DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9932 and ZNF335

DIOPT Version :9

Sequence 1:	NP_609599.1	Gene:	CG9932 / 34701	FlyBaseID:	FBgn0262160	Length:	2171	Species:	Drosophila melanogaster
Sequence 2:	NP_071378.1	Gene:	ZNF335 / 63925	HGNCID:	15807	Length:	1342	Species:	Homo sapiens

Alignment Length:	1286	Identity:	238/1286 - (18%)
Similarity:	393/1286 - (30%)	Gaps:	456/1286 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 EKIVIN--KCKLCLYASRHFQKLVRHMKMVHGCTDGIPSGHGQARGKRGMSRE---ARKRRLEES 202
            |.:|:.  |||:|.|.|.....|:|||:..|...   .:....|.||:|..|:   :.|.:.||.
Human   238 EVVVVQQFKCKMCQYRSSTKATLLRHMRERHFRP---VAAAAAAAGKKGRLRKWSTSTKSQEEEG 299

  Fly   203 VGVMGGQSLTVTVPDVPTLEQ------VKRELLLQEEKLQRDIQAFNQRQREEQQREQQRELELV 261
            ........: |....:..||:      .:.|...::.:|||...:..:.:|...:..:...||:.
Human   300 PEEEDDDDI-VDAGAIDDLEEDSDYNPAEDEPRGRQLRLQRPTPSTPRPRRRPGRPRKLPRLEIS 363

  Fly   262 ATSAYERQMQVLRDYERQSPAEPPTP-SPTSG-----------SATP--------------PSNG 300
            ..........::.....|||.||..| :|:|.           |.||              ||..
Human   364 DLPDGVEGEPLVSSQSGQSPPEPQDPEAPSSSGPGHLVAMGKVSRTPVEAGVSQSDAENAAPSCP 428

  Fly   301 EE----PQNR------------------------------------------------------- 306
            :|    |:.|
Human   429 DEHDTLPRRRGRPSRRFLGKKYRKYYYKSPKPLLRPFLCRICGSRFLSHEDLRFHVNSHEAGDPQ 493

  Fly   307 LLKCSACEFTTLYRTQLRAHELAEHGKTKFFRCDKCSYVTHIKARFSKHVKYHS----------- 360
            |.||..|.:.:...:.|:.| :..|..:|.::||:|||.:..:....:|...||
Human   494 LFKCLQCSYRSRRWSSLKEH-MFNHVGSKPYKCDECSYTSVYRKDVIRHAAVHSRDRKKRPDPTP 557

  Fly   361 -MPMIKCVTCDFRTPYKWNLDRHMKNHG-------------------------------GAGAFK 393
             :....|..|....|.:..|.:|||.|.                               ....||
Human   558 KLSSFPCPVCGRVYPMQKRLTQHMKTHSTEKPHMCDKCGKSFKKRYTFKMHLLTHIQAVANRRFK 622

  Fly   394 CAACDFTADIKQSLTVHEMNHHVPPVGNAGSIWPRRQNKVGASEMCEDFLSDSAELED------- 451
            |..|:|..:.|::|..|::: ||.......|..|.|..:       ||||.....::.
Human   623 CEFCEFVCEDKKALLNHQLS-HVSDKPFKCSFCPYRTFR-------EDFLLSHVAVKHTGAKPFA 679

  Fly   452 -QYNNNNVDDELDGVDDADEAMSGGEEQPLHLH----------HYGKRSKYDDEEEPT------- 498
             :|.:                .|...::.|.||          .:|:|   ..||.|:
Human   680 CEYCH----------------FSTRHKKNLRLHVRCRHASSFEEWGRR---HPEEPPSRRRPFFS 725

  Fly   499 -----DLSQKGGCS--SDTSSVGTPTPRAQRT------MPNL----------IPISKGAKD---- 536
                 :|.|:...:  ...||.|.|....:.|      .|:|          |...:||::
Human   726 LQQIEELKQQHSAAPGPPPSSPGPPEIPPEATTFQSSEAPSLLCSDTLGGATIIYQQGAEESTAM 790

  Fly   537 --------VLNLSKETNASRSSLTEIASMFFNEKQISEMLDKSDVPQ--LSPATTVASQNSTRSQ 591
                    :||:|.:.....::|           |:: ::...||..  .||....:.:.:|...
Human   791 ATQTALDLLLNMSAQRELGGTAL-----------QVA-VVKSEDVEAGLASPGGQPSPEGATPQV 843

  Fly   592 LTKKSSFMDKLKTGAQHENLVCQCGHVAKCLSE---------------------SII------HG 629
            :|..                |.:.|..|...|:                     |:|      .|
Human   844 VTLH----------------VAEPGGGAAAESQLGPPDLPQITLAPGPFGGTGYSVITAPPMEEG 892

  Fly   630 KSC------------HASAVIIDE--DEAGLHEDDGDDRLEIDEDDEDHHSHSALNLSVTGSTRC 680
            .|.            .|.||::.:  .|||.|.....|..::      ||    :.|:..||...
Human   893 TSAPGTPYSEEPAGEAAQAVVVSDTLKEAGTHYIMATDGTQL------HH----IELTADGSISF 947

  Fly   681 QHCRHRCKSSTDLMHH-----LKQCVEAIRCANEMYDSNSGESGDRRP---------DSQSLQQQ 731
                    .|.|.:..     |.||            ......|...|         ||||....
Human   948 --------PSPDALASGAKWPLLQC------------GGLPRDGPEPPSPAKTHCVGDSQSSASS 992

  Fly   732 AAVQQQRVCIWNKATKEIIAAAAASLQQDKNNHNLVKSPTGSQAASNEENSYYGVETAPGYGEVT 796
            .           .||.:.:..|...           ..|:.:.|||.:.:.....|..||..|:
Human   993 P-----------PATSKALGLAVPP-----------SPPSAATAASKKFSCKICAEAFPGRAEM- 1034

  Fly   797 KKMTPEEEAANSSLKKVYKCPHCSFWASTASRFHVHIVGHLNKKPFECSLCSYRSNWRWDITKHI 861
                 |......:....:|||.|.|.|........|:..|.:.:|.:||.||:.|..:.|:.:|:
Human  1035 -----ESHKRAHAGPGAFKCPDCPFSARQWPEVRAHMAQHSSLRPHQCSQCSFASKNKKDLRRHM 1094

  Fly   862 RLKTIRDPSHKTAKVLMNDETGRRNYTKYNKYITLMKVTEEDGDPKLMKSGEMT---PNQVASLA 923
            ...|...|   .|..|......|..:.|::    :.::...||    .|||..|   |.|..:..
Human  1095 LTHTKEKP---FACHLCGQRFNRNGHLKFH----IQRLHSPDG----RKSGTPTARAPTQTPTQT 1148

  Fly   924 FLKDYAKVGSVSGQDITLEPVLPNKPNVLDDAHLADNLIRIPLLATMMNAAMAQQQHQQQQQKEH 988
            .:        ::..|.||..:    ...|..:|                ..:..::.||...:||
Human  1149 II--------LNSDDETLATL----HTALQSSH----------------GVLGPERLQQALSQEH 1185

  Fly   989 QSTMITPSVTISPVKRSNQASVMQGKPSDDLITEVHQEGNEKRTVYRCRKCNFGHQNRDAVLAHV 1053
              .::....|::   ...:|:.:|...:.|..|..|...::.:..|..        ::|.|.
Human  1186 --IIVAQEQTVT---NQEEAAYIQEITTADGQTVQHLVTSDNQVQYII--------SQDGVQ--- 1234

  Fly  1054 KIHYQDASYPKSNSGNSSTSPLQVSVGGSPQFYMNKVFAAMCLSQTQSQSSPNSGSAGTSPAISA 1118
              |.....|.....|:.    :||..|........:  .|..|.::|.|..|          :|.
Human  1235 --HLLPQEYVVVPEGHH----IQVQEGQITHIQYEQ--GAPFLQESQIQYVP----------VSP 1281

  Fly  1119 G---LLQRAIQEAQHSPTPNASALSGLALALAGGKPQANTTKASAASILEH 1166
            |   :.|..::.|.||.   .:|::..|:|.|.|....:.|.......|:|
Human  1282 GQQLVTQAQLEAAAHSA---VTAVADAAMAQAQGLFGTDETVPEHIQQLQH 1329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9932	NP_609599.1	C2H2 Zn finger	339..359	CDD:275368	6/19 (32%)
		C2H2 Zn finger	366..386	CDD:275368	7/19 (37%)
		C2H2 Zn finger	394..414	CDD:275368	6/19 (32%)
		C2H2 Zn finger	816..836	CDD:275370	6/19 (32%)
		C2H2 Zn finger	844..862	CDD:275370	7/17 (41%)
ZNF335	NP_071378.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..102
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..228
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	274..442		34/168 (20%)
		C2H2 Zn finger	467..487	CDD:275368	0/19 (0%)
		C2H2 Zn finger	497..517	CDD:275368	4/20 (20%)
		zf-H2C2_2	509..534	CDD:290200	9/25 (36%)
		C2H2 Zn finger	529..545	CDD:275370	3/15 (20%)
		C2H2 Zn finger	564..584	CDD:275368	7/19 (37%)
		zf-H2C2_2	577..600	CDD:290200	5/22 (23%)
		zf-C2H2	590..612	CDD:278523	0/21 (0%)
		C2H2 Zn finger	592..612	CDD:275368	0/19 (0%)
		C2H2 Zn finger	623..643	CDD:275368	6/20 (30%)
		C2H2 Zn finger	651..672	CDD:275368	7/27 (26%)
		C2H2 Zn finger	680..699	CDD:275368	5/34 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	732..763		7/30 (23%)
		PRK04654	<795..911	CDD:135173	20/143 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	964..1013		11/82 (13%)
		C2H2 Zn finger	1021..1041	CDD:275368	5/25 (20%)
		Involved in the interaction with CCAR2. /evidence=ECO:0000269\|PubMed:19131338	1041..1342		73/365 (20%)
		C2H2 Zn finger	1049..1069	CDD:275368	6/19 (32%)
		zf-H2C2_5	1075..1097	CDD:290620	7/21 (33%)
		C2H2 Zn finger	1077..1097	CDD:275368	7/19 (37%)
		zf-H2C2_2	1089..1114	CDD:290200	6/27 (22%)
		C2H2 Zn finger	1105..1126	CDD:275368	3/24 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144317
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.030