DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ttc30 and dyf-1

DIOPT Version :9

Sequence 1:	NP_001097155.2	Gene:	Ttc30 / 34702	FlyBaseID:	FBgn0032470	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_491494.2	Gene:	dyf-1 / 172122	WormBaseID:	WBGene00001117	Length:	656	Species:	Caenorhabditis elegans

Alignment Length:	659	Identity:	244/659 - (37%)
Similarity:	386/659 - (58%)	Gaps:	33/659 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LREGHVTRTIYNLIKDKRYEDVIECITSFGEAANTR--AGLSTLGHCYYHAQKYEEAATCYEQLC 70
            ::||..|.|||.||.:.::.|.|. |..:....|.:  |.||.|.:|||:.|.:..||.||.||.
Worm     7 IKEGEFTSTIYTLIHEHKFNDAIR-ILQYQHERNPKNLAALSLLAYCYYYTQDFMNAADCYSQLS 70

  Fly    71 QLAPKEAKYRFYYAQSLYQAGIFADALRVLKQMGDQEDELREQCLQLQSAILYSSEDFAGAQSLL 135
            ...|:.::|:.|:|||||.|...||||.|:..:  |::.|..:.::|::||.|..:|....:.|:
Worm    71 YNFPQYSQYKLYHAQSLYNAFRPADALAVVSMI--QDENLLNESVKLEAAIKYQEDDLVNCRILV 133

  Fly   136 NQRAGGTADTLNDEGCLLFQADQHEAAVQRFQAALQVGGFNPLVAYNVALAHFQKKQRAQALDYT 200
            .|.....|..:.:..|:.::...:|.|:::|..|.:..|:...:||::||.|:::.....||...
Worm   134 EQLPENDAAVIINTACIDYKEGNYEEALKKFNEATEFSGYQSGLAYSIALCHYRRGDYDSALKLI 198

  Fly   201 SEIVERGMRNHPELGIGAQMDIPDG-GARSVGNPITMAISGITQALNLKAAIEFQDGNEEAARDA 264
            |||:.||:::|||..||.   :.:| ....:.|...:..|.:.:|.|||.||.::..:.:||:::
Worm   199 SEIINRGVKDHPEFNIGM---VTEGIDVNFIQNTQKLHESALIEAFNLKFAIYYRTKDFKAAKES 260

  Fly   265 LLDLPPRAESELDPVTLHNMALTDVEGPVA-GLRKLAFLLELGAPSCPKETFANILLICCKNELY 328
            |.|:|||.|.:.||:||||:|:::...... ...||.||  ||....|:|||||:|.:.|||:.:
Worm   261 LTDMPPRNEHDADPITLHNLAISNANSDFGDSSAKLQFL--LGINPFPQETFANLLFLYCKNDYF 323

  Fly   329 ETAADILAEHTDLTYKYLSQYLYELLDSLITAQTSAELAEKKLGTLASSLAGKLRSLAAKVQ--- 390
            ..|||:|||:...|:..|::|.:.||::||...|:.|.:.|||..|......:||..|.::|
Worm   324 GLAADVLAENPSHTFYCLNEYQFNLLEALIYMPTNPEESLKKLEKLEKECLDRLRKTAIEIQIKK 388

  Fly   391 EVRATNEQQAL--RDALKDYEQALELYLPVVMARAWISWRDDDFVGAEREFHASAEFCSENSIWR 453
            |.:.|:...:|  |:.::.|:.:||:||||:|..|...|...|:...|:.|..|.::|.|:..|:
Worm   389 EQKTTDSDDSLEMRNLIESYDDSLEMYLPVLMTYAKYYWDKRDYQAVEKLFRNSVDYCKEHDTWK 453

  Fly   454 LNAGHVLFMQGDKYNEAAAFYEPIV-RQHSDDIMSVSAAVLANLCVSYIMTFQNEEAEELMRKVE 517
            ||..|.:|||..||.:||||||||| :::.|.|:.|.|.:||||.|.||||.|.:|||.:::.||
Worm   454 LNVAHTIFMQEKKYKDAAAFYEPIVHKKYDDGILEVPAMILANLVVCYIMTNQTDEAELILKAVE 518

  Fly   518 KAEE----MKGNLGKQYHHLCIVNLVVGTLYCAKSNYEFGLSRIAHALESGSGNRLYADTWLHVK 578
            ..||    ||.|  :::.|..|::||:|:|||:|.|:|||:||:..|||... .:|..|||.:.|
Worm   519 NEEEAALMMKPN--EKFFHNSIISLVIGSLYCSKGNFEFGISRVVKALEPPE-KKLGVDTWYYAK 580

  Fly   579 HCILGLLTGMAKQNIILPYATVQEVLNFLRFCESYG--LFT-PANIFSATEQVPEEPL--TIGLE 638
            .||:..:..|||..:::..:.|.||:.||..||..|  ::| |.::|   ||..|..:  .:..|
Worm   581 RCIVAAIELMAKNLLVMRDSVVMEVIQFLTSCEVPGRNIYTVPDDLF---EQAGESKVKCNVTYE 642

  Fly   639 ARKLRLLLI 647
            ||.::..|:
Worm   643 ARMIKAALL 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ttc30	NP_001097155.2	TPR_2	45..75	CDD:285020	13/29 (45%)
		TPR repeat	46..71	CDD:276809	13/24 (54%)
		TPR_11	49..102	CDD:290150	25/52 (48%)
		TPR repeat	76..117	CDD:276809	15/40 (38%)
		TPR repeat	129..171	CDD:276809	8/41 (20%)
		TPR_11	143..205	CDD:290150	17/61 (28%)
		TPR repeat	176..205	CDD:276809	10/28 (36%)
dyf-1	NP_491494.2	TPR_19	19..85	CDD:291240	23/66 (35%)
		TPR_11	140..203	CDD:290150	17/62 (27%)
		TPR repeat	141..169	CDD:276809	6/27 (22%)
		TPR repeat	174..233	CDD:276809	19/61 (31%)
		TPR repeat	238..261	CDD:276809	8/22 (36%)
		TPR_19	461..>521	CDD:291240	33/59 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157586
Domainoid	1	1.000	300	1.000	Domainoid score	I773
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H71716
Inparanoid	1	1.050	416	1.000	Inparanoid score	I1023
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56317
OrthoDB	1	1.010	-	-		D219475at33208
OrthoFinder	1	1.000	-	-		FOG0004420
OrthoInspector	1	1.000	-	-		oto19125
orthoMCL	1	0.900	-	-		OOG6_103666
Panther	1	1.100	-	-	LDO	PTHR20931
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2861
SonicParanoid	1	1.000	-	-		X3134
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.940