DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9932 and CG8388

DIOPT Version :9

Sequence 1:	NP_609599.1	Gene:	CG9932 / 34701	FlyBaseID:	FBgn0262160	Length:	2171	Species:	Drosophila melanogaster
Sequence 2:	NP_611075.1	Gene:	CG8388 / 36763	FlyBaseID:	FBgn0034062	Length:	572	Species:	Drosophila melanogaster

Alignment Length:	623	Identity:	113/623 - (18%)
Similarity:	197/623 - (31%)	Gaps:	229/623 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 SSLLERHVERFRLQQLLQQQRQAAAVVAVVNSVQQQQQQQPQQVG-MDAKEE--------GLPQC 112
            :|.||.|:        ::.:...:...||     ::::.:|::|. .||:||        .|.:.
  Fly    90 ASALEEHI--------VKSEHDDSVAAAV-----KRRRGRPRKVAQQDAREELKSVLEQINLNEI 141

  Fly   113 KIKRNYSCNHCAYFTQNPRYHLT---HLRDVHGEKIVINKCKLCLYASRH-------FQKLVRHM 167
            ||             :.|...||   .|.|...:..:.:.|     .|:.       .:|....:
  Fly   142 KI-------------EFPEADLTIADVLEDQEEQDFLPDDC-----ISKEGAEDPEVLEKKPPTL 188

  Fly   168 KMVHGCTDGIPSGHGQARGKRGMSREARKRRLEESVGVMGGQSLTVTVPDVPTLEQVKR-----E 227
            |                |...|.||..|:.:|.|.             |:...|.::::     :
  Fly   189 K----------------RKVSGRSRGRRRVQLAER-------------PNTSCLPKIQKSQEFND 224

  Fly   228 LLLQEEKLQRDI-----QAFNQRQREEQQREQQRELELVATSAYERQMQVLRDYERQSPAEPPTP 287
            .:.:..|:|..|     :.|::.....::..:||...:.....:.:: .||.|:.|:.
  Fly   225 YIREHYKVQCHICNLPMEDFSEMLAHVRREHKQRGYAMCCNRKFLKR-GVLVDHLRRH------- 281

  Fly   288 SPTSGSATPPSNGEEPQNRLLKCSACEFTTLYRTQL----RAHELAEHGKTKFFRCDKCSYVTHI 348
                         ::|:.  .|||.|.....:|..|    |.||:...|  :.:||::||...:.
  Fly   282 -------------QDPET--FKCSICGRVMGHRRSLELHMRMHEIKSRG--RLYRCEQCSKAFYS 329

  Fly   349 KARFSKHVKYHSMP----MIKCVTCDFRTPYKWN-----------------------------LD 380
            ...:.:|...| :|    .:.|..|:...|.::.                             |.
  Fly   330 AVVYERHKLTH-IPREQWKVPCTHCEKTYPSQYTMQQHVKLVHLNLYAKICDVCGKSIRGREALA 393

  Fly   381 RHMKNHGGA--GAFKCAACDFTADIKQSLTVHEMNHHVPPVGNAGSIWPRRQNKVGASEMCEDFL 443
            |||:.|.|.  .|.||..||.....|..|.     .|:..:..|.::.|.:         ||..|
  Fly   394 RHMEEHTGGPQAAIKCHLCDSMLTTKYGLA-----RHIKMMHTAENLQPMQ---------CEFCL 444

  Fly   444 SDSAELEDQYNNNNVDDELDGVDDADEAMSGGEEQPLHLHHYGKRSKYDDE-------------- 494
            .....|:                             .|.||.    ||...
  Fly   445 KICPSLQ-----------------------------AHQHHI----KYTHNTARSHQCPMCEKAF 476

  Fly   495 EEPTDLSQKGGCSSDTSSVGTPTPRAQRTMPNLIPISKGAKDV------LNLSKETNASRSSLTE 553
            :.|.:|  |...::.|..|....|...:|..:...:....|.|      .|..|..|.||.|.|.
  Fly   477 KRPNEL--KEHMTTHTGEVLYTCPHCPQTFNSNANMHAHRKKVHRKEWEENRHKRLNRSRKSDTI 539

  Fly   554 IASMFFNEKQISEMLDKSDVPQLSPATTVASQNSTRSQ 591
            ||      ..:.:..:......|.||..:|:.:|.|::
  Fly   540 IA------VSVRKTTETRQDGGLVPAEAIATTSSPRAE 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9932	NP_609599.1	C2H2 Zn finger	339..359	CDD:275368	4/19 (21%)
		C2H2 Zn finger	366..386	CDD:275368	7/48 (15%)
		C2H2 Zn finger	394..414	CDD:275368	5/19 (26%)
		C2H2 Zn finger	816..836	CDD:275370
		C2H2 Zn finger	844..862	CDD:275370
CG8388	NP_611075.1	zf-AD	<21..77	CDD:285071
		C2H2 Zn finger	264..281	CDD:275368	4/17 (24%)
		C2H2 Zn finger	289..309	CDD:275368	6/19 (32%)
		C2H2 Zn finger	320..340	CDD:275368	4/19 (21%)
		C2H2 Zn finger	350..369	CDD:275368	3/18 (17%)
		C2H2 Zn finger	440..461	CDD:275368	9/53 (17%)
		C2H2 Zn finger	469..489	CDD:275368	3/21 (14%)
		C2H2 Zn finger	497..515	CDD:275368	2/17 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444652
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030