DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9932 and kmg

DIOPT Version :9

Sequence 1:	NP_609599.1	Gene:	CG9932 / 34701	FlyBaseID:	FBgn0262160	Length:	2171	Species:	Drosophila melanogaster
Sequence 2:	NP_609604.1	Gene:	kmg / 34706	FlyBaseID:	FBgn0032473	Length:	747	Species:	Drosophila melanogaster

Alignment Length:	1058	Identity:	366/1058 - (34%)
Similarity:	476/1058 - (44%)	Gaps:	342/1058 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDLPSMVQRSGDTLIVRSVVSGNQLYTEQGGHQPTSGNTGHMTSNSTSNTPVAQAGSSLLERHVE 65
            |:|||||:||||.|:|||:|||..||     .....|..|.:...|.|..|:  .|...||:.:|
  Fly     1 MELPSMVERSGDRLVVRSLVSGAPLY-----QSSIEGGAGAVLPMSQSVQPL--IGQDFLEQQLE 58

  Fly    66 RFRLQQLLQQQRQA---AAVVAVVNSVQQQQQQQPQQVG---MDAKEEGLPQCKIKRNYSCNHCA 124
            :::....:.....|   :|..|....:.::..:.....|   .:..::.||||||:||||||.||
  Fly    59 QYKANNFMFPLSMAGFVSADSAPPGDLAKENMENSLPDGNPCNNNNDDELPQCKIRRNYSCNQCA 123

  Fly   125 YFTQNPRYHLTHLRDVHGEKIVINKCKLCLYASRHFQKLVRHMKMVHGCTD--GIPSGHG-QARG 186
            :||||||.||:||||||||:||||:||||||||||||||||||||||||:|  |...|.| |.||
  Fly   124 FFTQNPRSHLSHLRDVHGERIVINECKLCLYASRHFQKLVRHMKMVHGCSDDGGAVQGSGAQPRG 188

  Fly   187 KRGMSREARKRRLEESVGVMG--GQSLTVTV----PDVPTLEQVKRELLLQEEKLQRDIQAFNQR 245
            ||.:|||.||||||||:...|  ||.|.::|    .:.|.|||:|.||..||.:|...:||:|::
  Fly   189 KRNLSREVRKRRLEESIEGQGATGQCLDLSVLRMIQNGPPLEQLKVELQQQEMQLLASVQAYNRQ 253

  Fly   246 QREEQQREQQRELELVATSAYERQMQVL--RDYERQSPAEPPTPSPTSGSATPPSNGEEPQNRLL 308
            |...|.::.....:.:.:.|||.|.:::  :..|.....:..:.|.:..:|..||    |..|
  Fly   254 QEMLQLQQIVESHDNIFSMAYEFQTKLMPPKQAESLKLEQQNSSSDSEETAKSPS----PDTR-- 312

  Fly   309 KCSACEFTTLYRTQLRAHELAEHGKTKFFRCDKCSYVTHIKARFSKHVKYHSMPMIKCVTCDFRT 373
                              ||.. ||.: |:|.||||.|.|:|||.|||||||||:|||.:|||.|
  Fly   313 ------------------ELVS-GKEQ-FQCQKCSYSTPIRARFKKHVKYHSMPLIKCSSCDFHT 357

  Fly   374 PYKWNLDRHMKNHGGAGAFKCAACDFTADIKQSLTVHEMNHHVPPVGNAGSIWPRRQNKVGASEM 438
            |||||||||.||||..|.|||:.|||:.|||||||:||.||||
  Fly   358 PYKWNLDRHTKNHGANGHFKCSCCDFSTDIKQSLTIHESNHHV---------------------- 400

  Fly   439 CEDFLSDSAELEDQYNNNNVDDELDGVDDADEAMSGGEEQPLHLHHYGKRSKYDDEEEPTDLSQK 503
                                                    |:.:|..|.||: |:.|:..|....
  Fly   401 ----------------------------------------PMPVHQMGNRSR-DEAEDLVDQQSS 424

  Fly   504 GGCSSDTSSVGTPTPRAQRTMPNLIPISKGAKDVLNLSKETNASRSSLTEIASMFFNEKQISEML 568
            |....:|...|                  ||
  Fly   425 GSRKPETFKNG------------------GA---------------------------------- 437

  Fly   569 DKSDVPQLSPATTVASQNSTRSQLTKKSSFMDKLKTGAQHENLVCQCGHVAKCLSESIIHGKSCH 633
                        |||   ||.|.|.:.|..:
  Fly   438 ------------TVA---STESLLPRTSGIV---------------------------------- 453

  Fly   634 ASAVIIDEDEAGLHEDDGDDRLEIDEDDEDHHSHSALNLSVTGSTRCQHCRHRCKSSTDLMHHLK 698
                                                          |.||:.|..::..|::||:
  Fly   454 ----------------------------------------------CSHCQKRVGNAMQLINHLQ 472

  Fly   699 QCVEAIRCANEMYDSNSGESGDRRPDSQSLQQQAAVQQQRVCIWNKATKEIIAAAAASLQQDKNN 763
            .|..|:.                    .:.|.||::                     :.:.|.::
  Fly   473 VCTLALH--------------------NTTQLQASI---------------------NAEVDLHD 496

  Fly   764 HNLVKSPTGSQAASNEENSYYGVETAPGYGEVTKKMTPEEEAANSSLKKVYKCPHCSFWASTASR 828
            .:...:||        :.||.|||||||||||| ::.|||....:.||||:|||||||||:||||
  Fly   497 EDFPNAPT--------DLSYCGVETAPGYGEVT-EVLPEEPEDLAPLKKVFKCPHCSFWAATASR 552

  Fly   829 FHVHIVGHLNKKPFECSLCSYRSNWRWDITKHIRLKTIRDPSHKTAKVLMNDETGRRNYTKYNKY 893
            ||||||||||:||||||||:||||||||||||||||.:||.||..|:||||||||||||.|||:|
  Fly   553 FHVHIVGHLNRKPFECSLCAYRSNWRWDITKHIRLKALRDRSHNQAQVLMNDETGRRNYAKYNQY 617

  Fly   894 ITLMKVTEED-GDPKLMKSGEMT-----------PNQVASLAFLKDYAKVGSVSGQDITLEPVLP 946
            :|:|||:.|. .|.|.|::|||.           |.:...:..:.|.|.  |.|..|:
  Fly   618 LTMMKVSAEQLADSKGMRTGEMIVMPPEKLDDHHPMETEEIIEMVDSAH--STSALDL------- 673

  Fly   947 NKPNVLDDAHLADNLIRIPLLATMMNAAMAQQQHQQQQQKEHQSTMITPSVTISPVKRSNQASVM 1011
            .||.......||.|...:|     ...|..:...:....|...|:.:.|....||:..:.    .
  Fly   674 RKPRDDQTEDLAGNSDELP-----QEGAKTEPNLEPLSFKSLNSSQVMPKPKGSPMNLTK----T 729

  Fly  1012 QGKPSDDLITEVHQEGNE 1029
            .|..||:  |....|.||
  Fly   730 DGGQSDE--TTSADESNE 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9932	NP_609599.1	C2H2 Zn finger	339..359	CDD:275368	14/19 (74%)
		C2H2 Zn finger	366..386	CDD:275368	15/19 (79%)
		C2H2 Zn finger	394..414	CDD:275368	13/19 (68%)
		C2H2 Zn finger	816..836	CDD:275370	18/19 (95%)
		C2H2 Zn finger	844..862	CDD:275370	16/17 (94%)
kmg	NP_609604.1	C2H2 Zn finger	540..560	CDD:275370	18/19 (95%)
kmg	NP_609604.1	C2H2 Zn finger	568..586	CDD:275370	16/17 (94%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442599
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BC9A
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1903at7147
OrthoFinder	1	1.000	-	-		FOG0009969
OrthoInspector	1	1.000	-	-		otm40680
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24403
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.850