DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9932 and Zfp64

DIOPT Version :9

Sequence 1:	NP_609599.1	Gene:	CG9932 / 34701	FlyBaseID:	FBgn0262160	Length:	2171	Species:	Drosophila melanogaster
Sequence 2:	NP_001012093.1	Gene:	Zfp64 / 311661	RGDID:	1307948	Length:	678	Species:	Rattus norvegicus

Alignment Length:	721	Identity:	116/721 - (16%)
Similarity:	210/721 - (29%)	Gaps:	273/721 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly  1412 PGSPSLLTMADGDRREPSPYRCGHC-HQVSNWKHVI---QRHCRLKHSGDIRIETLERGASVSAN 1472
            ||..::|.     ...|..:.||.| .|.||....:   |..|:|..:
  Rat    17 PGGTTVLV-----ELTPDIHICGLCKQQFSNLDAFVAHKQSGCQLTTT----------------- 59

  Fly  1473 APPIYRPLGAGASNESQSHIHNPSNPITSNILKSGSNTN-----ANSNINSNSAQPLLLTTKQLE 1532
                  |:.|.::.:..|....|:.|..:......|.|.     |...:..:..|..|.|....:
  Rat    60 ------PVTAPSTVQFVSEETVPATPTQTATTTISSETQTITVAAPEFVFEHGYQTYLPTESTDD 118

  Fly  1533 QIFHTPLSASAAAVVNAANTQQDIQAAAAYWAAACKAVVANSSAEELLQLQQNDQIEITRLPTTT 1597
            |      :|:..|:.....|::.....|......|.......:|..:..::::.:|
  Rat   119 Q------TATVIALPTKTRTKKPTAPPAQKKLGCCYPGCQFKTAYGMKDMERHLKI--------- 168

  Fly  1598 EHSIGSSGNNTKSKQQKCPVCPYISESKSQMNYHVSLH---KPTQYECRLCTFVCAKKQHLSSHM 1659
                     :|..|..||.||......|.::..|:..|   ||  |:|:.|.:..|....|:.|:
  Rat   169 ---------HTGDKPHKCEVCGKCFSRKDKLKTHMRCHTGVKP--YKCKTCDYAAADSSSLNKHL 222

  Fly  1660 RTVHQQQMVASGAGAAAGAAGGVGGGGAASLGLDFSVALQLAAAAKQVQQLPASTPLSIDLSQIQ 1724
            | :|..:.                           ....|:...|.:     .|:.|::.|....
  Rat   223 R-IHSDER---------------------------PFKCQICPYASR-----NSSQLTVHLRSHT 254

  Fly  1725 MDAASDAELNPQQLPPEYQYKLISYCPRCPARFAQKHNDERNAKQELEQHLLAHSDQEP------ 1783
            .||       |.|            |..|.|:|        ....:|::|:..||.::|
  Rat   255 GDA-------PFQ------------CWLCSAKF--------KISSDLKRHMRVHSGEKPFKCDFC 292

  Fly  1784 ----------------EDQDPSYVCAYCEYRTSEETMLQLHRAVHMSHYQEKCQELYRNCKEDVE 1832
                            :....::.|.:|::....::.|:.|..:|.|.:.|||.|...:|.....
  Rat   293 NVRCTMKGNLKSHIRIKHSGNNFKCPHCDFLGDSKSTLRKHSRLHQSEHPEKCAECSYSCSSKAA 357

  Fly  1833 YPAPKLLQLTGPETIWVVDNELSLQLLQQTTGGAVSTSTGGFDNQNSLLKKQLESGGGQMVPLPL 1897
            ....:.:..|
  Rat   358 LRVHERIHCT------------------------------------------------------- 367

  Fly  1898 KVSVNKNEAEVPEEDEERHSSSTPSTSASVATSDLAADGSSDAGSVDMPQSIPAPERCLHCPFET 1962
                            ||                                    |.:|.:|.|:|
  Rat   368 ----------------ER------------------------------------PFKCSYCSFDT 380

  Fly  1963 QQHEELMQHLQKHACVNPPPPNCQKCAHCDYNANEEAEMEEHTALHFNAGEKLKSVEFFTCYDQL 2027
            :|...|.:|::|.              |.|...||..|.::..........||.:.:.|.| |..
  Rat   381 KQPSNLSKHMKKF--------------HADTLKNEAPERKDSGRQSSRQVAKLDAKKTFHC-DIC 430

  Fly  2028 EISVEREPEETADSKVEQTEHNNNQDNVMNANVQQQQQQQPSSSGPDE--QPAVEGMEESSAKKS 2090
            :.|..|| :.....|.:.:|:::...:|....:..:..:||::....|  |..::..:.|...:.
  Rat   431 DASFMRE-DSLRSHKRQHSEYHSKNSDVTVVQLHLEPSKQPAAPLTVEHLQVPLQSSQVSQFNEG 494

  Fly  2091 STKLIL 2096
            |.|:|:
  Rat   495 SVKIIV 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9932	NP_609599.1	C2H2 Zn finger	339..359	CDD:275368
		C2H2 Zn finger	366..386	CDD:275368
		C2H2 Zn finger	394..414	CDD:275368
		C2H2 Zn finger	816..836	CDD:275370
		C2H2 Zn finger	844..862	CDD:275370
Zfp64	NP_001012093.1	COG5048	<151..450	CDD:227381	76/501 (15%)
		zf-H2C2_2	161..186	CDD:290200	7/42 (17%)
		C2H2 Zn finger	177..197	CDD:275368	5/19 (26%)
		zf-H2C2_2	190..211	CDD:290200	7/22 (32%)
		C2H2 Zn finger	205..225	CDD:275368	6/20 (30%)
		zf-H2C2_2	217..239	CDD:290200	5/49 (10%)
		C2H2 Zn finger	233..253	CDD:275368	5/24 (21%)
		C2H2 Zn finger	261..281	CDD:275368	6/27 (22%)
		zf-H2C2_2	273..297	CDD:290200	5/23 (22%)
		C2H2 Zn finger	289..308	CDD:275368	0/18 (0%)
		C2H2 Zn finger	345..365	CDD:275368	3/19 (16%)
		zf-H2C2_2	357..382	CDD:290200	8/131 (6%)
		C2H2 Zn finger	373..391	CDD:275368	7/17 (41%)
		zf-C2H2_6	424..450	CDD:290623	7/27 (26%)
		C2H2 Zn finger	427..447	CDD:275368	6/21 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338044
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030