||.:.::.::: ...::.:|||||.|.:|||..|::|.||.|||||.|:.
Mouse    11 DGEFTAVVYRLIRDSRYSEAVQLLSAELQRSSRSRAGLSLLAYCYYRLQEFELAAECYEQLSQMH 75

  Fly    74 PKEAKYRFYYAQSLYQAGIFADALRVLKQMGDQEDELREQCLQLQSAILYSSEDFAGAQSLLNQR 138
            |:..:||.|.||:||:|.::.:|.||...:.:...:.|  .|:||:||.||..|..||:||:.|.
Mouse    76 PELEQYRLYQAQALYKACLYPEATRVTFLLDNPAYQTR--VLRLQAAIKYSEGDLPGARSLVEQL 138

  Fly   139 AGGTA----------DTLNDEGCLLFQADQHEAAVQRFQAALQVGGFNPLVAYNVALAHFQKKQR 193
            ..|.|          |.|.:.||||::...:|||..:|.||||..|:.|.::||:|||::..:|.
Mouse   139 LSGEAGEDSGGENDPDGLVNMGCLLYKEGHYEAACSKFLAALQASGYQPDLSYNLALAYYSSRQY 203

  Fly   194 AQALDYTSEIVERGMRNHPELGIGAQMDIPDGGARSVGNPITMAISGITQALNLKAAIEFQDGNE 258
            |.||.:.::|:|||:|.|||||:|...:..|  .|||||.:.:..:.:.:|.|||||||:|..|.
Mouse   204 APALKHIADIIERGIRQHPELGVGMTTEGID--VRSVGNTVVLHQTALIEAFNLKAAIEYQLRNF 266

  Fly   259 EAARDALLDLPPRAESELDPVTLHNMALTDVEG-PVAGLRKLAFLLELGAPSCPKETFANILLIC 322
            |.|::.|.|:|||||.|||||||||.||.:::. |..|..||.|||:..  ..|.|||.|:||:.
Mouse   267 EVAQETLTDMPPRAEEELDPVTLHNQALMNMDAKPTEGFEKLQFLLQQN--PFPPETFGNLLLLY 329

  Fly   323 CKNELYETAADILAEHTDLTYKYLSQYLYELLDSLITAQTSAELAEKKLGTLASSLAGKLRSLAA 387
            ||.|.::.|||:|||:..||||:|:.|||:.||::||.||:.|.|..||..||..|..:||.|..
Mouse   330 CKYEYFDLAADVLAENAHLTYKFLTPYLYDFLDAMITCQTAPEEAFIKLDGLAGMLTEQLRRLTK 394

  Fly   388 KVQEVRATNEQQALRDALKDYEQALELYLPVVMARAWISWRDDDFVGAEREFHASAEFCSENSIW 452
            :|||.|...:.:.::.|:.:|::.||.|:||:||:|.|.|..:::...|:.|..|.|||:::.:|
Mouse   395 QVQEARHNRDDEIIKKAMNEYDETLEKYIPVLMAQAKIYWNLENYPMVEKIFRKSVEFCNDHDVW 459

  Fly   453 RLNAGHVLFMQGDKYNEAAAFYEPIVRQHSDDIMSVSAAVLANLCVSYIMTFQNEEAEELMRKVE 517
            :||..||||||.:||.||..||||||:::.|:|:||||.||||||||||||.|||||||||||:|
Mouse   460 KLNVAHVLFMQENKYKEAIGFYEPIVKKNYDNILSVSAIVLANLCVSYIMTSQNEEAEELMRKIE 524

  Fly   518 KAEEM--KGNLGKQYHHLCIVNLVVGTLYCAKSNYEFGLSRIAHALESGSGNRLYADTWLHVKHC 580
            |.||.  .|:..|:.:||||||||:|||||||.||:||:||:..:||. ...:|..|||.:.|.|
Mouse   525 KEEEQLSYGDPDKKIYHLCIVNLVIGTLYCAKGNYDFGISRVIKSLEP-YHKKLGTDTWYYAKRC 588

  Fly   581 ILGLLTGMAKQNIILPYATVQEVLNFLRFCESYGLFTPANIFSATEQVPEEPL----------TI 635
            .|.||..|:|..|:|....|||.:.||.:||.||...||        |.|:||          |:
Mouse   589 FLSLLENMSKHMIVLCDGVVQECVQFLEYCELYGRNIPA--------VLEQPLEEERIHTGKNTV 645

  Fly   636 GLEARKLRLLLIKL 649
            ..|:|.|:.|:.::
Mouse   646 TYESRLLKALIYEV 659

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ttc30NP_001097155.2 TPR_2 45..75 CDD:285020 17/29 (59%)
TPR repeat 46..71 CDD:276809 15/24 (63%)
TPR_11 49..102 CDD:290150 26/52 (50%)
TPR repeat 76..117 CDD:276809 13/40 (33%)
TPR repeat 129..171 CDD:276809 19/51 (37%)
TPR_11 143..205 CDD:290150 27/71 (38%)
TPR repeat 176..205 CDD:276809 11/28 (39%)
Ttc30a1NP_084464.3 TPR 1 11..44 8/32 (25%)
TPR_19 21..87 CDD:291240 28/65 (43%)
TPR repeat 44..74 CDD:276809 18/29 (62%)
TPR 2 45..78 20/32 (63%)
TPR repeat 113..140 CDD:276809 14/28 (50%)
TPR_11 152..215 CDD:290150 26/62 (42%)
TPR 3 153..186 15/32 (47%)
TPR repeat 153..181 CDD:276809 12/27 (44%)
TPR 4 188..220 13/31 (42%)
TPR 5 393..423 8/29 (28%)
TPR 6 424..456 13/31 (42%)
TPR repeat 425..451 CDD:276809 9/25 (36%)
TPR repeat 456..487 CDD:276809 19/30 (63%)
TPR 7 458..491 19/32 (59%)
TPR_19 468..529 CDD:291240 45/60 (75%)
TPR repeat 497..522 CDD:276809 22/24 (92%)
TPR 8 543..576 21/33 (64%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167833638
Domainoid 1 1.000 422 1.000 Domainoid score I631
eggNOG 1 0.900 - - E1_KOG4340
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 566 1.000 Inparanoid score I1072
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG56317
OrthoDB 1 1.010 - - D219475at33208
OrthoFinder 1 1.000 - - FOG0004420
OrthoInspector 1 1.000 - - otm42491
orthoMCL 1 0.900 - - OOG6_103666
Panther 1 1.100 - - O PTHR20931
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X3134
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1413.770

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