DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9932 and Zfp64

DIOPT Version :9

Sequence 1:	NP_609599.1	Gene:	CG9932 / 34701	FlyBaseID:	FBgn0262160	Length:	2171	Species:	Drosophila melanogaster
Sequence 2:	NP_033590.2	Gene:	Zfp64 / 22722	MGIID:	107342	Length:	676	Species:	Mus musculus

Alignment Length:	1193	Identity:	185/1193 - (15%)
Similarity:	299/1193 - (25%)	Gaps:	611/1193 - (51%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 INKCKLCLYASRHFQKL---VRHMKMVHGCTDGIPSGHGQARGKRGMSREARKRRLEESVGVMGG 208
            |:.|.||   .:||..|   |.|.:  .||
Mouse    30 IHICGLC---KQHFSNLDAFVAHKQ--SGC----------------------------------- 54

  Fly   209 QSLTVTVPDVP-TLEQVKRELLLQEEKLQRDIQAFNQRQREEQQREQQRELELVATSAYERQMQV 272
             .||.|....| |::.|..|   .|...|......:.            |.:.:..||.|...:
Mouse    55 -QLTTTPVTAPSTVQFVAEE---TEPATQTTTTTISS------------ETQTITVSAPEFVFE- 102

  Fly   273 LRDYERQSPAEP-----------PTPSPTSGSATPPSNGEEPQNRLLKC-SACEFTTLYRTQLRA 325
             ..|:...|.|.           ||.|.|.....||:     |.||..| ..|:|.|.|..:...
Mouse   103 -HGYQTYLPTESTDNQTATVISLPTKSRTKKPTAPPA-----QKRLGCCYPGCQFKTAYGMKDME 161

  Fly   326 HELAEHGKTKFFRCDKCSYVTHIKARFSKHVKYHS-MPMIKCVTCDFRTPYKWNLDRHMKNHGGA 389
            ..|..|...|..:|:.|......|.:...|::.|: :...||.|||:......:|::|::.|...
Mouse   162 RHLKIHTGDKPHKCEVCGKCFSRKDKLKTHMRCHTGVKPYKCKTCDYAAADSSSLNKHLRIHSDE 226

  Fly   390 GAFKCAACDFTADIKQSLTVHEMNHHVPPVGNAG-SIWPRRQNKVGASEMCEDFLSDSAELEDQY 453
            ..|||..|.:.:.....||||..:|    .|:|. ..|           :|......|::|:
Mouse   227 RPFKCQICPYASRNSSQLTVHLRSH----TGDAPFQCW-----------LCSAKFKISSDLK--- 273

  Fly   454 NNNNVDDELDGVDDADEAMSGGEEQPLHLH-HYGKRSKYDDEEEPTDLSQKGGCSSDTSSVGTPT 517
                                      .|:. |.|        |:|
Mouse   274 --------------------------RHMRVHSG--------EKP-------------------- 284

  Fly   518 PRAQRTMPNLIPISKGAKDVLNLSKETNASRSSLTEIASMFFNEKQISEMLDKSDVPQLSPATTV 582

Mouse   285 ----------------------------------------------------------------- 284

  Fly   583 ASQNSTRSQLTKKSSFMDKLKTGAQHENLVCQCGHVAKCLSESIIHGKSCHASAVIIDEDEAGLH 647

Mouse   285 ----------------------------------------------------------------- 284

  Fly   648 EDDGDDRLEIDEDDEDHHSHSALNLSVTGSTRCQHCRHRCKSSTDLMHH--LKQCVEAIRC--AN 708
                                          .:|:.|..||....:|..|  :|......:|  .:
Mouse   285 ------------------------------FKCEFCNVRCTMKGNLKSHIRIKHSGNNFKCPHCD 319

  Fly   709 EMYDSNSGESGDRRPDSQSLQQQAAVQQQRVCIWNKATKEIIAAAAASLQQDKNNHNLVKSPTGS 773
            .:.||.|           :|::.:.:.|                         :.|
Mouse   320 FLGDSKS-----------TLRKHSRLHQ-------------------------SEH--------- 339

  Fly   774 QAASNEENSYYGVETAPGYGEVTKKMTPEEEAANSSLKKVYKCPHCSFWASTASRFHVHIVGHLN 838
                                       ||            |||.||:..|:.:...||...|..
Mouse   340 ---------------------------PE------------KCPECSYSCSSKAALRVHERIHCT 365

  Fly   839 KKPFECSLCSYRSNWRWDITKHIRLKTIRDPSHKTAKVLMNDETGRRNYTKYNKYITLMKVTEED 903
            ::||:||.||:.:....:::||::      ..|  |.:|.|:.
Mouse   366 ERPFKCSYCSFDTKQPSNLSKHMK------KFH--ADMLKNEA---------------------- 400

  Fly   904 GDPKLMKSGEMTPNQVASLAFLKDYAKVGSVSGQDITLEPVLPNKPNVLDDAHLADNLIRIPLLA 968
              |:..:||..:..|||.|...|.:                   ..::.|.:.:.::.:|
Mouse   401 --PEKKESGRQSSRQVARLDAKKTF-------------------HCDICDASFMREDSLR----- 439

  Fly   969 TMMNAAMAQQQHQQQQQKEHQSTMITPSVTISPVKRSNQASVMQGKPSDDLITEVHQEGNEKRTV 1033
                      .|::|..:.|                        .|.||..:.::|.|.:::...
Mouse   440 ----------SHKRQHSEYH------------------------SKNSDVTVVQLHLEPSKQPAA 470

  Fly  1034 YRCRKCNFGHQNRDAVLAHVKIHYQDASYPKSNSGNSSTSPLQVSVGGS-PQFYMNKVFAAMC-- 1095
                         ...:..:::..|.:..|:.:.|.     :::.||.. ||  .|.:..|..
Mouse   471 -------------PLTVEQIQVPLQSSQVPQFSEGR-----VKIIVGHQVPQ--TNAIVQAAAAA 515

  Fly  1096 --------LSQTQSQSSPNSGSAGTSPAISAGLLQRAIQEAQHSPTPNASALSGLALALAGGKPQ 1152
                    ::||..:...|            |.||...|.:..:| |.:|...|
Mouse   516 VNIVPPTLVAQTPEEIPGN------------GRLQILRQVSLIAP-PQSSGCPG----------- 556

  Fly  1153 ANTTKASAASILEHGEQKASQNEASADSLTSPNTTTTNSTTSRTTKDTTA-RSLQDLL--TSPRS 1214
                                    .|.:|:.|       |...||.|.|| .:||..|  |:|..
Mouse   557 ------------------------EAGALSQP-------TVLLTTHDQTAGAALQQALIPTTPVG 590

  Fly  1215 ARNGNHPSNANSNSVVGNGLR------LDAVYVASSTNNTTTPPPPPTNSVSKPNASPLPVTTTP 1273
            .:.|    ..|...:..:|:.      |:|:....:|..|.         ||..:.|....||.|
Mouse   591 TQEG----TGNQTFIASSGITCSDLEGLNALIQEGTTEVTV---------VSDGDQSIAVATTAP 642

  Fly  1274 TPISTATPL-----------AHP 1285
            :..||...|           |||
Mouse   643 SIFSTQQELPKQTYSIIHGAAHP 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9932	NP_609599.1	C2H2 Zn finger	339..359	CDD:275368	4/19 (21%)
		C2H2 Zn finger	366..386	CDD:275368	6/19 (32%)
		C2H2 Zn finger	394..414	CDD:275368	6/19 (32%)
		C2H2 Zn finger	816..836	CDD:275370	7/19 (37%)
		C2H2 Zn finger	844..862	CDD:275370	6/17 (35%)
Zfp64	NP_033590.2	COG5048	<149..448	CDD:227381	89/680 (13%)
		zf-H2C2_2	159..184	CDD:290200	5/24 (21%)
		C2H2 Zn finger	175..195	CDD:275368	4/19 (21%)
		zf-H2C2_2	188..209	CDD:290200	7/20 (35%)
		C2H2 Zn finger	203..223	CDD:275368	6/19 (32%)
		zf-H2C2_2	215..237	CDD:290200	7/21 (33%)
		C2H2 Zn finger	231..251	CDD:275368	6/19 (32%)
		C2H2 Zn finger	259..279	CDD:275368	5/59 (8%)
		zf-H2C2_2	271..295	CDD:290200	9/240 (4%)
		C2H2 Zn finger	287..306	CDD:275368	6/18 (33%)
		C2H2 Zn finger	343..363	CDD:275368	7/19 (37%)
		zf-H2C2_2	355..380	CDD:290200	9/24 (38%)
		C2H2 Zn finger	371..389	CDD:275368	6/17 (35%)
		zf-C2H2_6	422..448	CDD:290623	4/59 (7%)
		C2H2 Zn finger	425..445	CDD:275368	3/34 (9%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834468
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030